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. 1980 May;21(5):397–401. doi: 10.1136/gut.21.5.397

Genetic studies in human and murine giardiasis.

I C Roberts-Thomson, G F Mitchell, R F Anders, B D Tait, P Kerlin, A Kerr-Grant, P Cavanagh
PMCID: PMC1419092  PMID: 6933131

Abstract

Genetic markers were analysed in 48 adults who appeared to have a prolonged infection with Giardia lamblia. The frequency of ABO blood groups, Rhesus blood groups, and Gm phenotypes was similar to that in control subjects. However, there was a higher than expected frequency of HLA antigens A1 (observed 46 . 7%, expected 32%) and B12 (observed 47 . 8%, expected 25 . 8%) and a higher than expected frequency of the phenotypes A1/A2 and B12/B27. Genetic studies were also performed with inbred strains of mice showing relatively rapid (BALB/c) and defective (C3H/He) spontaneous elimination of Giardia muris. From analysis in backcross mice several genes appeared to influence susceptibility to prolonged infection with G. muris.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alp M. H., Hislop I. G. The effect of Giardia lamblia infestation on the gastro-intestinal tract. Australas Ann Med. 1969 Aug;18(3):232–237. doi: 10.1111/imj.1969.18.3.232. [DOI] [PubMed] [Google Scholar]
  2. Barnes G. L., Kay R. Blood-groups in giardiasis. Lancet. 1977 Apr 9;1(8015):808–808. doi: 10.1016/s0140-6736(77)92999-3. [DOI] [PubMed] [Google Scholar]
  3. Brackertz D., Mitchell G. F., Mackay I. R. Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum. 1977 Apr;20(3):841–850. doi: 10.1002/art.1780200314. [DOI] [PubMed] [Google Scholar]
  4. Eidinger D., Garrett T. J. Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation. J Exp Med. 1972 Nov 1;136(5):1098–1116. doi: 10.1084/jem.136.5.1098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kerlin P., Ratnaike R. N., Butler R., Grant N. G. Prevalence of Giardiasis: a study at upper-gastrointestinal endoscopy. Am J Dig Dis. 1978 Oct;23(10):940–942. doi: 10.1007/BF01072471. [DOI] [PubMed] [Google Scholar]
  6. Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
  7. Natsuume-Sakai S., Motonishi K., Migita S. Quantitative estimations of five classes of immunoglobulin in inbred mouse strains. Immunology. 1977 Jun;32(6):861–866. [PMC free article] [PubMed] [Google Scholar]
  8. Pandey J. P., Fudenberg H. H., Virella G., Kyong C. U., Loadholt C. B., Galbraith R. M., Gotschlich E. C., Parke J. C., Jr Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides. Lancet. 1979 Jan 27;1(8109):190–192. doi: 10.1016/s0140-6736(79)90584-1. [DOI] [PubMed] [Google Scholar]
  9. RENDTORFF R. C. The experimental transmission of human intestinal protozoan parasites. II. Giardia lamblia cysts given in capsules. Am J Hyg. 1954 Mar;59(2):209–220. doi: 10.1093/oxfordjournals.aje.a119634. [DOI] [PubMed] [Google Scholar]
  10. Roberts-Thomson I. C., Mitchell G. F. Giardiasis in mice. I. Prolonged infections in certain mouse strains and hypothymic (nude) mice. Gastroenterology. 1978 Jul;75(1):42–46. [PubMed] [Google Scholar]
  11. Roberts-Thomson I. C., Stevens D. P., Mahmoud A. A., Warren K. S. Giardiasis in the mouse: an animal model. Gastroenterology. 1976 Jul;71(1):57–61. [PubMed] [Google Scholar]
  12. Slonim J. M., Ireton H. J., Smallwood R. A. Giardiasis following gastric surgery. Aust N Z J Med. 1976 Oct;6(5):479–480. doi: 10.1111/j.1445-5994.1976.tb03040.x. [DOI] [PubMed] [Google Scholar]
  13. Svejgaard A., Jersild C., Nielsen L. S., Bodmer W. F. HL-A antigens and disease. Statistical and genetical considerations. Tissue Antigens. 1974;4(2):95–105. doi: 10.1111/j.1399-0039.1974.tb00230.x. [DOI] [PubMed] [Google Scholar]
  14. WEBSTER B. H. Human infection with Giardia lamblia; an analysis of 32 cases. Am J Dig Dis. 1958 Jan;3(1):64–71. doi: 10.1007/BF02231310. [DOI] [PubMed] [Google Scholar]
  15. Webster A. D. The gut and immunodeficiency disorders. Clin Gastroenterol. 1976 May;5(2):323–340. [PubMed] [Google Scholar]
  16. Wells J. V., Fudenberg H. H., MacKay I. R. RElation of the human antibody response to flagellin to GM genotype. J Immunol. 1971 Dec;107(6):1505–1511. [PubMed] [Google Scholar]
  17. Whittingham S., Mathews J. D., Schanfield M. S., Matthews J. V., Tait B. D., Morris P. J., Mackay I. R. Interactive effect of Gm allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigen. Clin Exp Immunol. 1980 Apr;40(1):8–15. [PMC free article] [PubMed] [Google Scholar]
  18. YARDLEYJHTAKANO J., HENDRIX T. R. EPITHELIAL AND OTHER MUCOSAL LESIONS OF THE JEJUNUM IN GIARDIASIS. JEJUNAL BIOPSY STUDIES. Bull Johns Hopkins Hosp. 1964 Nov;115:389–406. [PubMed] [Google Scholar]
  19. Zisman M. Blood-group A and giardiasis. Lancet. 1977 Dec 17;2(8051):1285–1285. doi: 10.1016/s0140-6736(77)92689-7. [DOI] [PubMed] [Google Scholar]

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