Skip to main content
NCBI home page
Gut logoLink to Gut
. 1983 Sep;24(9):803–806. doi: 10.1136/gut.24.9.803

Effect of secretin, pancreozymin OP-CCK, and glucagon on bile flow and bile lipid secretion in rats.

K W Romanski, W J Bochenek
PMCID: PMC1420096  PMID: 6309617

Abstract

Rats equipped with biliary, duodenal, and vena cava cannulae and supplemented with Na taurocholate received 4 hour infusions of gastrointestinal hormones. Boots secretin increased bile flow by 63% and bile acid, cholesterol, and phospholipid output by 75, 96, and 73% respectively. This stimulatory effect on bile flow and bile acid secretion was observed also in the four hour postinfusion period. Kabi secretin had practically no effect on bile secretion. Boots pancreozymin stimulated bile flow by 45% and to some extent also stimulated bile acid output. OP-CCK and glucagon stimulated mainly bile flow rate.

Full text

PDF
803

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTLETT G. R. Phosphorus assay in column chromatography. J Biol Chem. 1959 Mar;234(3):466–468. [PubMed] [Google Scholar]
  2. Boyer J. L. Canalicular bile formation in the isolated perfused rat liver. Am J Physiol. 1971 Oct;221(4):1156–1163. doi: 10.1152/ajplegacy.1971.221.4.1156. [DOI] [PubMed] [Google Scholar]
  3. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  4. Gordon E. M., Douglas M. C., Jablonski P., Owen J. A., Sali A., Watts J. M. Gastroduodenal hormones and bile-secretion studies in the isolated perfused pig liver. Surgery. 1972 Nov;72(5):708–721. [PubMed] [Google Scholar]
  5. Jones R. S., Brooks F. P. Role of pyloric antrum in choleresis after insulin and feeding. Am J Physiol. 1967 Dec;213(6):1406–1408. doi: 10.1152/ajplegacy.1967.213.6.1406. [DOI] [PubMed] [Google Scholar]
  6. Jones R. S., Geist R. E., Hall A. D. The choleretic effects of glucagon and secretin in the dog. Gastroenterology. 1971 Jan;60(1):64–68. [PubMed] [Google Scholar]
  7. Jones R. S., Grossman M. I. Choleretic effects of cholecystokinin, gastrin II, and caerulein in the dog. Am J Physiol. 1970 Oct;219(4):1014–1018. doi: 10.1152/ajplegacy.1970.219.4.1014. [DOI] [PubMed] [Google Scholar]
  8. Jones R. S., Meyers W. C. Regulation of hepatic biliary secretion. Annu Rev Physiol. 1979;41:67–82. doi: 10.1146/annurev.ph.41.030179.000435. [DOI] [PubMed] [Google Scholar]
  9. Klaassen C. D. Comparison of the choleretic properties of bile acids. Eur J Pharmacol. 1973 Sep;23(3):270–275. doi: 10.1016/0014-2999(73)90094-0. [DOI] [PubMed] [Google Scholar]
  10. Petersen H., Grossman M. I. Pancreatic exocrine secretion in anesthetized and conscious rats. Am J Physiol. 1977 Dec;233(6):E530–E536. doi: 10.1152/ajpendo.1977.233.6.E530. [DOI] [PubMed] [Google Scholar]
  11. Pissidis A. G., Bomback C. T., Merchant F., Nyhus L. M. Hormonal regulation of bile secretion: a study in the isolated, perfused liver. Surgery. 1969 Dec;66(6):1075–1084. [PubMed] [Google Scholar]
  12. Russell T. R., Searle G. L., Jones R. S. The choleretic mechanisms of sodium taurocholate, secretin, and glucagon. Surgery. 1975 Apr;77(4):498–504. [PubMed] [Google Scholar]
  13. Rutishauser S. C. Proceedings: An analysis of the reported choleretic effect of secretin in the rat. J Physiol. 1976 May;257(1):59P–59P. [PubMed] [Google Scholar]
  14. Shaw R. A., Jones R. S. The choleretic action of cholecystokinin and cholecystokinin octapeptide in dogs. Surgery. 1978 Nov;84(5):622–625. [PubMed] [Google Scholar]
  15. Thulin L. The choleretic effect of pure natural cholecystokinin in dogs. Acta Chir Scand. 1973;139(7):635–640. [PubMed] [Google Scholar]
  16. ZAK B. Simple rapid microtechnic for serum total cholesterol. Am J Clin Pathol. 1957 May;27(5):583–588. doi: 10.1093/ajcp/27.5_ts.583. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES