Skip to main content
NCBI home page
Gut logoLink to Gut
. 1983 Apr;24(4):345–350. doi: 10.1136/gut.24.4.345

Pseudotumoral enterocolitis and massive eosinophilia.

P J Malè, F de Toledo, S Widgren, R de Peyer, S Berthoud
PMCID: PMC1419957  PMID: 6832630

Abstract

We report a seven year history of a 23 year old woman born in the Antilles, with pseudotumoral enterocolitis and massive eosinophilia. In 1973 she developed a haemorrhagic colitis with massive peripheral eosinophilia of up to 60000/mm3. Medical treatment, mainly corticosteroids, failed to control the disease. The patient temporarily improved after colectomy and remained in remission for two years. In 1978 the disease recurred in the rectum and small intestine with formation of tumour-like granulomata and massive infiltration by eosinophils, unresponsive to corticosteroids. Intestinal blood and protein loss continued until death seven years after onset. In spite of exhaustive investigation, no parasites, allergens, or other aetiological agents could be found. As only the gut was infiltrated, the hypereosinophilic syndrome could be excluded. The enterocolitis here described does not correspond to an eosinophilic gastroenteritis, nor to other known inflammatory bowel diseases and to our knowledge has not been reported previously.

Full text

PDF
345

Images in this article

347Fig. 2
on p.347
347Fig. 3
on p.347
348Fig. 4
on p.348
348Fig. 5
on p.348
348Fig. 6
on p.348
349Fig. 7
on p.349

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chusid M. J., Dale D. C., West B. C., Wolff S. M. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 1975 Jan;54(1):1–27. [PubMed] [Google Scholar]
  2. Farmer R. G., Hawk W. A., Turnbull R. B., Jr Clinical patterns in Crohn's disease: a statistical study of 615 cases. Gastroenterology. 1975 Apr;68(4 Pt 1):627–635. [PubMed] [Google Scholar]
  3. Fauci A. S., Haynes B., Katz P. The spectrum of vasculitis: clinical, pathologic, immunologic and therapeutic considerations. Ann Intern Med. 1978 Nov;89(5 Pt 1):660–676. doi: 10.7326/0003-4819-89-5-660. [DOI] [PubMed] [Google Scholar]
  4. Johnstone J. M., Morson B. C. Eosinophilic gastroenteritis. Histopathology. 1978 Sep;2(5):335–348. doi: 10.1111/j.1365-2559.1978.tb01726.x. [DOI] [PubMed] [Google Scholar]
  5. Johnstone J. M., Morson B. C. Inflammatory fibroid polyp of the gastrointestinal tract. Histopathology. 1978 Sep;2(5):349–361. doi: 10.1111/j.1365-2559.1978.tb01727.x. [DOI] [PubMed] [Google Scholar]
  6. Jones M. B., Voet R., Pagani J., Lotysch M., O'Connell T., Koretz R. L. Multifocal eosinophilic granuloma involving the common bile duct: histologic and cholangiographic findings. Gastroenterology. 1981 Feb;80(2):384–389. [PubMed] [Google Scholar]
  7. Katz A. J., Goldman H., Grand R. J. Gastric mucosal biopsy in eosinophilic (allergic) gastroenteritis. Gastroenterology. 1977 Oct;73(4 Pt 1):705–709. [PubMed] [Google Scholar]
  8. Klein N. C., Hargrove R. L., Sleisenger M. H., Jeffries G. H. Eosinophilic gastroenteritis. Medicine (Baltimore) 1970 Jul;49(4):299–319. doi: 10.1097/00005792-197007000-00003. [DOI] [PubMed] [Google Scholar]
  9. Lennard-Jones J. E., Lockhart-Mummery H. E., Morson B. C. Clinical and pathological differentiation of Crohn's disease and proctocolitis. Gastroenterology. 1968 Jun;54(6):1162–1170. [PubMed] [Google Scholar]
  10. Lewin K. J., Ranchod M., Dorfman R. F. Lymphomas of the gastrointestinal tract: a study of 117 cases presenting with gastrointestinal disease. Cancer. 1978 Aug;42(2):693–707. doi: 10.1002/1097-0142(197808)42:2<693::aid-cncr2820420241>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  11. Loehr W. J., Mujahed Z., Zahn F. D., Gray G. F., Thorbjarnarson B. Primary lymphoma of the gastrointestinal tract: a review of 100 cases. Ann Surg. 1969 Aug;170(2):232–238. doi: 10.1097/00000658-196908000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Manko M. A., Cooper J. H., Myers R. N. Disseminated hypereosinophilic disease. Am J Gastroenterol. 1972 Apr;57(4):318–325. [PubMed] [Google Scholar]
  13. Marsden P. D. Other nematodes. Clin Gastroenterol. 1978 Jan;7(1):219–229. [PubMed] [Google Scholar]
  14. Morera P. Life history and redescription of Angiostrongylus costaricensis Morera and Céspedes, 1971. Am J Trop Med Hyg. 1973 Sep;22(5):613–621. doi: 10.4269/ajtmh.1973.22.613. [DOI] [PubMed] [Google Scholar]
  15. Parrillo J. E., Borer J. S., Henry W. L., Wolff S. M., Fauci A. S. The cardiovascular manifestations of the hypereosinophilic syndrome. Prospective study of 26 patients, with review of the literature. Am J Med. 1979 Oct;67(4):572–582. doi: 10.1016/0002-9343(79)90227-4. [DOI] [PubMed] [Google Scholar]
  16. Perrot P. A., Berthoud S., Widgren S. Colite grave avec hyperéosinophilie. Schweiz Med Wochenschr. 1979 Jun 16;109(24):920–927. [PubMed] [Google Scholar]
  17. Schachter H., Kirsner J. B. Definitions of inflammatory bowel disease of unknown etiology. Gastroenterology. 1975 Mar;68(3):591–600. [PubMed] [Google Scholar]
  18. Tytgat G. N., Grijm R., Dekker W., Den Hartog N. A. Fata eosinophilic enteritis. Gastroenterology. 1976 Sep;71(3):479–483. [PubMed] [Google Scholar]
  19. URELES A. L., ALSCHIBAJA T., LODICO D., STABINS S. J. Idiopathic eosinophilic infiltration of the gastrointestinal tract, diffuse and circumscribed; a proposed classification and review of the literature, with two additional cases. Am J Med. 1961 Jun;30:899–909. doi: 10.1016/0002-9343(61)90178-4. [DOI] [PubMed] [Google Scholar]
  20. Wood N. L., Coltman C. A. Localized primary extranodal Hodgkin's disease. Ann Intern Med. 1973 Jan;78(1):113–118. doi: 10.7326/0003-4819-78-1-113. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES