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. 1982 Apr;23(4):285–291. doi: 10.1136/gut.23.4.285

Antral gastrin-producing G-cells and somatostatin-producing D-cells in different states of gastric acid secretion.

R Arnold, M V Hülst, C H Neuhof, H Schwarting, H D Becker, W Creutzfeldt
PMCID: PMC1419730  PMID: 6122629

Abstract

The number of G- and D-cells per area and the ratio of G/D-cells were investigated in biopsy specimens of the pyloric antrum from normochlorhydric subjects without peptic ulcer, from patients with duodenal ulcer, gastrinoma, pernicious anaemia, and after selective proximal vagotomy. Compared with normochlorhydric subjects antral G-cell density was significantly raised in pernicious anaemia, unchanged in duodenal ulcer, and diminished in gastrinoma patients. After vagotomy G-cell density was found to be raised if compared with patients with duodenal ulcer. D-cell density was significantly increased in gastrinoma patients, unchanged in duodenal ulcer, and diminished in pernicious anaemia and after vagotomy. The G/D-cell ratio was increased in pernicious anaemia and after vagotomy, unchanged in duodenal ulcer, and decreased in gastrinoma patients. It is concluded that the antral pH governs the ratio of G- and D-cells. Therefore, the G/D cell ratio increases in states of reduced acid secretion and decreases in massive hyperchlorhydria. Hypergastrinaemia as such does not affect the G/D-cell ratio.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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