Skip to main content
NCBI home page
Gut logoLink to Gut
. 1980 Feb;21(2):118–122. doi: 10.1136/gut.21.2.118

Liver disease and the e antigen in HBsAg carriers with chronic renal failure.

G P Coughlin, A G Van Deth, A P Disney, J Hay, A G Wangel
PMCID: PMC1419355  PMID: 7380332

Abstract

This study was undertaken to assess the frequency of development and the stages of evolution of chronic liver disease in patients with renal failure who are chronic carriers of hepatitis B surface antigen. Cirrhosis or chronic active hepatitis developed in five of 21 patients and could not be predicted by the initial histological appearance or by HLA-A and B typing but was associated with the e antigen in four of the five patients. However, the antigen was not a consistent indicator of a poor prognosis, as the four other e antigen positive patients did not develop chronic liver disease during the period of the study. Transmission of hepatitis B to spouses occurred in four cases, was fatal in one instance, and was associated with e antigen in three of the four. Determination of e antigen status in renal unit patients who are carriers of hepatitis B surface antigen may be of value to the patient and his home environment.

Full text

PDF
118

Images in this article

120Fig. 1
on p.120
120Fig. 2
on p.120
121Fig. 3
on p.121
121Fig. 4
on p.121

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Briggs W. A., Lazarus J. M., Birtch A. G., Hampers C. L., Hager E. B., Merrill J. P. Hepatitis affecting hemodialysis and transplant patients. Its considerations and consequences. Arch Intern Med. 1973 Jul;132(1):21–28. [PubMed] [Google Scholar]
  2. Campion E. C., Wangel A. G., Lawrence J. R. Hepatitis B antigen, auto-antibodies and liver disease in a haemodialysis and transplantation unit. Aust N Z J Med. 1975 Aug;5(4):314–318. doi: 10.1111/j.1445-5994.1975.tb03264.x. [DOI] [PubMed] [Google Scholar]
  3. De Groote J., Desmet V. J., Gedigk P., Korb G., Popper H., Poulsen H., Scheuer P. J., Schmid M., Thaler H., Uehlinger E. A classification of chronic hepatitis. Lancet. 1968 Sep 14;2(7568):626–628. doi: 10.1016/s0140-6736(68)90710-1. [DOI] [PubMed] [Google Scholar]
  4. Descamps B., Jungers P., Naret C., Degott C., Zingraff J., Bach J. F. HLA-A1, B8-phenotype association and HBs antigenemia evolution in 440 hemodialyzed patients. Digestion. 1977;15(4):271–277. doi: 10.1159/000198012. [DOI] [PubMed] [Google Scholar]
  5. Fauerholdt L., Asnaes S., Ranek L., Schiodt T., Tygstrup N. Significance of suspected "chronic aggressive hepatitis" in acute hepatitis. Gastroenterology. 1977 Sep;73(3):543–548. [PubMed] [Google Scholar]
  6. Freudenberg J., Baumann H., Arnold W., Berger J., Büschenfelde K. H. HLA in different forms of chronic active hepatitis. A comparison between adult patients and children. Digestion. 1977;15(4):260–270. doi: 10.1159/000198011. [DOI] [PubMed] [Google Scholar]
  7. Freudenberg J., Erdmann K., Meyer zum Büschenfelde, Förster E., Berger J. HL-A bei Lebereerkrankungen. Klin Wochenschr. 1973 Nov;21(1):1075–1076. doi: 10.1007/BF01468323. [DOI] [PubMed] [Google Scholar]
  8. Galbraith R. M., el Sheikh N., Portmann B., Eddleston A. L., Williams R., Parsons V., Bewick M., Ogg C. S. Immune response to HBsAg and the spectrum of liver lesions in HBsAg-positive patients with chronic renal disease. Br Med J. 1976 Jun 19;1(6024):1495–1497. doi: 10.1136/bmj.1.6024.1495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Greenberg H. B., Pollard R. B., Lutwick L. I., Gregory P. B., Robinson W. S., Merigan T. C. Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. N Engl J Med. 1976 Sep 2;295(10):517–522. doi: 10.1056/NEJM197609022951001. [DOI] [PubMed] [Google Scholar]
  10. Koff R. S., Slavin M. M., Connelly J. D., Rosen D. R. Contagiousness of acute hepatitis B. Secondary attack rates in household contacts. Gastroenterology. 1977 Feb;72(2):297–300. [PubMed] [Google Scholar]
  11. London W. T., Di Figlia M., Sutnick A., Blumberg B. S. An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response. N Engl J Med. 1969 Sep 11;281(11):571–578. doi: 10.1056/NEJM196909112811101. [DOI] [PubMed] [Google Scholar]
  12. Mackay I. R., Morris P. J. Association of autoimmune active chronic hepatitis with HL-A1,8. Lancet. 1972 Oct 14;2(7781):793–795. doi: 10.1016/s0140-6736(72)92149-6. [DOI] [PubMed] [Google Scholar]
  13. Magnius L. O., Espmark J. A. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants. J Immunol. 1972 Nov;109(5):1017–1021. [PubMed] [Google Scholar]
  14. Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
  15. Nielsen J. O., Dietrichson O., Juhl E. Incidence and meaning of the "e" determinant among hepatitis-B-antigen positive patients with acute and chronic liver diseases. Report from the Copenhagen Hepatitis Acuta Programme. Lancet. 1974 Oct 19;2(7886):913–915. doi: 10.1016/s0140-6736(74)91127-1. [DOI] [PubMed] [Google Scholar]
  16. Nordenfelt E., Andrén-Sandberg M. Dane particle-associated DNA polymerase and e antigen: relation to chronic hepatitis among carriers of hepatitis B surface antigen. J Infect Dis. 1976 Jul;134(1):85–89. doi: 10.1093/infdis/134.1.85. [DOI] [PubMed] [Google Scholar]
  17. Norkrans G., Magnius L., Iwarson S. e antigen in acute hepatitis B. Br Med J. 1976 Mar 27;1(6012):740–742. doi: 10.1136/bmj.1.6012.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Purcell R. H., London W. T., McAuliffe V. J., Palmer A. E., Kaplan P. M., Gerin J. L., Wagner J., Popper H., Lvovsky E., Wong D. C. Modification of chronic hepatitis-B virus infection in chimpanzees by administration of an interferon inducer. Lancet. 1976 Oct 9;2(7989):757–761. doi: 10.1016/s0140-6736(76)90598-5. [DOI] [PubMed] [Google Scholar]
  19. Scott B. B., Rajah S. M., Losowsky M. S. Histocompatibility antigens in chronic liver disease. Gastroenterology. 1977 Jan;72(1):122–125. [PubMed] [Google Scholar]
  20. Shikata T., Uzawa T., Yoshiwara N., Akatsuka T., Yamazaki S. Staining methods of Australia antigen in paraffin section--detection of cytoplasmic inclusion bodies. Jpn J Exp Med. 1974 Feb;44(1):25–36. [PubMed] [Google Scholar]
  21. Trepo C. G., Magnius L. O., Schaefer R. A., Prince A. M. Detection of e antigen and antibody: correlations with hapatitis B surface and hepatitis B core antigens, liver disease, and outcome in hepatitis B infections. Gastroenterology. 1976 Nov;71(5):804–808. [PubMed] [Google Scholar]
  22. Vogten A. J., Summerskill W. H., Gitnick G. L., Schalm S. W., Smith J. L., Murphy B. L., Maynard J. E. Behaviour of e antigen and antibody during chronic active liver disease. Relation to HB antigen-antibody system and prognosis. Lancet. 1976 Jul 17;2(7977):126–128. doi: 10.1016/s0140-6736(76)92849-x. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES