Skip to main content
PMC home page
Gut logoLink to Gut
. 1982 Jun;23(6):475–480. doi: 10.1136/gut.23.6.475

Serum and intestinal secretory IgA in alcoholic cirrhosis of the liver.

G Pelletier, M J Briantais, C Buffet, J Pillot, J P Etienne
PMCID: PMC1419709  PMID: 7076021

Abstract

Serum and intestinal secretory IgA (sIgA) were investigated in control subjects and patients with alcoholic cirrhosis of the liver. Intestinal secretions were sampled by intraluminal perfusion with a balloon catheter. Monomeric IgA and sIgA were assayed by reversed radial immunodiffusion and nephelometry after separation by Ultrogel column filtration. High levels of serum sIgA were found only in patients with severe cirrhosis accompanied by jaundice. The intestinal rate of secretion of sIgA measured in these patients was significantly lower than that observed in either controls or the patients with compensated cirrhosis. Such an intestinal sIgA deficiency, which could be explained either by a fall in small intestinal immunocyte synthesis or by a defect in the transenterocyte transport system, could be partially responsible for the high incidence of intestinal infection observed in severe cirrhosis.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. André F., André C. Participation de l'immunoglobuline A monomérique et dimérique à l'hypergammaglobulinémie de la cirrhose éthylique. Biol Gastroenterol (Paris) 1976 Apr-May;9(2):147–150. [PubMed] [Google Scholar]
  2. Brandtzaeg P., Baklien K. Characterization of the IgA immunocyte population and its product in a patient with excessive intestinal formation of IgA. Clin Exp Immunol. 1977 Oct;30(1):77–88. [PMC free article] [PubMed] [Google Scholar]
  3. Brandtzaeg P., Baklien K. Intestinal secretion of IgA and IgM: a hypothetical model. Ciba Found Symp. 1977 Apr 26;(46):77–113. doi: 10.1002/9780470720288.ch5. [DOI] [PubMed] [Google Scholar]
  4. Brandtzaeg P. Human secretory immunoglobulins. V. Occurrence of secretory piece in human serum. J Immunol. 1971 Feb;106(2):318–323. [PubMed] [Google Scholar]
  5. Brandtzaeg P. Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells. J Immunol. 1974 Apr;112(4):1553–1559. [PubMed] [Google Scholar]
  6. Brandtzaeg P. Polymeric IgA is complexed with secretory component (SC) on the surface of human intestinal epithelial cells. Scand J Immunol. 1978;8(1):39–52. doi: 10.1111/j.1365-3083.1978.tb00494.x. [DOI] [PubMed] [Google Scholar]
  7. Brown W. R., Isobe K., Nakane P. K., Pacini B. Studies on translocation of immunoglobulins across intestinal epithelium. IV. Evidence for binding of IgA and IgM to secretory component in intestinal epithelium. Gastroenterology. 1977 Dec;73(6):1333–1339. [PubMed] [Google Scholar]
  8. Bull D. M., Bienenstock J., Tomasi T. B., Jr Studies on human intestinal immunoglobulin A. Gastroenterology. 1971 Mar;60(3):370–380. [PubMed] [Google Scholar]
  9. Cornet A., Hartmann L., Courtois J. E., Dubrisay J., Demelier J. F., Barbier J. P., Renault P., Carnot F., Debetz J., Dadoune J. P. Cirrhose du doie et intestin grêle. Confrontations cliniques, biologiques, histologiques, immunologiques et bactériologiques. Sem Hop. 1973 May 14;49(23):1639–1648. [PubMed] [Google Scholar]
  10. Davis P. J., Porter P. A mechanism for secretory IgA-mediated inhibition of the cell penetration and intracellular development of Eimeria tenella. Immunology. 1979 Mar;36(3):471–477. [PMC free article] [PubMed] [Google Scholar]
  11. Fisher M. M., Nagy B., Bazin H., Underdown B. J. Biliary transport of IgA: role of secretory component. Proc Natl Acad Sci U S A. 1979 Apr;76(4):2008–2012. doi: 10.1073/pnas.76.4.2008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Iscaki S., Geneste C., d'Azambuja S., Pillot J. Human secretory component. II. Easy detection of abnormal amounts of combined secretory component in human sera. J Immunol Methods. 1979;28(3-4):331–339. doi: 10.1016/0022-1759(79)90198-4. [DOI] [PubMed] [Google Scholar]
  13. Lemaître-Coelho I., Jackson G. D., Vaerman J. P. High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction. J Exp Med. 1978 Mar 1;147(3):934–939. doi: 10.1084/jem.147.3.934. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Modigliani R., Rambaud J. C., Bernier J. J. The method of intraluminal perfusion of the human small intestine. I. Principle and technique. Digestion. 1973;9(2):176–192. doi: 10.1159/000197443. [DOI] [PubMed] [Google Scholar]
  15. Nagura H., Smith P. D., Nakane P. K., Brown W. R. IGA in human bile and liver. J Immunol. 1981 Feb;126(2):587–595. [PubMed] [Google Scholar]
  16. Samson R. R., McClelland D. B., Shearman D. J. Studies on the quantitation of immunoglobulin in human intestinal secretions. Gut. 1973 Aug;14(8):616–626. doi: 10.1136/gut.14.8.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thomasi T. B., Jr Secretory immunoglobulins. N Engl J Med. 1972 Sep 7;287(10):500–506. doi: 10.1056/NEJM197209072871008. [DOI] [PubMed] [Google Scholar]
  18. Thompson R. A., Asquith P., Cooke W. T. Secretory IgA in the serum. Lancet. 1969 Sep 6;2(7619):517–519. doi: 10.1016/s0140-6736(69)90217-7. [DOI] [PubMed] [Google Scholar]
  19. Thompson R. A., Carter R., Stokes R. P., Geddes A. M., Goodall J. A. Serum immunoglobulins, complement component levels and autoantibodies in liver disease. Clin Exp Immunol. 1973 Jul;14(3):335–346. [PMC free article] [PubMed] [Google Scholar]
  20. Waldman R. H., Mach J. P., Stella M. M., Rowe D. S. Secretory IgA in human serum. J Immunol. 1970 Jul;105(1):43–47. [PubMed] [Google Scholar]
  21. Walker W. A., Isselbacher K. J. Intestinal antibodies. N Engl J Med. 1977 Oct 6;297(14):767–773. doi: 10.1056/NEJM197710062971407. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES