Skip to main content
Gut logoLink to Gut
. 1983 Oct;24(10):904–908. doi: 10.1136/gut.24.10.904

Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.

T Gledhill, O M Howard, M Buck, A Paul, R H Hunt
PMCID: PMC1420131  PMID: 6311692

Abstract

Twenty four hour intragastric acidity and nocturnal acid output have been measured over five separate 24 hour periods in each of 12 patients with duodenal ulcer receiving either placebo, cimetidine 400 mg bd, cimetidine 300 mg nocte, ranitidine 150 mg bd, or ranitidine 300 mg nocte. In these doses ranitidine was significantly more effective at decreasing intragastric acidity and nocturnal acid output than cimetidine. There was no significant difference between twice daily ranitidine and night time ranitidine or between twice daily cimetidine and night time cimetidine in the reduction of intragastric acidity. Nocturnal acid output was controlled significantly better with ranitidine at night, twice daily dosage of ranitidine, and cimetidine at night, than by the twice daily dosage of cimetidine. It is suggested that a single nocturnal dose of cimetidine or ranitidine should be evaluated in a clinical trial.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blackwood W. S., Maudgal D. P., Northfield T. C. Prevention by bedtime cimetidine of duodenal-ulcer relapse. Lancet. 1978 Mar 25;1(8065):626–627. doi: 10.1016/s0140-6736(78)91135-2. [DOI] [PubMed] [Google Scholar]
  2. Burland W. L., Gleadle R. I., Lee R. M., Rowley-Jones D., Groom G. V. Prolactin responses to cimetidine. Br J Clin Pharmacol. 1979 Jan;7(1):19–21. doi: 10.1111/j.1365-2125.1979.tb00891.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burland W. L., Hawkins B. W., Beresford J. Cimetidine treatment for the prevention of recurrence of duodenal ulcer: an international collaborative study. Postgrad Med J. 1980 Mar;56(653):173–176. doi: 10.1136/pgmj.56.653.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fitzpatrick W. J., Blackwood W. S., Northfield T. C. Bedtime cimetidine maintenance treatment: optimum dose and effect on subsequent natural history of duodenal ulcer. Gut. 1982 Mar;23(3):239–242. doi: 10.1136/gut.23.3.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Knigge U., Wollesen F., Dejgarrd A., Thuesen B., Christiansen P. M. Comparison between dose-responses of prolactin, thyroid stimulating hormone and growth hormone to two different histamine H-2 receptor antagonists in normal men. Clin Endocrinol (Oxf) 1981 Dec;15(6):585–592. doi: 10.1111/j.1365-2265.1981.tb00705.x. [DOI] [PubMed] [Google Scholar]
  6. Langman M. J., Henry D. A., Ogilvie A. Ranitidine and cimetidine for duodenal ulcer. Scand J Gastroenterol Suppl. 1981 Jun;69:115–117. [PubMed] [Google Scholar]
  7. Lombardo L. Reversible amenorrhoea after ranitidine treatment. Lancet. 1982 Jan 23;1(8265):224–224. doi: 10.1016/s0140-6736(82)90789-9. [DOI] [PubMed] [Google Scholar]
  8. Mohammed R., Mitchell K. G., Mackay C. The treatment of "cimetidine resistant" peptic ulcers by ranitidine hydrochloride: a new histamine H2-receptor antagonist. Curr Med Res Opin. 1981;7(8):523–525. doi: 10.1185/03007998109112368. [DOI] [PubMed] [Google Scholar]
  9. Pounder R. E., Williams J. G., Milton-Thompson G. J., Misiewicz J. J. Effect of cimetidine on 24-hour intragastric acidity in normal subjects. Gut. 1976 Feb;17(2):133–138. doi: 10.1136/gut.17.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Walt R. P., Male P. J., Rawlings J., Hunt R. H., Milton-Thompson G. J., Misiewicz J. J. Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer. Gut. 1981 Jan;22(1):49–54. doi: 10.1136/gut.22.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Walt R. P., Trotman I. F., Frost R., Golding P. L., Shepherd T. H., Rawlings J., Hunt R. H., Colin-Jones D., Milton-Thompson G. J., Misiewicz J. J. Comparison of twice-daily ranitidine with standard cimetidine treatment of duodenal ulcer. Gut. 1981 Apr;22(4):319–322. doi: 10.1136/gut.22.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES