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. 1980 Apr;21(4):287–292. doi: 10.1136/gut.21.4.287

Comparative absorption of vitamin D3 and 25-hydroxyvitamin D3 in intestinal disease.

M Davies, E B Mawer, E L Krawitt
PMCID: PMC1419609  PMID: 6253363

Abstract

The absorption of simultaneously administered equimolar doses of 14C vitamin D3 and 3H 25 hydroxyvitamin D3 (25-OH-D3) has been studied in controls and patients with a variety of gastrointestinal disorders. As assessed from peak radioactivity in the serum and from faecal excretion of radioactivity, malabsorption of both vitamin D3 and 25-OH-D3 occurred in patients with steatorrhoea. Malabsorption of vitamin D3 was greater than 25-OH-D3. The magnitude of malabsorption of these compounds was related to the severity of the steatorrhoea but was moderate enough to suggest that replacement therapy in patients with intestinal malabsorption should be accomplished with relatively small doses of vitamin D. The more potent vitamin D metabolites are probably unnecessary in this situation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avioli L. V., Lee S. W., McDonald J. E., Lund J., DeLuca H. F. Metabolism of vitamin D3-3H in human subjects: distribution in blood, bile, feces, and urine. J Clin Invest. 1967 Jun;46(6):983–992. doi: 10.1172/JCI105605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Compston J. E., Creamer B. Plasma levels and intestinal absorption of 25-hydroxyvitamin D in patients with small bowel resection. Gut. 1977 Mar;18(3):171–175. doi: 10.1136/gut.18.3.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Compston J. E., Horton L. W., Tighe J. R. Treatment of osteomalacia with oral 1-alpha-hydroxyvitamin D3 in a patient with malabsorption. Br Med J. 1977 Sep 3;2(6087):612–612. doi: 10.1136/bmj.2.6087.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Haddad J. G., Chyu K. J. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab. 1971 Dec;33(6):992–995. doi: 10.1210/jcem-33-6-992. [DOI] [PubMed] [Google Scholar]
  5. Krawitt E. L., Grundman M. J., Mawer E. B. Absorption, hydroxylation, and excretion of vitamin D3 in primary biliary cirrhosis. Lancet. 1977 Dec 17;2(8051):1246–1249. doi: 10.1016/s0140-6736(77)92660-5. [DOI] [PubMed] [Google Scholar]
  6. Mawer E. B., Schaefer K., Lumb G. A., Stanbury S. W. The metabolism of isotopically labelled vitamin D3 in man: the influence of the state of vitamin D nutrition. Clin Sci. 1971 Jan;40(1):39–53. doi: 10.1042/cs0400039. [DOI] [PubMed] [Google Scholar]
  7. Poskitt E. M., Cole T. J., Lawson D. E. Diet, sunlight, and 25-hydroxy vitamin D in healthy children and adults. Br Med J. 1979 Jan 27;1(6158):221–223. doi: 10.1136/bmj.1.6158.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Stamp T. C. Intestinal absorption of 25-hydroxycholecalciferol. Lancet. 1974 Jul 20;2(7873):121–123. doi: 10.1016/s0140-6736(74)91553-0. [DOI] [PubMed] [Google Scholar]
  9. Thompson G. R., Lewis B., Booth C. C. Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption. J Clin Invest. 1966 Jan;45(1):94–102. doi: 10.1172/JCI105327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Thompson G. R., Lewis B., Booth C. C. Vitamin-D absorption after partial gastrectomy. Lancet. 1966 Feb 26;1(7435):457–458. doi: 10.1016/s0140-6736(66)91458-9. [DOI] [PubMed] [Google Scholar]

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