Abstract
A sensitivity to dietary cereal has been reported previously in niacin-deficient rats by measuring a change in the intestinal absorption of radioactively-labelled cellobiotol and mannitol. The possibility that other stimuli could produce this sensitivity, the range of cereals that could induce the permeability change and the nature of the toxic component in cereal have now all been investigated. Treatment with triparanol induces sensitivity in rats to wheat, rye, barley, oats, and maize but not to rice or soybean. These cereals caused a similar response in niacin-deficient rats. Mucosal damage produced by methotrexate or cetrimide, however, did not sensitise the intestinal mucosa to dietary cereals. Gluten, zein, and pepsin/trypsin digests of gluten all induced the permeability defect in triparanol-treated rats. It is concluded that although gross disruption of the mucosal structure may not sensitise rats to cereals, various causes of mucosal cell damage can produce a susceptibility to gluten toxicity that resembles gluten-sensitivity in man.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bloch R., Menge H., Martini G. A., Riecken E. O. Effect of gluten on glucose absorption from the small intestine in experimentally induced malabsorption in rats. Digestion. 1972;7(3):139–146. doi: 10.1159/000197268. [DOI] [PubMed] [Google Scholar]
- Cobden I., Rothwell J., Axon A. T. Passive permeability in experimental intestinal damage in rats. Clin Sci (Lond) 1981 Jan;60(1):115–118. doi: 10.1042/cs0600115. [DOI] [PubMed] [Google Scholar]
- FRAZER A. C., FLETCHER R. F., ROSS C. A., SHAW B., SAMMONS H. G., SCHNEIDER R. Gluten-induced enteropathy: the effect of partially digested gluten. Lancet. 1959 Sep 5;2(7097):252–255. doi: 10.1016/s0140-6736(59)92051-3. [DOI] [PubMed] [Google Scholar]
- MCPHERSON J. R., SUMMERSKILL W. H. An acute malabsorption syndrome with reversible mucosal atrophy. Gastroenterology. 1963 Jun;44:900–904. [PubMed] [Google Scholar]
- McPherson J. R., Shorter R. G. Intestinal lesions associated with triparanol. A clinical and experimental study. Am J Dig Dis. 1965 Dec;10(12):1024–1033. doi: 10.1007/BF02233376. [DOI] [PubMed] [Google Scholar]
- Nakashima Y., Sanada H., Utsuki Y., Kawada S. Effect of nicotinic acid on catecholamine synthesis in rat brain. J Nutr Sci Vitaminol (Tokyo) 1978;24(2):67–76. doi: 10.3177/jnsv.24.67. [DOI] [PubMed] [Google Scholar]
- Riecken E. O., Rosenbaum R., Bloch R., Menge H., Ritt E., Aslan M., Dölle W. Tierexperimentelle Untersuchungen zur Frage der Spezifität der Dünndarmschleimhautveränderungen bei der einheimischen Sprue. Klin Wochenschr. 1969 Feb 15;47(4):202–213. doi: 10.1007/BF01725677. [DOI] [PubMed] [Google Scholar]
- Sandhu J. S., Fraser D. R. Assessment of intestinal permeability in the experimental rat with [3H]cellobiotol and [14C]mannitol. Clin Sci (Lond) 1982 Sep;63(3):311–316. doi: 10.1042/cs0630311. [DOI] [PubMed] [Google Scholar]
- Sandhu J. S., Fraser D. R. The metabolic origin of trigonelline in the rat. Biochem J. 1981 Dec 15;200(3):495–500. doi: 10.1042/bj2000495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soulé J. C., Neale G., Peters T. J. Functional and biochemical evidence of damage to enterocytes induced by triparanol: role of lysosomes and the effect of gluten-free diet. Clin Sci Mol Med. 1976 Jul;51(1):19–25. doi: 10.1042/cs0510019. [DOI] [PubMed] [Google Scholar]