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. 1981 May;22(5):345–349. doi: 10.1136/gut.22.5.345

Results of portal decompression in patients with primary biliary cirrhosis.

R Spinsi, G Smith-Laing, O Epstein, S Sherlock
PMCID: PMC1419244  PMID: 7250744

Abstract

Twenty-five patients with primary biliary cirrhosis undergoing portal decompression have been followed up for a mean of 51 months. Five patients with decompensated cirrhosis died postoperatively. Overall five year survival of 66% is comparable with that for other forms of cirrhosis but none of the long-term survivors, including three patients with a precirrhotic stage of primary biliary cirrhosis at the time of surgery, developed significant portal-systemic encephalopathy. The results suggest that portal decompression may be the therapy of choice for patients with well-compensated primary biliary cirrhosis who suffer recurrent variceal haemorrhage.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer J. J., Gelernt I. M., Kreel I. Portosystemic shunting in patients with primary biliary cirrhosis: a good risk disease. Ann Surg. 1976 Mar;183(3):324–328. doi: 10.1097/00000658-197603000-00020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Drapanas T. Interposition mesocaval shunt for treatment of portal hypertension. Ann Surg. 1972 Oct;176(4):435–448. doi: 10.1097/00000658-197210000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Epstein O., De Villiers D., Jain S., Potter B. J., Thomas H. C., Sherlock S. Reduction of immune complexes and immunoglobulins induced by D-penicillamine in primary biliary cirrhosis. N Engl J Med. 1979 Feb 8;300(6):274–278. doi: 10.1056/NEJM197902083000602. [DOI] [PubMed] [Google Scholar]
  4. Fleming C. R., Ludwig J., Dickson E. R. Asymptomatic primary biliary cirrhosis. Presentation, histology, and results with D-penicillamine. Mayo Clin Proc. 1978 Sep;53(9):587–593. [PubMed] [Google Scholar]
  5. Hourigan K., Sherlock S., George P., Mindel S. Elective end-to-side portacaval shunt: results in 64 cases. Br Med J. 1971 Nov 20;4(5785):473–477. doi: 10.1136/bmj.4.5785.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kanel G. C., Kaplan M. M., Zawacki J. K., Callow A. D. Survival in patients with postnecrotic cirrhosis and Laennec's cirrhosis undergoing therapeutic portacaval shunt. Gastroenterology. 1977 Oct;73(4 Pt 1):679–683. [PubMed] [Google Scholar]
  7. Kew M. C., Varma R. R., Dos Santos H. A., Scheuer P. J., Sherlock S. Portal hypertension in primary biliary cirrhosis. Gut. 1971 Oct;12(10):830–834. doi: 10.1136/gut.12.10.830. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Long R. G., Scheuer P. J., Sherlock S. Presentation and course of asymptomatic primary biliary cirrhosis. Gastroenterology. 1977 Jun;72(6):1204–1207. [PubMed] [Google Scholar]
  9. Mutchnick M. G., Lerner E., Conn H. O. Portal-systemic encephalopathy and portacaval anastomosis: a prospective, controlled investigation. Gastroenterology. 1974 May;66(5):1005–1019. [PubMed] [Google Scholar]
  10. Pliam M. B., Adson M. A., Foulk W. T. Conventional splenorenal shunts. A reconsideration. Arch Surg. 1975 May;110(5):588–593. doi: 10.1001/archsurg.1975.01360110134022. [DOI] [PubMed] [Google Scholar]
  11. RUBIN E., SCHAFFNER F., POPPER H. PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS. Am J Pathol. 1965 Mar;46:387–407. [PMC free article] [PubMed] [Google Scholar]
  12. Resnick R. H., Chalmers T. C., Ishihara A. M., Garceau A. J., Callow A. D., Schimmel E. M., O'Hara E. T. A controlled study of the prophylactic portacaval shunt. A final report. Ann Intern Med. 1969 Apr;70(4):675–688. doi: 10.7326/0003-4819-70-4-675. [DOI] [PubMed] [Google Scholar]
  13. Resnick R. H., Iber F. L., Ishihara A. M., Chalmers T. C., Zimmerman H. A controlled study of the therapeutic portacaval shunt. Gastroenterology. 1974 Nov;67(5):843–857. [PubMed] [Google Scholar]
  14. Reynolds T. B. Editorial: Promises. Promises. Hemodynamics and portal-systemic shunt. N Engl J Med. 1974 Jun 27;290(26):1484–1485. doi: 10.1056/NEJM197406272902611. [DOI] [PubMed] [Google Scholar]
  15. SHERLOCK S. Primary billiary cirrhosis (chronic intrahepatic obstructive jaundice). Gastroenterology. 1959 Nov;37:574–586. [PubMed] [Google Scholar]
  16. Scheuer P. Primary biliary cirrhosis. Proc R Soc Med. 1967 Dec;60(12):1257–1260. doi: 10.1177/003591576706001205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Shapiro J. M., Smith H., Schaffner F. Serum bilirubin: a prognostic factor in primary biliary cirrhosis. Gut. 1979 Feb;20(2):137–140. doi: 10.1136/gut.20.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Zeegen R., Stansfeld A. G., Dawson A. M., Hunt A. H. Bleeding oesophageal varices as the presenting feature in primary bilirary cirrhosis. Lancet. 1969 Jul 5;2(7610):9–12. doi: 10.1016/s0140-6736(69)92595-1. [DOI] [PubMed] [Google Scholar]
  19. Zeegen R., Stansfeld A. G., Dawson A. M., Hunt A. H. Prolonged survival after portal decompression of patients with non-cirrhotic intrahepatic portal hypertension. Gut. 1970 Jul;11(7):610–617. doi: 10.1136/gut.11.7.610. [DOI] [PMC free article] [PubMed] [Google Scholar]

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