Skip to main content
NCBI home page
Gut logoLink to Gut
. 1979 Jan;20(1):75–87. doi: 10.1136/gut.20.1.75

Gastrointestinal cytoprotection by prostaglandins.

T A Miller, E D Jacobson
PMCID: PMC1418958  PMID: 367886

Full text

PDF
75

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aso K., Deneau D. G., Krulig L., Wilkinson D. I., Farber E. M. Epidermal synthesis of prostaglandins and their effect on levels of cyclic adenosine 3', 5'monophosphate. J Invest Dermatol. 1975 May;64(5):326–331. doi: 10.1111/1523-1747.ep12512267. [DOI] [PubMed] [Google Scholar]
  2. Aso K., Orenberg E. K., Farber E. M. Reduced epidermal cyclic AMP accumulation following prostaglandin stimulation: Its possible role in the pathophysiology of psoriasis. J Invest Dermatol. 1975 Oct;65(4):375–378. doi: 10.1111/1523-1747.ep12607628. [DOI] [PubMed] [Google Scholar]
  3. Augur N. A., Jr Gastric mucosal blood flow following damage by ethanol, acetic acid, or aspirin. Gastroenterology. 1970 Mar;58(3):311–320. [PubMed] [Google Scholar]
  4. Bennett A., Curwain B. P. Effects of aspirin-like drugs on canine gastric mucosal blood flow and acid secretion. Br J Pharmacol. 1977 Aug;60(4):499–504. doi: 10.1111/j.1476-5381.1977.tb07527.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bennett A., Friedmann C. A., Vane J. R. Release of prostaglandin E-1 from the rat stomach. Nature. 1967 Dec 2;216(5118):873–876. doi: 10.1038/216873a0. [DOI] [PubMed] [Google Scholar]
  6. Bennett A., Murray J. G., Wyllie J. H. Occurrence of prostaglandin E2 in the human stomach, and a study of its effects on human isolated gastric muscle. Br J Pharmacol Chemother. 1968;32:339–349. [PMC free article] [PubMed] [Google Scholar]
  7. Bennett A., Stamford I. F., Unger W. G. Prostaglandin E2 and gastric acid secretion in man. J Physiol. 1973 Mar;229(2):349–360. doi: 10.1113/jphysiol.1973.sp010142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bowen J. C., Kuo Y. J., Pawlik W., Williams D., Shanbour L. L., Jacobson E. D. Electrophysiological effects of burimamide and 16,16-dimethyl prostaglandin E2 on the canine gastric mucosa. Gastroenterology. 1975 Jun;68(6):1480–1484. [PubMed] [Google Scholar]
  9. Brodie D. A., Chase B. J. Evaluation of gastric acid as a factor in drug-induced gastric hemorrhage in the rat. Gastroenterology. 1969 Feb;56(2):206–213. [PubMed] [Google Scholar]
  10. Brodie D. A., Chase B. J. Role of gastric acid in aspirin-induced gastric irritation in the rat. Gastroenterology. 1967 Oct;53(4):604–610. [PubMed] [Google Scholar]
  11. Brodie D. A., Cook P. G., Bauer B. J., Dagle G. E. Indomethacin-induced intestinal lesions in the rat. Toxicol Appl Pharmacol. 1970 Nov;17(3):615–624. doi: 10.1016/0041-008x(70)90036-0. [DOI] [PubMed] [Google Scholar]
  12. Bugat R., Thompson M. R., Aures D., Grossman M. I. Gastric mucosal lesions produced by intravenous infusion of aspirin in cats. Gastroenterology. 1976 Nov;71(5):754–759. [PubMed] [Google Scholar]
  13. Chaudhury T. K., Jacobson E. D. Prostaglandin cytoprotection of gastric mucosa. Gastroenterology. 1978 Jan;74(1):58–63. [PubMed] [Google Scholar]
  14. Cheung L. Y., Moody F. G., Reese R. S. Effect of aspirin, bile salt, and ethanol on canine gastric mucosal blood flow. Surgery. 1975 Jun;77(6):786–792. [PubMed] [Google Scholar]
  15. Cohen M. M., Pollett J. M. Prostaglandin E2 prevents aspirin and indomethacin damage to human gastric mucosa. Surg Forum. 1976;27(62):400–401. [PubMed] [Google Scholar]
  16. Collier H. O., McDonald-Gibson W. J., Saeed S. A. Letter: Stimulation of prostaglandin biosynthesis by capsaicin, ethanol, and tyramine. Lancet. 1975 Mar 22;1(7908):702–702. doi: 10.1016/s0140-6736(75)91818-8. [DOI] [PubMed] [Google Scholar]
  17. Cummings J. H., Newman A., Misiewicz J. J., Milton-Thompson G. J., Billings J. A. Effect of intravenous prostaglandin F 2 on small intestinal function in man. Nature. 1973 May 18;243(5403):169–171. doi: 10.1038/243169a0. [DOI] [PubMed] [Google Scholar]
  18. Davenport H. W. Gastric mucosal hemorrhage in dogs. Effects of acid, aspirin, and alcohol. Gastroenterology. 1969 Mar;56(3):439–449. [PubMed] [Google Scholar]
  19. Davenport H. W., Munro D. Aminopyrine clearance in the damaged gastric mucosa: reconciliation of conflicting data. Gastroenterology. 1973 Sep;65(3):512–514. [PubMed] [Google Scholar]
  20. Davenport H. W. Salicylate damage to the gastric mucosal barrier. N Engl J Med. 1967 Jun 8;276(23):1307–1312. doi: 10.1056/NEJM196706082762308. [DOI] [PubMed] [Google Scholar]
  21. Djahanguiri B. The production of acute gastric ulceration by indomethacin in the rat. Scand J Gastroenterol. 1969;4(3):265–267. [PubMed] [Google Scholar]
  22. Dozois R. R., Thompson C. J. Proceedings: Release of prostaglandins in canine gastric secretions in response to graded pentagastrin stimulation. Br J Pharmacol. 1974 Sep;52(1):151P–151P. [PMC free article] [PubMed] [Google Scholar]
  23. Elegbe R. A. Prevention by two anticholinergic drugs of indomethacin-induced gastric mucosal ulceration in rats. Isr J Med Sci. 1974 Nov;10(11):1451–1454. [PubMed] [Google Scholar]
  24. Fang W. F., Broughton A., Jacobson E. D. Indomethacin-induced intestinal inflammation. Am J Dig Dis. 1977 Sep;22(9):749–760. doi: 10.1007/BF01694504. [DOI] [PubMed] [Google Scholar]
  25. Ferguson W. W., Edmonds A. W., Starling J. R., Wangensteen S. L. Protective effect of prostaglandin E 1 (PGE 1 ) on lysosomal enzyme release in serotonin-induced gastric ulceration. Ann Surg. 1973 Jun;177(6):648–654. doi: 10.1097/00000658-197306000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Fung W. P., Karim S. M. Effect of 15 (R) 15 methyl prostaglandin E2 on the healing of gastric ulcers: a double-blind endoscopic study. Med J Aust. 1976 Jul 24;2(4):127–128. doi: 10.5694/j.1326-5377.1976.tb130072.x. [DOI] [PubMed] [Google Scholar]
  27. Gibiński K., Rybicka J., Mikoś E., Nowak A. Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues. Gut. 1977 Aug;18(8):636–639. doi: 10.1136/gut.18.8.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Gryglewski R. J., Panczenko B., Korbut R., Grodzinska L., Ocetkiewicz A. Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. Prostaglandins. 1975 Aug;10(2):343–355. doi: 10.1016/0090-6980(75)90053-2. [DOI] [PubMed] [Google Scholar]
  29. Hall W. J., O'Donoghue J. P., O'Regan M. G., Penny W. J. Endogenous prostaglandins, adenosine 3':5'-monophosphate and sodium transport across isolated frog skin. J Physiol. 1976 Jul;258(3):731–753. doi: 10.1113/jphysiol.1976.sp011443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Ippoliti A. F., Isenberg J. I., Maxwell V., Walsh J. H. The effect of 16,16-dimethyl prostaglandin E2 on meal-stimulated gastric acid secretion and serum gastrin in duodenal ulcer patients. Gastroenterology. 1976 Apr;70(4):488–491. [PubMed] [Google Scholar]
  31. Jacobson E. D., Thompson W. J. Cyclic AMP and gastric secretion: the illusive second messenger. Adv Cyclic Nucleotide Res. 1976;7:199–224. [PubMed] [Google Scholar]
  32. Kent T. H., Cardelli R. M., Stamler F. W. Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol. 1969 Feb;54(2):237–249. [PMC free article] [PubMed] [Google Scholar]
  33. Konturek S. J., Kwiecień N., Swierczek J., Oleksy J., Sito E., Robert A. Comparison of methylated prostaglandin E2 analogues given orally in the inhibition of gastric responses to pentagastrin and peptone meal in man. Gastroenterology. 1976 May;70(5 PT1):683–687. [PubMed] [Google Scholar]
  34. Kuo Y. J., Shanbour L. L. Inhibition of ion transport by bile salts in canine gastric mucosa. Am J Physiol. 1976 Nov;231(5 Pt 1):1433–1437. doi: 10.1152/ajplegacy.1976.231.5.1433. [DOI] [PubMed] [Google Scholar]
  35. Kuo Y. J., Shanbour L. L. Mechanism of action of aspirin on canine gastric mucosa. Am J Physiol. 1976 Mar;230(3):762–767. doi: 10.1152/ajplegacy.1976.230.3.762. [DOI] [PubMed] [Google Scholar]
  36. Kuo Y. J., Shanbour L. L., Sernka T. J. Effect of ethanol on permeability and ion transport in the isolated dog stomach. Am J Dig Dis. 1974 Sep;19(9):818–824. doi: 10.1007/BF01071941. [DOI] [PubMed] [Google Scholar]
  37. LEVRAT M., LAMBERT R. Aspirin, gastrointestinal bleeding, and peptic ulcer. Am J Dig Dis. 1960 Jul;5:623–631. doi: 10.1007/BF02290196. [DOI] [PubMed] [Google Scholar]
  38. Lee Y. H., Cheng W. D., Bianchi R. G., Mollison K., Hansen J. Effects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerations. Prostaglandins. 1973 Jan;3(1):29–45. doi: 10.1016/0090-6980(73)90135-4. [DOI] [PubMed] [Google Scholar]
  39. Lee Y. H., Mollison K. W., Cheng W. D. The effects of anti-ulcer agents on indomethacin-induced gastric ulceration in the rat. Arch Int Pharmacodyn Ther. 1971 Aug;192(2):370–377. [PubMed] [Google Scholar]
  40. Lewis G. P., Piper P. J. Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids. Nature. 1975 Mar 27;254(5498):308–311. doi: 10.1038/254308a0. [DOI] [PubMed] [Google Scholar]
  41. Lin T. M., Warrick M. W. Action of acetylsalicylic acid and glucagon on acid secretion mucosal blood flow, bleeding and net ionic efflux in the fundic pouch of pentagastrin-stimulated dogs. Arch Int Pharmacodyn Ther. 1974 Aug;210(2):279–287. [PubMed] [Google Scholar]
  42. Lin T. M., Warrick M. W., Evans D. C., Nash J. F. Action of the anti-inflammatory agents, acetylsalicylic acid, indomethacin and fenoprofen on the gastric mucosa of dogs. Res Commun Chem Pathol Pharmacol. 1975 May;11(1):1–14. [PubMed] [Google Scholar]
  43. Lippmann W. Inhibition of indomethacin-induced gastric ulceration in the rat by perorally-administered synthetic and natural prostaglandin analogues. Prostaglandins. 1974 Jul 10;7(1):1–10. doi: 10.1016/s0090-6980(74)80072-9. [DOI] [PubMed] [Google Scholar]
  44. Lipson L. C., Sharp G. W. Effect of prostaglandin E1 on sodium transport and osmotic water flow in the toad bladder. Am J Physiol. 1971 Apr;220(4):1046–1052. doi: 10.1152/ajplegacy.1971.220.4.1046. [DOI] [PubMed] [Google Scholar]
  45. MAUER E. F. The toxic effects of phenylbutazone (butazolidin); review of the literature and report of the twenty-third death following its use. N Engl J Med. 1955 Sep 8;253(10):404–410. doi: 10.1056/NEJM195509082531003. [DOI] [PubMed] [Google Scholar]
  46. Main I. H., Whittle B. J. Effects of indomethacin on rat gastric acid secretion and mucosal blood flow. Br J Pharmacol. 1973 Mar;47(3):666P–666P. [PMC free article] [PubMed] [Google Scholar]
  47. Main I. H., Whittle B. J. The effects E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat. Br J Pharmacol. 1973 Nov;49(3):428–436. doi: 10.1111/j.1476-5381.1973.tb17253.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Mann N. S. Bile-induced acute erosive gastritis. Its prevention by antacid, cholestyramine, and prostaglandin E2. Am J Dig Dis. 1976 Feb;21(2):89–92. doi: 10.1007/BF01072047. [DOI] [PubMed] [Google Scholar]
  49. Matuchansky C., Bernier J. J. Effect of prostaglandin E 1 on glucose, water, and electrolyte absorption in the human jejunum. Gastroenterology. 1973 Jun;64(6):1111–1118. [PubMed] [Google Scholar]
  50. Matuchansky C., Bernier J. J. Effects of prostaglandin E1 on net and unidirectional movements of water and electrolytes across the jejunal mucosa in man. Gut. 1971 Oct;12(10):854–855. [PubMed] [Google Scholar]
  51. Messina E. J., Weiner R., Kaley G. Inhibition of bradykinin vasodilation and potentiation of norepinephrine and angiotensin vasoconstriction by inhibitors of prostaglandin synthesis in skeletal muscle of the rat. Circ Res. 1975 Oct;37(4):430–437. doi: 10.1161/01.res.37.4.430. [DOI] [PubMed] [Google Scholar]
  52. Nezamis J. E., Robert A., Stowe D. F. Inhibition by prostaglandin E 1 of gastric secretion in the dog. J Physiol. 1971 Oct;218(2):369–383. doi: 10.1113/jphysiol.1971.sp009623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Nicoloff D. M. Indomethacin. Effect on gastric secretion, parietal cell population, and ulcer provocation in the dog. Arch Surg. 1968 Nov;97(5):809–815. doi: 10.1001/archsurg.1968.01340050149024. [DOI] [PubMed] [Google Scholar]
  54. O'Brien P. E., Carter D. C. Effect of gastric secretory inhibitors on the gastric mucosal barrier. Gut. 1975 Jun;16(6):437–442. doi: 10.1136/gut.16.6.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. O'Brien P., Silen W. Effect of bile salts and aspirin on the gastric mucosal blood flow. Gastroenterology. 1973 Feb;64(2):246–253. [PubMed] [Google Scholar]
  56. Ozdemir I. A., Zimmermann B. Serotonin and restraint-induced gastrointestinal ulceration and microcirculatory ischemia. Surg Forum. 1971;22:319–320. [PubMed] [Google Scholar]
  58. Parry D. J., Wood P. H. Relationship between aspirin taking and gastroduodenal haemorrhage. Gut. 1967 Jun;8(3):301–307. doi: 10.1136/gut.8.3.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Peskar B. M., Holland A., Peskar B. A. Quantitative determination of prostaglandins in human gastric juice by radioimmunoassay. Clin Chim Acta. 1974 Aug 30;55(1):21–27. doi: 10.1016/0009-8981(74)90329-5. [DOI] [PubMed] [Google Scholar]
  60. Pierce N. F., Carpenter C. C., Jr, Elliott H. L., Greenough W. B., 3rd Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum. Gastroenterology. 1971 Jan;60(1):22–32. [PubMed] [Google Scholar]
  61. Price W. E., Rohrer G. V., Jacobson E. D. Mesenteric vascular diseases. Gastroenterology. 1969 Nov;57(5):599–604. [PubMed] [Google Scholar]
  62. Ritchie W. P., Jr Acute gastric mucosal damage induced by bile salts, acid, and ischemia. Gastroenterology. 1975 Apr;68(4 Pt 1):699–707. [PubMed] [Google Scholar]
  63. Robert A. An intestinal disease produced experimentally by a prostaglandin deficiency. Gastroenterology. 1975 Oct;69(4):1045–1047. [PubMed] [Google Scholar]
  64. Robert A. Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins. Adv Prostaglandin Thromboxane Res. 1976;2:507–520. [PubMed] [Google Scholar]
  65. Robert A. Effects of prostaglandins on the stomach and the intestine. Prostaglandins. 1974 Jun 25;6(6):523–532. doi: 10.1016/s0090-6980(74)80062-6. [DOI] [PubMed] [Google Scholar]
  66. Robert A., Nezamis J. E., Phillips J. P. Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat. Gastroenterology. 1968 Oct;55(4):481–487. [PubMed] [Google Scholar]
  67. Robert A., Nezamis J. E., Phillips J. P. Inhibition of gastric secretion by prostaglandins. Am J Dig Dis. 1967 Oct;12(10):1073–1076. doi: 10.1007/BF02233268. [DOI] [PubMed] [Google Scholar]
  68. Robert A., Schultz J. R., Nezamis J. E., Lancaster C. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology. 1976 Mar;70(3):359–370. [PubMed] [Google Scholar]
  69. Robert A., Stowe D. F., Nezamis J. E. Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ). Scand J Gastroenterol. 1971;6(4):303–305. doi: 10.3109/00365527109181124. [DOI] [PubMed] [Google Scholar]
  70. Rothermich N. O. An extended study of indomethacin. I. Clinical pharmacology. JAMA. 1966 Feb 14;195(7):531–536. [PubMed] [Google Scholar]
  71. Sernka T. J., Gilleland C. W., Shanbour L. L. Effects of ethanol on active transport in the dog stomach. Am J Physiol. 1974 Feb;226(2):397–400. doi: 10.1152/ajplegacy.1974.226.2.397. [DOI] [PubMed] [Google Scholar]
  72. Silen W. Founder's lecture: New concepts of the gastric mucosal barrier. Am J Surg. 1977 Jan;133(1):8–12. doi: 10.1016/0002-9610(77)90184-2. [DOI] [PubMed] [Google Scholar]
  73. Takeguchi C., Sih C. J. A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory agents. Prostaglandins. 1972 Sep;2(3):169–184. doi: 10.1016/s0090-6980(72)80021-2. [DOI] [PubMed] [Google Scholar]
  74. Usardi M. M., Franceshini J., Mandelli V., Daturi S., Mizzotti B. Prostaglandins VII: a proposed role for Pge2 in the genesis of stress-induced gastric ulcers. Prostaglandins. 1974 Oct 10;8(1):43–51. doi: 10.1016/0090-6980(74)90035-5. [DOI] [PubMed] [Google Scholar]
  75. VARRO V., CSERNAY L., JAVOR T. Experimental phenylbutzone ulcer in dogs. Gastroenterology. 1959 Oct;37:463–467. [PubMed] [Google Scholar]
  76. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
  77. WATT J., WILSON C. W. Phenylbutazone and gastric ulceration in the guinea pig. Gastroenterology. 1959 Jul;37(1):96–102. [PubMed] [Google Scholar]
  78. WOOD P. H., HARVEY-SMITH E. A., DIXON A. S. Salicylates and gastrointestinal bleeding. Acetylsalicylic acid and aspirin derivatives. Br Med J. 1962 Mar 10;1(5279):669–675. doi: 10.1136/bmj.1.5279.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Wax J., Clinger W. A., Varner P., Bass P., Winder C. V. Relationship of the enterohepatic cycle to ulcerogenesis in the rat small bowel with flufenamic acid. Gastroenterology. 1970 Jun;58(6):772–780. [PubMed] [Google Scholar]
  80. Whittle B. J. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins. Br J Pharmacol. 1977 Jul;60(3):455–460. doi: 10.1111/j.1476-5381.1977.tb07522.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Wilson D. E., Phillips C., Levine R. A. Inhibition of gastric secretion in man by prostaglandin A. Gastroenterology. 1971 Aug;61(2):201–206. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES