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. 1982 Jun;23(6):536–540. doi: 10.1136/gut.23.6.536

Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins.

S J Konturek, T Brzozowski, I Piastucki, T Radecki
PMCID: PMC1419713  PMID: 7042485

Abstract

Paracetamol or sodium salicylate given intragastrically 30 minutes before the administration of absolute ethanol or acidified aspirin dose-dependently reduced the formation of mucosal lesions. The generation of gastric mucosal prostaglandin-like activity increased with ethanol and was completely suppressed by acidified aspirin. Paracetamol or sodium salicylate given alone increased the generation of mucosal prostaglandin-like material. Indomethacin, the prostaglandin synthesis inhibitor, suppressed this effect and inhibited the protective influence of paracetamol or sodium salicylate on the production of gastric lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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