Skip to main content
PMC home page
Gut logoLink to Gut
. 1983 Oct;24(10):921–924. doi: 10.1136/gut.24.10.921

Treatment of reflux oesophagitis with ranitidine.

I C Wesdorp, W Dekker, E C Klinkenberg-Knol
PMCID: PMC1420136  PMID: 6311693

Abstract

The efficacy of ranitidine was evaluated using a two-staged trial in patients with endoscopically moderate or severe reflux oesophagitis. The results of a six week double blind placebo controlled trial (stage I) in 36 patients shows that ranitidine (150 mg bd) is superior to placebo in the acute treatment with significant symptomatic improvement concerning heartburn and regurgitation, and in healing or improvement of endoscopic lesions. Prolonged treatment with ranitidine for another six weeks (stage II) proved to be effective in more resistant cases. No clinical side effects or significant biochemical changes were noted during this trial.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aadland E., Berstad A. Effect of cimetidine on pentagastrin-stimulated gastric acid and pepsin secretion before and after 6 weeks of cimetidine treatment. Scand J Gastroenterol. 1978;13(2):193–197. doi: 10.3109/00365527809181747. [DOI] [PubMed] [Google Scholar]
  2. Behar J., Brand D. L., Brown F. C., Castell D. O., Cohen S., Crossley R. J., Pope C. E., 2nd, Winans C. S. Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. Gastroenterology. 1978 Feb;74(2 Pt 2):441–448. [PubMed] [Google Scholar]
  3. Brown P. Cimetidine in the treatment of reflux oesophagitis. Med J Aust. 1979 Jul 28;2(2):96–97. doi: 10.5694/j.1326-5377.1979.tb112743.x. [DOI] [PubMed] [Google Scholar]
  4. Dammann H. G., Kather H., Augustin H. J., Simon B. Untersuchung über die Wirkungsdauer von Ranitidin. Dtsch Med Wochenschr. 1980 Apr 25;105(17):603–605. doi: 10.1055/s-2008-1070714. [DOI] [PubMed] [Google Scholar]
  5. Denis P., Galmiche J. P., Ducrotte P., Colin R., Pasquis P., Lefrancois R. Effect of ranitidine on resting pressure and pentagastrin response of human lower esophageal sphincter. Dig Dis Sci. 1981 Nov;26(11):999–1002. doi: 10.1007/BF01314762. [DOI] [PubMed] [Google Scholar]
  6. Konturek S. J., Obtulowicz W., Kwiecien N., Sito E., Mikos E., Oleksy J. Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients. Gut. 1980 Mar;21(3):181–186. doi: 10.1136/gut.21.3.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lepsien G., Sonnenberg A., Berges W., Weber K. B., Wienbeck M., Siewert J. R., Blum A. L. Die Behandlung der Refluxösophagitis mit Cimetidin. Dtsch Med Wochenschr. 1979 Jun 22;104(25):901–906. doi: 10.1055/s-0028-1104011. [DOI] [PubMed] [Google Scholar]
  8. Longstreth G. F., Go V. L., Malagelada J. R. Postprandial gastric, pancreatic, and biliary response to histamine H2-receptor antagonists active duodenal ulcer. Gastroenterology. 1977 Jan;72(1):9–13. [PubMed] [Google Scholar]
  9. Richardson C. T. Effect of H2-receptor antagonists on gastric acid secretion and serum gastrin concentration: a review. Gastroenterology. 1978 Feb;74(2 Pt 2):366–370. [PubMed] [Google Scholar]
  10. Wesdorp E., Bartelsman J., Pape K., Dekker W., Tytgat G. N. Oral cimetidine in reflux esophagitis: a double blind controlled trial. Gastroenterology. 1978 May;74(5 Pt 1):821–824. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES