Skip to main content
Gut logoLink to Gut
. 1980 Dec;21(12):1068–1076. doi: 10.1136/gut.21.12.1068

Possible dietary protective factors in relation to the distribution of duodenal ulcer in India and Bangladesh.

A P Jayaraj, F I Tovey, C G Clark
PMCID: PMC1419402  PMID: 7461465

Abstract

In India there are regions of high incidence and regions of low incidence of duodenal ulcer. Rats prefed for two weeks on diets from low incidence areas developed significantly fewer rumenal ulcers after pyloric ligation than rats fed on diets from high incidence areas. The protective action was found in various individual items of food taken from the diets of low incidence areas. Unrefined wheat and rice, certain pulses (black gram, green gram, horse gram), some millets (sava, kutki, ragi), soya bean, ladies' fingers, cabbage, spinach, and whole cream milk were protective. Refined wheat, polished rice, maize, cornflour, sorghum vulgare, sugar, bananas, amaranthus, brinjal, peanut oil, some pulses (Bengal gram, turdhal), and skimmed milk were non-protective. The protective factor seems to be either a lipid or a liposoluble substance which is active whether given orally or parenterally. Horse gram (Dolichos biflorus) is a particularly potent source.

Full text

PDF
1068

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMI E., MARAZZI-UBERTI E., TURBA C. PHARMACOLOGICAL RESEARCH ON GEFARNATE, A NEW SYNTHETIC ISOPRENOID WITH AN ANTI-ULCER ACTION. Arch Int Pharmacodyn Ther. 1964 Jan 1;147:113–145. [PubMed] [Google Scholar]
  2. CHENEY G. Anti-peptic ulcer dietary factor (vitamin "U") in the treatment of peptic ulcer. J Am Diet Assoc. 1950 Sep;26(9):668–672. [PubMed] [Google Scholar]
  3. CHENEY G. The nature of the antipepticulcer dietary factor. Stanford Med Bull. 1950 Aug;8(3):144–161. [PubMed] [Google Scholar]
  4. CHENEY G. Vitamin U therapy of peptic ulcer. Calif Med. 1952 Oct;77(4):248–252. [PMC free article] [PubMed] [Google Scholar]
  5. Jayaraj A. P., Tovey F. I., Clark C. G. The possibility of dietary protective factors in duodenal ulcer. II. An investigation into the effect of pre-feeding with different diets and of instillation of foodstuffs into the stomach on the incidence of ulcers in pylorus-ligated rats. Postgrad Med J. 1976 Oct;52(612):640–644. doi: 10.1136/pgmj.52.612.640. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Maclaurin B. P., Wardill T. E., Faaiuaso S. T. Environmental aspects of peptic ulcer disease in Western Samoa. N Z Med J. 1979 May 23;89(636):376–378. [PubMed] [Google Scholar]
  7. Maclaurin B. P., Wardill T. E., Faaiuaso S. T., McKinnon M. Geographic distribution of peptic ulcer disease in Western Samoa. N Z Med J. 1979 May 9;89(635):341–344. [PubMed] [Google Scholar]
  8. Malhotra S. L. A comparison of unrefined wheat and rice diets in the management of duodenal ulcer. Postgrad Med J. 1978 Jan;54(627):6–9. doi: 10.1136/pgmj.54.627.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SINGH G. B., ZAIDI S. H., BAJPAI R. P. Effect of Brassica oleracea var. Capitata in the prevention and healing of experimental peptic ulceration. Indian J Med Res. 1962 Sep;50:741–749. [PubMed] [Google Scholar]
  10. Tovey F. I., Jayaraj A. P., Clark C. G. The possibility of dietary protective factors in duodenal ulcer. Postgrad Med J. 1975 Jun;51(596):366–372. doi: 10.1136/pgmj.51.596.366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tovey F. I., Tunstall M. Duodenal ulcer in black populations in Africa south of the Sahara. Gut. 1975 Jul;16(7):564–576. doi: 10.1136/gut.16.7.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tovey F. Peptic ulcer in India and Bangladesh. Gut. 1979 Apr;20(4):329–347. doi: 10.1136/gut.20.4.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WISSMER B. A., ADAMI E. A NEW WAY IN ULCER THERAPY? Curr Ther Res Clin Exp. 1965 Aug;7:474–482. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES