Abstract
A chronic colitis has been induced in rabbits having many of the histological features of human ulcerative colitis. Animals were first immunised with the common enterobacterial antigen of Kunin and haemagglutinating antibodies demonstrated in high titre. An immune complex colitis was then established by the injection of soluble immune complexes following mild irritation of the rectum with dilute formalin as previously described. The rabbits developed an acute colitis within the first week but, in contrast with unsensitised rabbits, the inflammation persisted and was still present at six months as assessed by proctoscopy and rectal biopsy. Kunin-sensitised rabbits receiving intravenous saline, antigen, or antibody alone did not develop a chronic colitis. It is suggested that hypersensitivity to colonic bacterial antigens may be one mechanism whereby an acute colitis becomes chronic.
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- BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bartnik W., Swarbrick E. T., Williams C. A study of peripheral leucocyte migration in agarose medium in inflammatory bowel disease. Gut. 1974 Apr;15(4):294–300. doi: 10.1136/gut.15.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bull D. M., Ignaczak T. F. Enterobacterial common antigen-induced lymphocyte reactivity in inflammatory bowel disease. Gastroenterology. 1973 Jan;64(1):43–50. [PubMed] [Google Scholar]
- Cooke E. M., Filipe M. I., Dawson I. M. The production of colonic auto-antibodies in rabbits by immunisation with Escherichia coli. J Pathol Bacteriol. 1968 Jul;96(1):125–130. doi: 10.1002/path.1700960113. [DOI] [PubMed] [Google Scholar]
- Hodgson H. J., Potter B. J., Jewell D. P. C3 metabolism in ulcerative colitis and Crohn's disease. Clin Exp Immunol. 1977 Jun;28(3):490–495. [PMC free article] [PubMed] [Google Scholar]
- Hodgson H. J., Potter B. J., Jewell D. P. Immune complexes in ulcerative colitis and Crohn's disease. Clin Exp Immunol. 1977 Aug;29(2):187–196. [PMC free article] [PubMed] [Google Scholar]
- Hodgson H. J., Potter B. J., Skinner J., Jewell D. P. Immune-complex mediated colitis in rabbits. An experimental model. Gut. 1978 Mar;19(3):225–232. doi: 10.1136/gut.19.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lagercrantz R., Hammarström S., Perlmann P., Gustafsson B. E. Immunological studies in ulcerative colitis. IV. Origin of autoantibodies. J Exp Med. 1968 Dec 1;128(6):1339–1352. doi: 10.1084/jem.128.6.1339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Monteiro E., Fossey J., Shiner M., Drasar B. S., Allison A. C. Antibacterial antibodies in rectal and colonic mucosa in ulcerative colitis. Lancet. 1971 Feb 6;1(7693):249–250. doi: 10.1016/s0140-6736(71)90997-4. [DOI] [PubMed] [Google Scholar]
- Perlmann P., Hammarström S., Lagercrantz R., Gustafsson B. E. Antigen from colon of germfree rats and antibodies in human ulcerative colitis. Ann N Y Acad Sci. 1965 Jun 30;124(1):377–394. doi: 10.1111/j.1749-6632.1965.tb18972.x. [DOI] [PubMed] [Google Scholar]