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. 1981 Aug;22(8):628–632. doi: 10.1136/gut.22.8.628

Splenic atrophy in adult coeliac disease: is it reversible?

P N Trewby, P M Chipping, S J Palmer, P D Roberts, S M Lewis, J S Stewart
PMCID: PMC1420073  PMID: 7286779

Abstract

A study of splenic function in 28 patients with adult coeliac disease showed no significant correlation between the half life of heat-damaged red cells and either the duration of pre-treatment exposure to gluten or the length of time on a gluten free diet. A significant correlation was found between splenic size and duration of treatment; those patients who had been taking a gluten free diet for the longest time had the smallest spleens. Blood films from 11 of these 28 patients taken before treatment with a gluten free diet were compared with those taken between two and 15 years after the start of treatment. There was no tendency for the hyposplenic changes to regress. In the majority, the changes became more prominent despite strict adherence to the gluten free diet. These findings suggest that splenic atrophy in adult coeliac disease is not reversed by treatment with a gluten free diet and is unlikely to be related to the state of the jejunal mucosa or the duration of initial exposure to gluten.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bowring C. S., Glass H. I., Lewis S. M. Rate of clearance by the spleen of heat-damaged erythrocytes. J Clin Pathol. 1976 Sep;29(9):852–854. doi: 10.1136/jcp.29.9.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bullen A. W., Losowsky M. S. Consequences of impaired splenic function. Clin Sci (Lond) 1979 Aug;57(2):129–137. doi: 10.1042/cs0570129. [DOI] [PubMed] [Google Scholar]
  3. Ferguson A., Hutton M. M., Maxwell J. D., Murray D. Adult coeliac disease in hyposplenic patients. Lancet. 1970 Jan 24;1(7639):163–164. doi: 10.1016/s0140-6736(70)90405-8. [DOI] [PubMed] [Google Scholar]
  4. Jones J., Mollison P. L. A simple and efficient method of labelling red cells with 99mTc for determination of red cell volume. Br J Haematol. 1978 Jan;38(1):141–148. doi: 10.1111/j.1365-2141.1978.tb07116.x. [DOI] [PubMed] [Google Scholar]
  5. Marsh G. W., Stewart J. S. Splenic function in adult coeliac disease. Br J Haematol. 1970 Oct;19(4):445–457. doi: 10.1111/j.1365-2141.1970.tb06972.x. [DOI] [PubMed] [Google Scholar]
  6. McCarthy C. F., Fraser I. D., Evans K. T., Read A. E. Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut. 1966 Apr;7(2):140–148. doi: 10.1136/gut.7.2.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Nelson E. W., Ertan A., Brooks F. P., Cerda J. J. Thrombocytosis in patients with celiac sprue. Gastroenterology. 1976 Jun;70(6):1042–1044. [PubMed] [Google Scholar]
  8. Pettit J. E., Hoffbrand A. V., Seah P. P., Fry L. Splenic atrophy in dermatitis herpetiformis. Br Med J. 1972 May 20;2(5811):438–440. doi: 10.1136/bmj.2.5811.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pettit J. E. Spleen function. Clin Haematol. 1977 Oct;6(3):639–656. [PubMed] [Google Scholar]
  10. Ryan F. P., Smart R. C., Holdsworth C. D., Preston F. E. Hyposplenism in inflammatory bowel disease. Gut. 1978 Jan;19(1):50–55. doi: 10.1136/gut.19.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Smart R. C., Ryan F. P., Holdworth C. D., Preston F. E. Relationship between splenic size and splenic function. Gut. 1978 Jan;19(1):56–59. doi: 10.1136/gut.19.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stewart J. S. Adult coeliac disease. Postgrad Med J. 1968 Aug;44(514):632–641. doi: 10.1136/pgmj.44.514.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Szur L., Marsh G. W., Pettit J. E. Studies of splenic function by means of radioisotope labelled red cells. Br J Haematol. 1972 Sep;23(Suppl):183–199. doi: 10.1111/j.1365-2141.1972.tb03518.x. [DOI] [PubMed] [Google Scholar]

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