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. 1985 Aug 3;291(6491):299–302. doi: 10.1136/bmj.291.6491.299

Experimental transmission of an autosomal dominant spongiform encephalopathy: does the infectious agent originate in the human genome?

H F Baker, R M Ridley, T J Crow
PMCID: PMC1416561  PMID: 3926166

Abstract

Marmosets inoculated intracerebrally with brain tissue from a woman with Gerstmann-Straussler syndrome (an autosomal dominant dementia associated with spongiform change and amyloid deposition) developed an encephalopathy indistinguishable from that seen in marmosets inoculated with brain tissue from a typical case of Creutzfeldt-Jakob disease. As in Huntington's disease, in the pedigree of the patient with Gerstmann-Straussler syndrome women who subsequently developed the illness had increased fecundity. The pathogen in human transmissible dementia may arise from a sequence (which itself sometimes confers a selective advantage) located within the human genome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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