Abstract
Carbachol and magnesium sulphate were used to increase the motility of the intestine in healthy volunteers. The effect was estimated by recording changes in abdominal sounds. Serum 5-hydroxytryptamine levels were assayed and found to be higher after gastrointestinal stimulation.
Full text
PDF





Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLEEHEN N. M. Precipitation by fatty food of systemic disturbance from argentaffinoma. Lancet. 1955 Dec 31;269(6905):1362–1363. doi: 10.1016/s0140-6736(55)93162-7. [DOI] [PubMed] [Google Scholar]
- BULBRING E., CREMA A. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br J Pharmacol Chemother. 1958 Dec;13(4):444–457. doi: 10.1111/j.1476-5381.1958.tb00236.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CODE C. F., HIGHTOWER N. C., Jr, MORLOCK C. G. Motility of the alimentary canal in man; review of recent studies. Am J Med. 1952 Sep;13(3):328–351. doi: 10.1016/0002-9343(52)90287-8. [DOI] [PubMed] [Google Scholar]
- CONNELL A. M., ROWLANDS E. N., WILCOX P. B. Serotonin, bananas, and diarrhoea. Gut. 1960 Mar;1:44–47. doi: 10.1136/gut.1.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAUGHERTY G. W., MANGER W. M., ROTH G. M., FLOCK E. V., CHILDS D. S., Jr, WAUGH J. M. Malignant carcinoid with hyperserotonemia occurring spontaneously or induced by palpation of the tumor or by intravenous histamine: report of a case. Proc Staff Meet Mayo Clin. 1955 Dec 14;30(25):595–601. [PubMed] [Google Scholar]
- DU PLESSIS D. J. Clinical observations on intestinal motility. S Afr Med J. 1954 Jan 9;28(2):27–33. [PubMed] [Google Scholar]
- ERSPAMER V., TESTINI A. Observations on the release and turnover rate of 5-hydroxytryptamine in the gastrointestinal tract. J Pharm Pharmacol. 1959 Oct;11:618–623. doi: 10.1111/j.2042-7158.1959.tb12603.x. [DOI] [PubMed] [Google Scholar]
- Epps H. M. The development of amine oxidase activity by human tissues after birth. Biochem J. 1945;39(1):37–42. doi: 10.1042/bj0390037. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FARRAR J. T., INGELFINGER F. J. Gastrointestinal motility as revealed by study of abdominal sounds. Gastroenterology. 1955 Nov;29(5):789–802. [PubMed] [Google Scholar]
- FELDBERG W., TOH C. C. Distribution of 5-hydroxytryptamine (serotonin, enteramine) in the wall of the digestive tract. J Physiol. 1953 Feb 27;119(2-3):352–362. doi: 10.1113/jphysiol.1953.sp004850. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARDISTY R. M., STACEY R. S. 5-Hydroxytryptamine in normal human platelets. J Physiol. 1955 Dec 29;130(3):711–720. doi: 10.1113/jphysiol.1955.sp005437. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAVERBACK B. J., DAVIDSON J. D. Serotonin and the gastrointestinal tract. Gastroenterology. 1958 Dec;35(6):570–578. [PubMed] [Google Scholar]
- HAVERBACK B. J., HOGBEN C. A., MORAN N. C., TERRY L. L. Effect of serotonin (5-hydroxytryptamine) and related compounds on gastric secretion and intestinal motility in the dog. Gastroenterology. 1957 Jun;32(6):1058–1065. [PubMed] [Google Scholar]
- HENDRIX T. R., ATKINSON M., CLIFTON J. A., INGELFINGER F. J. The effect of 5-hydroxytryptamine on intestinal motor function in man. Am J Med. 1957 Dec;23(6):886–893. doi: 10.1016/0002-9343(57)90298-x. [DOI] [PubMed] [Google Scholar]
- HOLZBAUER M., VOGT M. The concentration of adrenaline in the peripheral blood during insulin hypoglycaemia. Br J Pharmacol Chemother. 1954 Jun;9(2):249–252. doi: 10.1111/j.1476-5381.1954.tb00849.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUGH-JONES P., LAMBERT A. V. A simple standard exercise test and its use for measuring exertion dyspnoea. Br Med J. 1952 Jan 12;1(4749):65–71. doi: 10.1136/bmj.1.4749.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KOWLESSAR O. D., WILLIAMS R. C., LAW D. H., SLEISENGER M. H. Urinary excretion of 5-hydroxyindolacetic acid in diarrheal states, with special reference to nontropical sprue. N Engl J Med. 1958 Aug 14;259(7):340–341. doi: 10.1056/NEJM195808142590708. [DOI] [PubMed] [Google Scholar]
- MILTON G. W. Normal bowel sounds. Med J Aust. 1958 Oct 11;45(15):490–493. doi: 10.5694/j.1326-5377.1958.tb67121.x. [DOI] [PubMed] [Google Scholar]
- PARE C. M., SANDLER M., STACEY R. S. 5-Hydroxytryptamine deficiency in phenylketonuria. Lancet. 1957 Mar 16;272(6968):551–553. doi: 10.1016/s0140-6736(57)90920-0. [DOI] [PubMed] [Google Scholar]
- SHARMAN D. F., SULLIVAN F. M. 5-Hydroxytryptamine in serum. Nature. 1956 Feb 18;177(4503):332–333. doi: 10.1038/177332b0. [DOI] [PubMed] [Google Scholar]
- SNOW P. J., LENNARD-JONES J. E., CURZON G., STACEY R. S. Humoral effects of metastasising carcinoid tumours. Lancet. 1955 Nov 12;269(6898):1004–1009. doi: 10.1016/s0140-6736(55)93431-0. [DOI] [PubMed] [Google Scholar]
- THORSON A. H. Hemodynamic changes during flush in carcinoidosis; the carcinoid syndrome. Am Heart J. 1956 Sep;52(3):444–461. doi: 10.1016/0002-8703(56)90218-6. [DOI] [PubMed] [Google Scholar]
- TOH C. C. Release of 5-hydroxytryptamine (serotonin) from the dog's gastrointestinal tract. J Physiol. 1954 Nov 29;126(2):248–254. doi: 10.1113/jphysiol.1954.sp005206. [DOI] [PMC free article] [PubMed] [Google Scholar]
- UDENFRIEND S., WEISSBACH H. Turnover of 5-hydroxytryptamine (serotonin) in tissues. Proc Soc Exp Biol Med. 1958 Apr;97(4):748–751. doi: 10.3181/00379727-97-23868. [DOI] [PubMed] [Google Scholar]
- VAUGHAN WILLIAMS E. M. The mode of action of drugs upon intestinal motility. Pharmacol Rev. 1954 Jun;6(2):159–190. [PubMed] [Google Scholar]
- WALDENSTROM J., LJUNGBERG E. Studies on the functional circulatory influence from metastasizing carcinoid (argentaffine, enterochromaffine) tumours and their possible relation to enteramine production. I. Symptoms of cardinoidosis. Acta Med Scand. 1955 Nov 10;152(4):293–309. doi: 10.1111/j.0954-6820.1955.tb03490.x. [DOI] [PubMed] [Google Scholar]
- ZUCKER M. B., BORRELLI J. Quantity, assay and release of serotonin in human platelets. J Appl Physiol. 1955 Jan;7(4):425–431. doi: 10.1152/jappl.1955.7.4.425. [DOI] [PubMed] [Google Scholar]

