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. 1979 Jan;20(1):55–58. doi: 10.1136/gut.20.1.55

Jejunal lysozyme activity and the Paneth cell in coeliac disease.

M Ward, A Ferguson, M A Eastwood
PMCID: PMC1418968  PMID: 761838

Abstract

The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cornell H. J., Townley R. R. Investigation of possible intestinal peptidase deficiency in coeliac disease. Clin Chim Acta. 1973 Jan 10;43(1):113–125. doi: 10.1016/0009-8981(73)90126-5. [DOI] [PubMed] [Google Scholar]
  2. Creamer B. Paneth-cell function. Lancet. 1967 Feb 11;1(7485):314–316. doi: 10.1016/s0140-6736(67)91245-7. [DOI] [PubMed] [Google Scholar]
  3. Creamer B., Pink I. J. Paneth-cell deficiency. Lancet. 1967 Feb 11;1(7485):304–306. doi: 10.1016/s0140-6736(67)91239-1. [DOI] [PubMed] [Google Scholar]
  4. DAHLQVIST A. METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES. Anal Biochem. 1964 Jan;7:18–25. doi: 10.1016/0003-2697(64)90115-0. [DOI] [PubMed] [Google Scholar]
  5. Douglas A. P., Booth C. C. Digestion of gluten peptides by normal human jejunal mucosa and by mucosa from patients with adult coeliac disease. Clin Sci. 1970 Jan;38(1):11–25. doi: 10.1042/cs0380011. [DOI] [PubMed] [Google Scholar]
  6. Erlandsen S. L., Chase D. G. Paneth cell function: phagocytosis and intracellular digestion of intestinal microorganisms. I. Hexamita muris. J Ultrastruct Res. 1972 Nov;41(3):296–318. doi: 10.1016/s0022-5320(72)90071-8. [DOI] [PubMed] [Google Scholar]
  7. Erlandsen S. L., Parsons J. A., Taylor T. D. Ultrastructural immunocytochemical localization of lysozyme in the Paneth cells of man. J Histochem Cytochem. 1974 Jun;22(6):401–413. doi: 10.1177/22.6.401. [DOI] [PubMed] [Google Scholar]
  8. Kudinova T. I. Lizotsim kak faktor mestnoi zashchity v zheludochnokishechnom trakte bol'nykh s khronicheskimi zabolevaniiami organov pishchevareniia. Antibiotiki. 1976 May;21(5):441–444. [PubMed] [Google Scholar]
  9. Mallas E., Terry J. M., Asquith P., Cooke W. T. Serum lysozyme in inflammatory bowel and coeliac disease. J Clin Pathol. 1976 Jul;29(7):598–600. doi: 10.1136/jcp.29.7.598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Osserman E. F., Klockars M., Halper J., Fischel R. E. Effects of lysozyme on normal and transformed mammalian cells. Nature. 1973 Jun 8;243(5406):331–335. doi: 10.1038/243331a0. [DOI] [PubMed] [Google Scholar]
  11. Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966 Nov 1;124(5):921–952. doi: 10.1084/jem.124.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Peeters T., Vantrappen G. The Paneth cell: a source of intestinal lysozyme. Gut. 1975 Jul;16(7):553–558. doi: 10.1136/gut.16.7.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Toner P. G. Cytology of intestinal epithelial cells. Int Rev Cytol. 1968;24:233–343. doi: 10.1016/s0074-7696(08)61401-1. [DOI] [PubMed] [Google Scholar]

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