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. 1982 Oct;23(10):814–818. doi: 10.1136/gut.23.10.814

What does the antimitochondrial antibody mean?

D R Triger, C A Charlton, A M Ward
PMCID: PMC1419821  PMID: 7117900

Abstract

In a prospective survey positive antimitochondrial antibodies have been detected in 69/4200 (1.64%) of all sera submitted to a routine immunology laboratory. Of the 69, only nine patients had uniquivocal primary biliary cirrhosis, six others had chronic active hepatitis, 10 had abnormal liver function tests without evidence of primary biliary cirrhosis, while the remaining 44 had no clinical or biochemical evidence of liver disease. Outside the context of liver disease antimitochondrial antibodies were observed with similar frequency in patients with autoimmune disorders as in other conditions. It was not possible to distinguish primary biliary cirrhosis from patients without liver disease by antibody titre or by immunoglobulin subclass. The positive antimitochondrial antibody patients without liver disease were uniformly distributed throughout the city of Sheffield, in contrast with the marked clustering of cases of primary biliary cirrhosis. We conclude that, in the absence of clinical liver disease, the antimitochondrial antibody test alone (as detected by routine immunofluorescent techniques) does not appear to be a specific screening test for primary biliary cirrhosis. While we cannot exclude the possibility that the autoantibody indicates a predisposition to develop primary biliary cirrhosis, further prospective studies are needed to determine which patients will progress in this manner. The possibility that environmental factors may be implicated cannot be discounted.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Doniach D., Delhanty J., Lindqvist H. J., Catterall R. D. Mitochondrial and other tissue autoantibodies in patients with biological false positive reactions for syphilis. Clin Exp Immunol. 1970 Jun;6(6):871–884. [PMC free article] [PubMed] [Google Scholar]
  2. Epstein O., Jain S., Lee R. G., Cook D. G., Boss A. M., Scheuer P. J., Sherlock S. D-penicillamine treatment improves survival in primary biliary cirrhosis. Lancet. 1981 Jun 13;1(8233):1275–1277. doi: 10.1016/s0140-6736(81)92456-9. [DOI] [PubMed] [Google Scholar]
  3. Fulford K. W., Catterall R. D., Delhanty J. J., Doniach D., Kremer M. A collagen disorder of the nervous system presenting as multiple sclerosis. Brain. 1972;95(2):373–386. doi: 10.1093/brain/95.2.373. [DOI] [PubMed] [Google Scholar]
  4. Hislop W. S., Main G., Robertson A. J. Primary biliary cirrhosis: experience in a non-referral centre. Lancet. 1981 Jul 18;2(8238):144–144. doi: 10.1016/s0140-6736(81)90319-6. [DOI] [PubMed] [Google Scholar]
  5. Hodges J. R., Hall A. J., Wright R. Primary biliary cirrhosis and antimitochondrial antibodies. Lancet. 1981 Aug 15;2(8242):362–362. doi: 10.1016/s0140-6736(81)90671-1. [DOI] [PubMed] [Google Scholar]
  6. Homberg J. C., Rizzetto M., Doniach D. Ribosomal antibodies detected by immunofluorescence in systemic lupus erythematosus and other collagenoses. Clin Exp Immunol. 1974 Aug;17(4):617–628. [PMC free article] [PubMed] [Google Scholar]
  7. Ireton H. J., Muller H. K., McGiven A. R. Human antibody against rat gastric parietal cells and kidney brush border. Clin Exp Immunol. 1971 May;8(5):783–789. [PMC free article] [PubMed] [Google Scholar]
  8. James O., Macklon A. F., Watson A. J. Primary biliary cirrhosis--a revised clinical spectrum. Lancet. 1981 Jun 13;1(8233):1278–1281. doi: 10.1016/s0140-6736(81)92457-0. [DOI] [PubMed] [Google Scholar]
  9. Klatskin G., Kantor F. S. Mitochondrial antibody in primary biliary cirrhosis and other diseases. Ann Intern Med. 1972 Oct;77(4):533–541. doi: 10.7326/0003-4819-77-4-533. [DOI] [PubMed] [Google Scholar]
  10. Munoz L. E., Thomas H. C., Scheuer P. J., Doniach D., Sherlock S. Is mitochondrial antibody diagnostic of primary biliary cirrhosis? Gut. 1981 Feb;22(2):136–140. doi: 10.1136/gut.22.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rizzetto M., Swana G., Doniach D. Microsomal antibodies in active chronic hepatitis and other disorders. Clin Exp Immunol. 1973 Nov;15(3):331–344. [PMC free article] [PubMed] [Google Scholar]
  12. Triger D. R. Primary biliary cirrhosis: an epidemiological study. Br Med J. 1980 Sep 20;281(6243):772–775. doi: 10.1136/bmj.281.6243.772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Walker J. G., Doniach D., Doniach I. Mitochondrial antibodies and subclinical liver disease. Q J Med. 1970 Jan;39(153):31–48. [PubMed] [Google Scholar]

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