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. 1980 Feb;21(2):85–90. doi: 10.1136/gut.21.2.85

Lower oesophageal sphincter response to pentagastrin in chagasic patients with megaoesophagus and megacolon.

W Padovan, R A Godoy, R O Dantas, U G Meneghelli, R B Oliveira, L E Troncon
PMCID: PMC1419352  PMID: 6769753

Abstract

Intraluminal manometric studies were performed in 14 chagasic patients with megaoesophagus, 10 chagasic patients with megacolon, and 15 control subjects. Basal lower oesophageal sphincter pressure was 20.27+/-1.16 mmHg (mean+/-SEM) in controls as compared wtih 15.16+/-1.53 mmHg in chagasics with megaoesophagus and 14.38+/-1.50 mmHg in chagasics with megacolon. Dose-response studies to intravenous pentagastrin showed that the chagasic patients exhibited a lower sensitivity to the stimulant than did the controls, as demonstrated by shifting of the dose-response curve to the right and higher individual values of the dose for half maximal contraction (D50). No difference was noted between the calculated maximal contraction (Vmax) of oesophageal sphincter of controls and chagasics. These data are compatible with the hypothesis of an interaction between pentagastrin and cholinergic nervous excitation on oesophageal sphincteric smooth muscle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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