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. 1983 Jan;24(1):38–41. doi: 10.1136/gut.24.1.38

Association of primary sclerosing cholangitis with HLA-B8.

R W Chapman, Z Varghese, R Gaul, G Patel, N Kokinon, S Sherlock
PMCID: PMC1419910  PMID: 6600227

Abstract

The frequency of HLA antigens was studied in 25 patients with primary sclerosing cholangitis and compared with a control group of 562 kidney donors. Fourteen patients also had ulcerative colitis. A significant increase in the frequency of HLA-B8 (60%) was found in the primary sclerosing cholangitis patients compared with controls (25%) (p less than 0.001). HLA-B8 was found in eight patients with ulcerative colitis. The frequency of HLA-B12 was significantly decreased (8%) compared with controls (30%) (p less than 0.02). Piecemeal necrosis was observed on liver histology in 66% of HLA-B8 positive and 50% of HLA-B8 negative patients. Low titres of serum autoantibodies were frequently found in the primary sclerosing cholangitis group but did not correspond to the presence of HLA-B8. Raised serum concentrations of IgM and IgG were not related to HLA-B8. This study has shown that in patients with primary sclerosing cholangitis there exists a disease susceptibility gene closely associated with the B locus of the major histocompatibility complex which may be modified by other factors such as ulcerative colitis. Patients with ulcerative colitis and HLA-B8 may be particularly liable to develop primary sclerosing cholangitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asquith P., Mackintosh P., Stokes P. L., Holmes G. K., Cooke W. T. Histocompatibility antigens in patients with inflammatory-bowel disease. Lancet. 1974 Jan 26;1(7848):113–115. doi: 10.1016/s0140-6736(74)92342-3. [DOI] [PubMed] [Google Scholar]
  2. Bodmer W. F. The HLA system and disease. The Oliver Sharpey Lecture 1979. J R Coll Physicians Lond. 1980 Jan;14(1):43–50. [PMC free article] [PubMed] [Google Scholar]
  3. Chapman R. W., Arborgh B. A., Rhodes J. M., Summerfield J. A., Dick R., Scheuer P. J., Sherlock S. Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology. Gut. 1980 Oct;21(10):870–877. doi: 10.1136/gut.21.10.870. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eddleston A. L., Williams R. HLA and liver disease. Br Med Bull. 1978 Sep;34(3):295–300. doi: 10.1093/oxfordjournals.bmb.a071515. [DOI] [PubMed] [Google Scholar]
  5. Eddleston A. L., Williams R. Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis. Lancet. 1974 Dec 28;2(7896):1543–1545. doi: 10.1016/s0140-6736(74)90287-6. [DOI] [PubMed] [Google Scholar]
  6. Fee H. J., Gewirtz H., Schiller J., Longmire W. P., Jr Sclerosing cholangitis and primary biliary cirrhosis--a disease spectrum? Ann Surg. 1977 Nov;186(5):589–593. doi: 10.1097/00000658-197711000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Freudenberg J., Baumann H., Arnold W., Berger J., Büschenfelde K. H. HLA in different forms of chronic active hepatitis. A comparison between adult patients and children. Digestion. 1977;15(4):260–270. doi: 10.1159/000198011. [DOI] [PubMed] [Google Scholar]
  8. Galbraith R. M., Eddleston A. L., Williams R., Webster A. D., Pattison J., Doniach D., Kennedy L. A., Batchelor J. R. Enhanced antibody responses in active chronic hepatitis: relation to HLA-B8 and HLA-B12 and porto-systemic shunting. Lancet. 1976 May 1;1(7966):930–934. doi: 10.1016/s0140-6736(76)92712-4. [DOI] [PubMed] [Google Scholar]
  9. Gleeson M. H., Walker J. S., Wentzel J., Chapman J. A., Harris R. Human leucocyte antigens in Crohn's disease and ulcerative colitis. Gut. 1972 Jun;13(6):438–440. doi: 10.1136/gut.13.6.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hamlyn A. N., Adams D., Sherlock S. Primary or secondary sicca complex? Investigation in primary biliary cirrhosis by histocompatibility testing. Br Med J. 1980 Aug 9;281(6237):425–426. doi: 10.1136/bmj.281.6237.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mackay I. R., Morris P. J. Association of autoimmune active chronic hepatitis with HL-A1,8. Lancet. 1972 Oct 14;2(7781):793–795. doi: 10.1016/s0140-6736(72)92149-6. [DOI] [PubMed] [Google Scholar]
  12. Mackay I. R., Tait B. D. HLA associations with autoimmune-type chronic active hepatitis: identification of B8-DRw3 haplotype by family studies. Gastroenterology. 1980 Jul;79(1):95–98. [PubMed] [Google Scholar]
  13. Morgan M. Y., Ross M. G., Ng C. M., Adams D. M., Thomas H. C., Sherlock S. HLA-B8, immunoglobulins, and antibody responses in alcohol-related liver disease. J Clin Pathol. 1980 May;33(5):488–492. doi: 10.1136/jcp.33.5.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Page A. R., Sharp H. L., Greenberg L. J., Yunis E. J. Genetic analysis of patients with chronic active hepatitis. J Clin Invest. 1975 Sep;56(3):530–535. doi: 10.1172/JCI108121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Roseau E. La cholangéite sclérosante primitive. 1978 Aug 26-Sep 2Nouv Presse Med. 7(28):2465–2467. [PubMed] [Google Scholar]

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