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. 1980 Sep;21(9):745–749. doi: 10.1136/gut.21.9.745

Release of vasoactive intestinal peptide by distention of the proximal stomach in dogs.

J A Chayvialle, M Miyata, P L Rayford, J C Thompson
PMCID: PMC1419528  PMID: 7429339

Abstract

The effect of transient proximal gastric distention was studied in six conscious dogs previously submitted to antrectomy and Billroth I anastomosis (and in which the intragastric pH was not altered), and in five anaesthetised dogs prepared with an innervated acute fundic pouch in which the pouch lumen was acidified with 0.15 M hydrochloric acid. Levels of vasoactive intestinal peptide (VIP) in portal and peripheral plasma were measured by radioimmunoassay. In conscious antrectomised dogs, distention of the proximal stomach to volumes of 250 and 500 ml evoked a significant rise of portal VIP concentration, with a maximal variation of 32.7 +/- 4.4 to 67.7 +/- 14.8 pg ml-1, which was hardly reflected in systemic blood. In the anaesthetised dogs, transient distention of the acute fundic pouch with 0.15 M hydrochloric acid under a pressure of 40 cm of water elicited a significant rise of portal VIP from 36.2 +/- 8.9 to 59.8 +/- 12.4 pg ml-1 (P < 0.05) without any significant variation of the peptide concentration in peripheral plasma. These results indicate that vasoactive intestinal peptide is released under transient proximal gastric distention in dogs, and that this response is not solely dependent upon the acid secretory effect of distention in this species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bloom S. R., Mitchell S. J., Greenberg G. R., Christofides N., Domschke W., Domschke S., Mitznegg P., Demling L. Release of VIP, secretin and motilin after duodenal acidification in man. Acta Hepatogastroenterol (Stuttg) 1978 Oct;25(5):365–368. [PubMed] [Google Scholar]
  2. Bryant M. G., Polak M. M., Modlin I., Bloom S. R., Albuquerque R. H., Pearse A. G. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet. 1976 May 8;1(7967):991–993. doi: 10.1016/s0140-6736(76)91863-8. [DOI] [PubMed] [Google Scholar]
  3. Domschke W., Lux G., Domschke S., Strunz U., Bloom S. R., Wünsch E. Effects of vasoactive intestinal peptide on resting and pentagastrin-stimulated lower esophageal sphincter pressure. Gastroenterology. 1978 Jul;75(1):9–12. [PubMed] [Google Scholar]
  4. Ebeid A. M., Murray P., Soeters P. B., Fischer J. E. Release of VIP by calcium stimulation. Am J Surg. 1977 Jan;133(1):140–144. doi: 10.1016/0002-9610(77)90208-2. [DOI] [PubMed] [Google Scholar]
  5. Ebeid A. M., Soeters P. B., Murray P., Fischer J. E. Release of vasoactive intestinal peptide (VIP) by intraluminal osmotic stimuli. J Surg Res. 1977 Jul;23(1):25–30. doi: 10.1016/0022-4804(77)90185-8. [DOI] [PubMed] [Google Scholar]
  6. Fahrenkrug J., Haglund U., Jodal M., Lundgren O., Olbe L., de Muckadell O. B. Nervous release of vasoactive intestinal polypeptide in the gastrointestinal tract of cats: possible physiological implications. J Physiol. 1978 Nov;284:291–305. doi: 10.1113/jphysiol.1978.sp012541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GROSSMAN M. I. Secretion of acid and pepsin in response to distention of vagally innervated fundic gland area in dogs. Gastroenterology. 1962 Jun;42:718–721. [PubMed] [Google Scholar]
  8. Guzman S., Chayvialle J. A., Banks W. A., Rayford P. L., Thompson J. C. Effect of vagal stimulation on pancreatic secretion and on blood levels of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide, and somatostatin. Surgery. 1979 Aug;86(2):329–336. [PubMed] [Google Scholar]
  9. Larsson L. I., Fahrenkrug J., Schaffalitzky De Muckadell O., Sundler F., Håkanson R., Rehfeld J. R. Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons. Proc Natl Acad Sci U S A. 1976 Sep;73(9):3197–3200. doi: 10.1073/pnas.73.9.3197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Larsson L. I., Fahrenkrug J., Schaffalitzky de Muckadell O. B. Vasoactive intestinal polypeptide occurs in nerves of the female genitourinary tract. Science. 1977 Sep 30;197(4311):1374–1375. doi: 10.1126/science.897673. [DOI] [PubMed] [Google Scholar]
  11. Modlin I. M., Bloom S. R., Mitchell S. Plasma vasoactive intestinal polypeptide (VIP) levels and intestinal ischaemia. Experientia. 1978 Apr 15;34(4):535–536. doi: 10.1007/BF01935976. [DOI] [PubMed] [Google Scholar]
  12. Mutt V., Said S. I. Structure of the porcine vasoactive intestinal octacosapeptide. The amino-acid sequence. Use of kallikrein in its determination. Eur J Biochem. 1974 Mar 1;42(2):581–589. doi: 10.1111/j.1432-1033.1974.tb03373.x. [DOI] [PubMed] [Google Scholar]
  13. Rattan S., Said S. I., Goyal R. K. Effect of vasoactive intestinal polypeptide. Proc Soc Exp Biol Med. 1977 May;155(1):40–43. [PubMed] [Google Scholar]
  14. Schaffalitzky de Muckadell O. B., Fahrenkrug J., Holst J. J., Lauritsen K. B. Release of vasoactive intestinal polypeptide (VIP) by intraduodenal stimuli. Scand J Gastroenterol. 1977;12(7):793–799. doi: 10.3109/00365527709181722. [DOI] [PubMed] [Google Scholar]
  15. Schedl H. P. Use of polyethylene glycol and phenol red as unabsorbed indicators for intestinal absorption studies in man. Gut. 1966 Apr;7(2):159–163. doi: 10.1136/gut.7.2.159. [DOI] [PMC free article] [PubMed] [Google Scholar]

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