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. 1985 Jun 1;290(6482):1633–1636. doi: 10.1136/bmj.290.6482.1633

Drugs prescribed for self poisoners.

L F Prescott, M S Highley
PMCID: PMC1415810  PMID: 3924200

Abstract

Of 230 adults admitted for self poisoning over two months, 153 (67%) had previously been taking a total of 309 prescribed drugs. Of these patients, 119 (78%) had been given psychotropic drugs (usually benzodiazepines), 81 (53%) obtained them on repeat prescription, and 47 (31%) had been prescribed multiple psychotropic drugs, often in seemingly illogical combinations. The use of these drugs increased progressively with age and most patients took the same drugs in overdosage as they had been prescribed. Psychotropic drugs were prescribed for more than a third of patients with no psychiatric illness and a normal personality, nearly half of those with existing alcohol or drug abuse problems, and for most of the unemployed. Fewer than a third of the patients suffering from depression were prescribed antidepressants but half had been given benzodiazepines and other potentially depressing drugs. Psychotropic drug use, psychotropic polypharmacy, and the repeat prescribing of these drugs were strongly associated with repeated overdosage and, under certain circumstances, with personality disorder, alcohol or drug abuse, unemployment, and conflict with the law. In the long term psychotropic drugs are unlikely to benefit most self poisoners, and they may do positive harm by inducing apathy and depression and predisposing to self poisoning. The incidence of self poisoning (and repeat overdosage in particular) might be reduced by more care and restraint in the prescribing of these drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ananth J., Ghadirian A. M. Drug-induced mood disorders. Int Pharmacopsychiatry. 1980;15(1):59–73. doi: 10.1159/000468412. [DOI] [PubMed] [Google Scholar]
  2. Ashton H. Benzodiazepine withdrawal: an unfinished story. Br Med J (Clin Res Ed) 1984 Apr 14;288(6424):1135–1140. doi: 10.1136/bmj.288.6424.1135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baker P. M., Bartholomeusz D. B., Siskind M., Whitlock F. A. Drug-induced depression and attempted suicide. Med J Aust. 1977 Sep 3;2(10):322–324. doi: 10.5694/j.1326-5377.1977.tb99165.x. [DOI] [PubMed] [Google Scholar]
  4. Brewer C., Farmer R. Self poisoning in 1984: a prediction that didn't come true. Br Med J (Clin Res Ed) 1985 Feb 2;290(6465):391–391. doi: 10.1136/bmj.290.6465.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ghodse A. H. Deliberate self-poisoning: a study in London casualty departments. Br Med J. 1977 Mar 26;1(6064):805–808. doi: 10.1136/bmj.1.6064.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hall R. C., Joffe J. R. Aberrant response to diazepam: a new syndrome. Am J Psychiatry. 1972 Dec;129(6):738–742. doi: 10.1176/ajp.129.6.738. [DOI] [PubMed] [Google Scholar]
  7. Hawton K., Blackstock E. Deliberate self-poisoning: implications for psychotropic drug prescribing in general practice. J R Coll Gen Pract. 1977 Sep;27(182):560–563. [PMC free article] [PubMed] [Google Scholar]
  8. Hopkins D. R., Sethi K. B., Mucklow J. C. Benzodiazepine withdrawal in general practice. J R Coll Gen Pract. 1982 Dec;32(245):758–762. [PMC free article] [PubMed] [Google Scholar]
  9. Jacobsen D., Frederichsen P. S., Knutsen K. M., Sørum Y., Talseth T., Odegaard O. R. A prospective study of 1212 cases of acute poisoning: general epidemiology. Hum Toxicol. 1984 Apr;3(2):93–106. doi: 10.1177/096032718400300203. [DOI] [PubMed] [Google Scholar]
  10. Johnson D. A. Drug-induced psychiatric disorders. Drugs. 1981 Jul;22(1):57–69. doi: 10.2165/00003495-198122010-00004. [DOI] [PubMed] [Google Scholar]
  11. Jones D. R. A follow-up of self-poisoned patients. J R Coll Gen Pract. 1977 Dec;27(185):717–719. [PMC free article] [PubMed] [Google Scholar]
  12. Kessel N. The respectability of self-poisoning and the fashion of survival. J Psychosom Res. 1966 Jul;10(1):29–36. doi: 10.1016/0022-3999(66)90132-2. [DOI] [PubMed] [Google Scholar]
  13. Khan A., Hornblow A. R., Walshe J. W. Benzodiazepine dependence: a general practice survey. N Z Med J. 1981 Jul 8;93(687):19–21. [PubMed] [Google Scholar]
  14. Oswald I. The why and how of hypnotic drugs. Br Med J. 1979 May 5;1(6172):1167–1168. doi: 10.1136/bmj.1.6172.1167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Owen R. T., Tyrer P. Benzodiazepine dependence. A review of the evidence. Drugs. 1983 Apr;25(4):385–398. doi: 10.2165/00003495-198325040-00003. [DOI] [PubMed] [Google Scholar]
  16. Petursson H., Lader M. H. Withdrawal from long-term benzodiazepine treatment. Br Med J (Clin Res Ed) 1981 Sep 5;283(6292):643–645. doi: 10.1136/bmj.283.6292.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Proudfoot A. T., Park J. Changing pattern of drugs used for self-poisoning. Br Med J. 1978 Jan 14;1(6105):90–93. doi: 10.1136/bmj.1.6105.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Skegg K., Skegg D. C., Richards S. M. Incidence of self poisoning in patients prescribed psychotropic drugs. Br Med J (Clin Res Ed) 1983 Mar 12;286(6368):841–843. doi: 10.1136/bmj.286.6368.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Starkey I. R., Lawson A. A. Psychiatric aspects of acute poisoning with tricyclic and related antidepressants--a ten-year review. Scott Med J. 1980 Oct;25(4):303–308. doi: 10.1177/003693308002500412. [DOI] [PubMed] [Google Scholar]

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