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. 1985 Feb 9;290(6466):422–424. doi: 10.1136/bmj.290.6466.422

Are low cholesterol values associated with excess mortality?

C E Salmond, R Beaglehole, I A Prior
PMCID: PMC1417777  PMID: 3918613

Abstract

The relation between cholesterol concentration and mortality was studied prospectively over 17 years in 630 New Zealand Maoris aged 25-74. The dead or alive state of each person was determined in 1981. The causes of death were divided into three categories: cancer, cardiovascular disease, and "other." Using univariate and both linear and non-linear multivariate methods of analysis for survivorship data, significant inverse relations with serum cholesterol were found for total mortality in women, for mortality from cancer in men and women, and for other causes of mortality in both men and women. The inverse and non-linear association with total mortality in women remained significant when deaths in the first five years of follow up were excluded. This suggests that the association was not explained by undetected illness causing low cholesterol concentrations at the time of initial examination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaglehole R., Foulkes M. A., Prior I. A., Eyles E. F. Cholesterol and mortality in New Zealand Maoris. Br Med J. 1980 Feb 2;280(6210):285–287. doi: 10.1136/bmj.280.6210.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cambien F., Ducimetiere P., Richard J. Total serum cholesterol and cancer mortality in a middle-aged male population. Am J Epidemiol. 1980 Sep;112(3):388–394. doi: 10.1093/oxfordjournals.aje.a113004. [DOI] [PubMed] [Google Scholar]
  3. Feinleib M. Summary of a workshop on cholesterol and noncardiovascular disease mortality. Prev Med. 1982 May;11(3):360–367. doi: 10.1016/0091-7435(82)90059-7. [DOI] [PubMed] [Google Scholar]
  4. Garcia-Palmieri M. R., Sorlie P. D., Costas R., Jr, Havlik R. J. An apparent inverse relationship between serum cholesterol and cancer mortality in Puerto Rico. Am J Epidemiol. 1981 Jul;114(1):29–40. doi: 10.1093/oxfordjournals.aje.a113171. [DOI] [PubMed] [Google Scholar]
  5. Kagan A., McGee D. L., Yano K., Rhoads G. G., Nomura A. Serum cholesterol and mortality in a Japanese-American population: the Honolulu Heart program. Am J Epidemiol. 1981 Jul;114(1):11–20. doi: 10.1093/oxfordjournals.aje.a113157. [DOI] [PubMed] [Google Scholar]
  6. Kark J. D., Smith A. H., Hames C. G. Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J (Clin Res Ed) 1982 Jan 16;284(6310):152–154. doi: 10.1136/bmj.284.6310.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1966 Mar;50(3):163–170. [PubMed] [Google Scholar]
  8. Marenah C. B., Lewis B., Hassall D., La Ville A., Cortese C., Mitchell W. D., Bruckdorfer K. R., Slavin B., Miller N. E., Turner P. R. Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations. Br Med J (Clin Res Ed) 1983 May 21;286(6378):1603–1606. doi: 10.1136/bmj.286.6378.1603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Morris D. L., Borhani N. O., Fitzsimons E., Hardy R. J., Hawkins C. M., Kraus J. F., Labarthe D. R., Mastbaum L., Payne G. H. Serum cholesterol and cancer in the Hypertension Detection and Follow-up Program. Cancer. 1983 Nov 1;52(9):1754–1759. doi: 10.1002/1097-0142(19831101)52:9<1754::aid-cncr2820520933>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  10. Peterson B., Trell E., Sternby N. H. Low cholesterol level as risk factor for noncoronary death in middle-aged men. JAMA. 1981 May 22;245(20):2056–2057. [PubMed] [Google Scholar]
  11. Prior I. A. Cardiovascular epidemiology in New Zealand and the Pacific. N Z Med J. 1974 Sep 25;80(524):245–252. [PubMed] [Google Scholar]
  12. Rose G., Shipley M. J. Plasma lipids and mortality: a source of error. Lancet. 1980 Mar 8;1(8167):523–526. doi: 10.1016/s0140-6736(80)92775-0. [DOI] [PubMed] [Google Scholar]
  13. Sorlie P. D., Feinleib M. The serum cholesterol-cancer relationship: an analysis of time trends in the Framingham Study. J Natl Cancer Inst. 1982 Nov;69(5):989–996. [PubMed] [Google Scholar]
  14. Stemmermann G. N., Nomura A. M., Heilbrun L. K., Pollack E. S., Kagan A. Serum cholesterol and colon cancer incidence in Hawaiian Japanese men. J Natl Cancer Inst. 1981 Dec;67(6):1179–1182. [PubMed] [Google Scholar]

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