Abstract
Thirty patients with distal colitis (proctosigmoiditis) in relapse were randonly allocated to twice daily treatment with traditional aqueous hydrocotrisone enemas (Cortenemas) or a suspension of hydrocortisone in an inert foam base (Colifoam). Each treatment contained the same amount of hydrocortisone. Clinical, sigmoidoscopic, and histological response was assessed after two weeks. Both agents were effective, and broadly similar in terms of objective improvement, but subjective improvement was greater with the foam preparation, and several patients expressed a preference to this mode of treatment.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARON J. H., CONNELL A. M., LENNARD-JONES J. E. VARIATION BETWEEN OBSERVERS IN DESCRIBING MUCOSAL APPEARANCES IN PROCTOCOLITIS. Br Med J. 1964 Jan 11;1(5375):89–92. doi: 10.1136/bmj.1.5375.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark M. L. A local foam aerosol in ulcerative colitis. Practitioner. 1977 Jul;219(1309):103–104. [PubMed] [Google Scholar]
- Farmer R. G., Schumacher O. P. Treatment of ulcerative colitis with hydrocrotisone enemas: relationship of hydrocortisone absorption, adrenal suppression, and clinical response. Dis Colon Rectum. 1970 Sep-Oct;13(5):355–361. doi: 10.1007/BF02616754. [DOI] [PubMed] [Google Scholar]
- Farthing M. J., Lennard-jones J. E. Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis. Gut. 1978 Jan;19(1):64–69. doi: 10.1136/gut.19.1.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farthing M. J., Rutland M. D., Clark M. L. Retrograde spread of hydrocortisone containing foam given intrarectally in ulcerative colitis. Br Med J. 1979 Oct 6;2(6194):822–824. doi: 10.1136/bmj.2.6194.822. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee D. A., Taylor G. M., James V. H., Walker G. Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema. Gut. 1979 May;20(5):349–355. doi: 10.1136/gut.20.5.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATTS S. G., GASKELL K. H. Retrograde colonic spread of enemata in ulcerative colitis. Br Med J. 1961 Sep 2;2(5252):614–616. doi: 10.1136/bmj.2.5252.614. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mallett S. J., Lennard-Jones J. E., Bingley J., Gilon E. Colitis. Lancet. 1978 Sep 16;2(8090):619–621. doi: 10.1016/s0140-6736(78)92837-4. [DOI] [PubMed] [Google Scholar]
- Powell-Tuck J., Lennard-Jones J. E., May C. S., Wilson C. G., Paterson J. W. Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis. Br Med J. 1976 Jan 24;1(6003):193–195. doi: 10.1136/bmj.1.6003.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ritchie J. K., Powell-Tuck J., Lennard-Jones J. E. Clinical outcome of the first ten years of ulcerative colitis and proctitis. Lancet. 1978 May 27;1(8074):1140–1143. doi: 10.1016/s0140-6736(78)90312-4. [DOI] [PubMed] [Google Scholar]
- SAMPSON P. A., BROOKE B. N. Absorption of hydrocortisone from the large bowel. Lancet. 1963 Mar 30;1(7283):701–702. doi: 10.1016/s0140-6736(63)91453-3. [DOI] [PubMed] [Google Scholar]
- SHERMAN L. F. THE TREATMENT OF ULCERATIVE COLITIS WITH HYDROCORTISONE ALCOHOL RETENTION ENEMAS. Minn Med. 1965 May;48:605–610. [PubMed] [Google Scholar]
- Scherl N. D., Scherl B. A. Adjunctive use of a steroid rectal foam in the treatment of ulcerative colitis. Dis Colon Rectum. 1973 Mar-Apr;16(2):149–151. doi: 10.1007/BF02589932. [DOI] [PubMed] [Google Scholar]
- TRUELOVE S. C., HAMBLING M. H. Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium; a report on a controlled therapeutic trial. Br Med J. 1958 Nov 1;2(5104):1072–1077. doi: 10.1136/bmj.2.5104.1072. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TRUELOVE S. C. Systemic and local corticosteroid therapy in ulcerative colitis. Br Med J. 1960 Feb 13;1(5171):464–467. doi: 10.1136/bmj.1.5171.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TRUELOVE S. C. Treatment of ulcerative colitis with local hydrocortisone. Br Med J. 1956 Dec 1;2(5004):1267–1272. doi: 10.1136/bmj.2.5004.1267. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATKINSON G. Treatment of ulcerative colitis with topical hydrocortisone hemisuccinate sodium; a controlled trial employing restricted sequential analysis. Br Med J. 1958 Nov 1;2(5104):1077–1082. doi: 10.1136/bmj.2.5104.1077. [DOI] [PMC free article] [PubMed] [Google Scholar]