Abstract
Dermal nitrate preparations are claimed to be useful in the treatment of angina, as their slow absorption by-passing the liver leads to a sustained action. Ten patients with angina were exercised on a treadmill after dermal application of 16.64 mg glyceryl trinitrate or 100 mg isosorbide dinitrate or placebo. Exercise duration was significantly increased at one and three hours for both nitrate preparations but not at six hours after application. The calculated workload achieved was significantly increased (p less than 0.01) at one and three hours for both preparations and at six hours (p less than 0.05) for isosorbide dinitrate. Headaches were common with glyceryl trinitrate cream. The dermal nitrate preparations studied had a duration of antianginal action similar to that of oral nitrate tablets. Aside from their value when the oral route cannot be used or absorption may be delayed, dermal nitrate preparations have no advantage over oral preparations for angina pectoris.
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Selected References
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- Cheadle B., Cooke J., Morrison G. W. Transdermal drug administration--a nuisance becomes an opportunity. Br Med J (Clin Res Ed) 1981 Dec 5;283(6305):1549–1549. doi: 10.1136/bmj.283.6305.1549-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davidov M. E. Cutaneous administration of nitroglycerin in patients with angina pectoris. Angiology. 1981 Jan;32(1):16–20. doi: 10.1177/000331978103200102. [DOI] [PubMed] [Google Scholar]
- Needleman P., Lang S., Johnson E. M., Jr Organic nitrates: relationship between biotransformation and rational angina pectoris therapy. J Pharmacol Exp Ther. 1972 Jun;181(3):489–497. [PubMed] [Google Scholar]
- Reichek N., Goldstein R. E., Redwood D. R., Epstein S. E. Sustained effects of nitroglycerin ointment in patients with angina pectoris. Circulation. 1974 Aug;50(2):348–352. doi: 10.1161/01.cir.50.2.348. [DOI] [PubMed] [Google Scholar]
- Thadani U., Fung H. L., Darke A. C., Parker J. O. Oral isosorbide dinitrate in the treatment of angina pectoris. Dose-response relationship and duration of action during acute therapy. Circulation. 1980 Sep;62(3):491–502. doi: 10.1161/01.cir.62.3.491. [DOI] [PubMed] [Google Scholar]