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. 1980 Jul;21(7):614–618. doi: 10.1136/gut.21.7.614

Duodenal calcium outputs in health and pancreatic disease.

P T Regan, J R Malagelada, E P DiMagno
PMCID: PMC1419897  PMID: 7429325

Abstract

To investigate the relationship between the duodenal outputs of calcium and diseases of the pancreas, we measured calcium secretion into the duodenum (during saline perfusion and after stimulation with an intravenous infusion of cholecystokinin (CCK) or secretin) in healthy controls, patients with chronic alcoholic or idiopathic pancreatitis, and patients with pancreatic cancer. The effects of acute and chronic hypercalcaemia and previous cholecystectomy were also studied. Our results indicate a characteristic increase in duodenal calcium outputs in response to CCK in chronic pancreatitis which is unaffected by the level of serum calcium, aetiology of the pancreatitis, previous cholecystectomy, and the presence or absence of radiological pancreatic calcifications. Although unproven, indirect observations support a pancreatic source for the increased calcium secretion. As we measured the outputs of calcium into the duodenum, previously described increases in calcium concentration are not merely a reflection of reduced volume secretion in chronic pancreatitis. Duodenal calcium outputs were significantly reduced in patients with cancer of the pancreas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DiMagno E. P., Go V. L., Summerskill W. H. Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med. 1973 Apr 19;288(16):813–815. doi: 10.1056/NEJM197304192881603. [DOI] [PubMed] [Google Scholar]
  2. DiMagno E. P., Malagelada J. R., Go V. L. The relationships between pancreatic ductal obstruction and pancreatic secretion in man. Mayo Clin Proc. 1979 Mar;54(3):157–162. [PubMed] [Google Scholar]
  3. DiMagno E. P., Malagelada J. R., Taylor W. F., Go V. L. A prospective comparison of current diagnostic tests for pancreatic cancer. N Engl J Med. 1977 Oct 6;297(14):737–742. doi: 10.1056/NEJM197710062971401. [DOI] [PubMed] [Google Scholar]
  4. GROSS J. B. Some recent developments pertaining to pancreatitis. Ann Intern Med. 1958 Oct;49(4):796–819. doi: 10.7326/0003-4819-49-4-796. [DOI] [PubMed] [Google Scholar]
  5. Go V. L., Hofmann A. F., Summerskill W. H. Simultaneous measurements of total pancreatic, biliary, and gastric outputs in man using a perfusion technique. Gastroenterology. 1970 Mar;58(3):321–328. [PubMed] [Google Scholar]
  6. Goebell H., Steffen C., Baltzer G., Bode C. Stimulation of pancreatic secretion of enzymes by acute hypercalcaemia in man. Eur J Clin Invest. 1973 Mar;3(2):98–104. doi: 10.1111/j.1365-2362.1973.tb00335.x. [DOI] [PubMed] [Google Scholar]
  7. HERSKOVIC T., WAKIM K. G., BARTHOLOMEW L. G., CAIN J. C., JONES J. D. RELATIONSHIP OF CALCIUM IN THE SERUM TO THAT IN THE PANCREATIC SECRETION IN NORMAL AND HYPERCALCEMIC STATES. Surgery. 1965 Sep;58:530–534. [PubMed] [Google Scholar]
  8. Hansky J. Calcium content of duodenal juice. Am J Dig Dis. 1967 Jul;12(7):725–733. doi: 10.1007/BF02238282. [DOI] [PubMed] [Google Scholar]
  9. KURLANDER D. J., RASKIN H. F., KIRSNER J. B. Coexistence of pancreatitis and hyperparathyroidism. Use of the secretin test in evaluation of pancreatic function before and after excision of a parathyroid adenoma. Ann Intern Med. 1963 Jun;58:1013–1016. doi: 10.7326/0003-4819-58-6-1013. [DOI] [PubMed] [Google Scholar]
  10. Kawanishi H., Sell J. E., Pollard H. M. Combined endoscopic pancreatic fluid collection and retrograde pancreatography in the diagnosis of pancreatic cancer and chronic pancreatitis. Gastrointest Endosc. 1975 Nov;22(2):82–85. doi: 10.1016/s0016-5107(75)73707-0. [DOI] [PubMed] [Google Scholar]
  11. Malagelada J. R., Go V. L., Summerskill W. H. Differing sensitivities of gallbladder and pancreas to cholecystokinin-pancreozymin (CCK-PZ) in man. Gastroenterology. 1973 May;64(5):950–954. [PubMed] [Google Scholar]
  12. Malagelada J. R., Holtermuller K. H., Sizemore G. W., Go V. L. The influence of hypercalcemia on basal and cholecystokinin-stimulated pancreatic, gallbladder, and gastric functions in man. Gastroenterology. 1976 Sep;71(3):405–408. [PubMed] [Google Scholar]
  13. Malagelada J. R., Longstreth G. F., Summerskill W. H., Go V. L. Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterology. 1976 Feb;70(2):203–210. [PubMed] [Google Scholar]
  14. Nimmo J., Finlayson N. D., Smith A. F., Shearman D. J. The production of calcium and magnesium during pancreatic function tests in health and disease. Gut. 1970 Feb;11(2):163–166. doi: 10.1136/gut.11.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. OWENS J. L., Jr, HOWARD J. M. Pancreatic calcification: a late sequel in the natural history of chronic alcoholism and alcoholic pancreatitis. Ann Surg. 1958 Mar;147(3):326–338. doi: 10.1097/00000658-195803000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. STEIN E. A., HSIU J., FISCHER E. H. ALPHA-AMYLASES AS CALCIUM-METALLOENZYMES. I. PREPARATION OF CALCIUM-FREE APOAMYLASES BY CHELATION AND ELECTRODIALYSIS. Biochemistry. 1964 Jan;3:56–61. doi: 10.1021/bi00889a010. [DOI] [PubMed] [Google Scholar]
  17. Sarles H. Chronic calcifying pancreatitis--chronic alcoholic pancreatitis. Gastroenterology. 1974 Apr;66(4):604–616. [PubMed] [Google Scholar]
  18. Warwick R. R., Tothill P., Percy-Robb I. W., Shearman D. J. The calcium concentration in pancreatic secretion in chronic pancreatitis and carcinoma of the pancreas. Scand J Gastroenterol. 1973;8(4):301–305. [PubMed] [Google Scholar]

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