Abstract
Measurements were made of the amounts of histamine extracted from patients with peptic ulcer disease and control subjects suffering from various gastrointestinal diseases. Patients with duodenal ulcer, gastric ulcer, or recurrent duodenal ulcer after proximal gastric vagotomy often had less gastric mucosal histamine than did normal controls. Cimetidine therapy increased the amounts of the histamine to above control levels, presumably by suppression of output. It is concluded that endogenous amounts of histamine reflect the pathogenic states in the gastric mucosa of patients with peptic ulcer diseases. Cimetidine, as does vagotomy, increases the amount of gastric mucosal histamine. These findings suggest that the increase in mucosal histamine with cimetidine is not due to activation of histamine methyl transferase, but rather to suppression of histamine output into the gastric juice.
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Selected References
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- Beraha N., Silveira M., Man W., Silcocks P. B., Spencer J. Catecholamines and experimental stress ulcer: morphological and biochemical changes in the gastric mucosa. Br J Surg. 1980 Sep;67(9):624–628. doi: 10.1002/bjs.1800670906. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Håkanson R., Lilja B., Owman C. Cellular localization of histamine and monoamines in the gastric mucosa of man. Histochemie. 1969 Apr 17;18(1):74–86. doi: 10.1007/BF00309904. [DOI] [PubMed] [Google Scholar]
- Rhode H., Lorenz W., Troidl H., Reimann H. J., Häfner G., Weber D. Histamine and peptic ulcer: influence of sample-taking on the precision and accuracy of fluorometric histamine assay in biopsies of human gastric mucosa. Agents Actions. 1980 Apr;10(1 Pt 2):175–185. doi: 10.1007/BF02024207. [DOI] [PubMed] [Google Scholar]
- Ritchie W. P., Jr, Breen J. J., Grigg D. I. Prevention of stress ulcer by reducing gastric tissue histamine. Surgery. 1967 Oct;62(4):596–600. [PubMed] [Google Scholar]
- Troidl H., Lorenz W., Rohde H., Häfner G., Ronzheimer M. Histamine and peptic ulcer: a prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases. Klin Wochenschr. 1976 Oct 1;54(19):947–956. doi: 10.1007/BF01469008. [DOI] [PubMed] [Google Scholar]
- Troidl H., Rohde H., Lorenz W., Häfner G., Hamelmann H. Effect of selective gastric vagotomy on histamine concentration in gastric mucosa of patients with duodenal ulcer. Br J Surg. 1978 Jan;65(1):10–16. doi: 10.1002/bjs.1800650104. [DOI] [PubMed] [Google Scholar]