Abstract
Of 30 patients with chronic liver disease 16 showed some degree of impairment of glucose tolerance, and 16 patients had lack of suppression of raised fasting growth hormone levels or showed an anomalous rise after oral glucose. No relationship, however, existed between the state of glucose tolerance and the presence of abnormal growth hormone levels. Plasma glucose in those with normal growth hormone response at 0, 1/2, 1, 1-1/2, and 2 hours, after 50 g glucose were 5.55 +/- 0.41 mmol/l, 8.71 +/- 0.59, 10.66 +/- 0.99, 10.28 +/- 1.37, 8.90 +/- 1.40 (mean +/- SEM; n = 14). Under the same conditions those with abnormal growth hormone responses showed values of 5.32 +/- 0.59, 7.83 +/- 0.81, 9.41 +/- 0.95, 9.46 +/- 0.99, 8.69 +/- 0.98. At no time were the differences significantly different as judged by Student's t test. Measurement of serum insulin indicated a relative deficiency in patients with impaired tolerance. It is concluded that the abnormal growth hormone is not directly responsible for the impaired glucose tolerance.
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Selected References
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- Becker M. D., Cook G. C., Wright A. D. Paradoxical elevation of growth hormone in active chronic hepatitis. Lancet. 1969 Nov 15;2(7629):1035–1039. doi: 10.1016/s0140-6736(69)90643-6. [DOI] [PubMed] [Google Scholar]
- Cameron D. P., Burger H. G., Catt K. J., Gordon E., Watts J. M. Metabolic clearance of human growth hormone in patients with hepatic and renal failure, and in the isolated perfused pig liver. Metabolism. 1972 Oct;21(10):895–904. doi: 10.1016/0026-0495(72)90024-8. [DOI] [PubMed] [Google Scholar]
- Conn H. O., Daughaday W. H. Cirrhosis and diabetes. V. Serum human growth hormone levels in Laennec's cirrhosis. J Lab Clin Med. 1970 Oct;76(4):678–688. [PubMed] [Google Scholar]
- Cudworth A. G., Woodrow J. C. HL-A system and diabetes mellitus. Diabetes. 1975 Apr;24(4):345–349. doi: 10.2337/diab.24.4.345. [DOI] [PubMed] [Google Scholar]
- Galbraith R. M., Eddleston A. L., Smith M. G., Williams R., McSween R. N., Watkinson G., Dick H., Kennedy L. A., Batchelor J. R. Histocompatibility antigens in active chronic hepatitis and primary biliary cirrhosis. Br Med J. 1974 Sep 7;3(5931):604–605. doi: 10.1136/bmj.3.5931.604. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greco A. V., Ghirlanda G., Patrono C., Fedili G., Manna R. Behavior of pancreatic glucagon, insulin, and HGH in liver cirrhosis, after arginine and I.V. glucose. Acta Diabetol Lat. 1974 Jul-Aug;11(4):330–339. doi: 10.1007/BF02581236. [DOI] [PubMed] [Google Scholar]
- Megyesi C., Samols E., Marks V. Glucose tolerance and diabetes in chronic liver disease. Lancet. 1967 Nov 18;2(7525):1051–1056. doi: 10.1016/s0140-6736(67)90334-0. [DOI] [PubMed] [Google Scholar]
- Nerup J., Platz P., Andersen O. O., Christy M., Lyngsoe J., Poulsen J. E., Ryder L. P., Nielsen L. S., Thomsen M., Svejgaard A. HL-A antigens and diabetes mellitus. Lancet. 1974 Oct 12;2(7885):864–866. doi: 10.1016/s0140-6736(74)91201-x. [DOI] [PubMed] [Google Scholar]
- Samaan N. A., Stone D. B., Eckhardt R. D. Serum glucose, insulin, and growth hormone in chronic hepatic cirrhosis. Arch Intern Med. 1969 Aug;124(2):149–152. [PubMed] [Google Scholar]
- Taylor A. L., Lipman R. L., Salam A., Mintz D. H. Hepatic clearance of human growth hormone. J Clin Endocrinol Metab. 1972 Feb;34(2):395–399. doi: 10.1210/jcem-34-2-395. [DOI] [PubMed] [Google Scholar]
- Zanoboni A., Zanoboni-Muciaccia W. Elevated basal growth hormone levels and growth hormone response to TRH in alcoholic patients with cirrhosis. J Clin Endocrinol Metab. 1977 Sep;45(3):576–578. doi: 10.1210/jcem-45-3-576. [DOI] [PubMed] [Google Scholar]