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. 1983 Feb;24(2):154–157. doi: 10.1136/gut.24.2.154

Gastro-oesophageal function in normal subjects after oral administration of ranitidine.

L Wallin, T Madsen, S Boesby
PMCID: PMC1420169  PMID: 6133814

Abstract

The aim of the study was to investigate gastro-oesophageal function in normal subjects after oral administration of 150 mg ranitidine as a single dose. The study was designed as a double blind crossover investigation. Ten healthy men, aged 26-49 years (median 29 years) joined the study. A series of oesophageal function tests were performed, starting 90 minutes after oral intake of ranitidine or placebo. Gastro-oesophageal sphincter pressure was measured using a perfused catheter system and a continuous pull-through technique. No changes in sphincter pressure could be demonstrated. Peristaltic amplitude in the body of the oesophagus as well as the duration and velocity of the peristalsis were measured after wet swallows (bolus 5 ml of water). We found no changes in these variables. Intragastric pH was measured and was higher after ranitidine than after placebo (p less than 0.005). Plasma ranitidine concentration did not correlate with intragastric pH. No effect of ranitidine could be demonstrated on the results of a standard acid clearing test. It is concluded that ranitidine, given orally in sufficient doses to suppress gastric acid secretion, does not influence gastro-oesophageal sphincter pressure or peristaltic activity in the oesophagus of normal subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bailey R. J., Sullivan S. N., Macdougall B. R., Williams R. Effect of cimetidine on lower oesophageal sphincter. Br Med J. 1976 Sep 18;2(6037):678–678. doi: 10.1136/bmj.2.6037.678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boesby S. Effect of changes in the intragastric milieu on competence of the gastro-oesophageal region. A study in normal subjects. Scand J Gastroenterol. 1977;12(2):215–220. [PubMed] [Google Scholar]
  3. Boesby S. Gastro-oesophageal sphincter pressure, motility and acid clearing. A study of hiatus hernia patients and normal subjects and of the effect of a modified belsey MK IV repair on the results of the manometric and acid-clearing tests. Scand J Gastroenterol. 1977;12(4):407–416. doi: 10.3109/00365527709181681. [DOI] [PubMed] [Google Scholar]
  4. Castell D. O., Harris L. D. Hormonal control of gastroesophageal-sphincter strength. N Engl J Med. 1970 Apr 16;282(16):886–889. doi: 10.1056/NEJM197004162821602. [DOI] [PubMed] [Google Scholar]
  5. Denis P., Galmiche J. P., Ducrotte P., Colin R., Pasquis P., Lefrancois R. Effect of ranitidine on resting pressure and pentagastrin response of human lower esophageal sphincter. Dig Dis Sci. 1981 Nov;26(11):999–1002. doi: 10.1007/BF01314762. [DOI] [PubMed] [Google Scholar]
  6. Domschke W., Lux G., Domschke S. Furan H2-antagonist ranitidine inhibits pentagastrin-stimulated gastric secretion stronger than cimetidine. Gastroenterology. 1980 Dec;79(6):1267–1271. [PubMed] [Google Scholar]
  7. Kett K., Aadland E., Berstad A. Inhibition of gastric secretion in man with a new H2-receptor antagonist, ranitidine. Scand J Gastroenterol. 1980;15(2):249–251. doi: 10.3109/00365528009181464. [DOI] [PubMed] [Google Scholar]
  8. Kravitz J. J., Snape W. J., Jr, Cohen S. Effect of histamine and histamine antagonists on human lower esophageal sphincter function. Gastroenterology. 1978 Feb;74(2 Pt 2):435–440. [PubMed] [Google Scholar]
  9. Myren J., Gjone E. A pioneer in Norwegian gastroenterology has died (Lars S Semb). Scand J Gastroenterol. 1980;15(8):919–919. [PubMed] [Google Scholar]
  10. Osborne D. H., Lennon J., Henderson M., Lidgard G., Creel R., Carter D. C. Effect of cimetidine on the human lower oesophageal sphincter. Gut. 1977 Feb;18(2):99–104. doi: 10.1136/gut.18.2.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sewing K. F., Billian A., Malchow H. Comparative study with ranitidine and cimetidine on gastric secretion in normal volunteers. Gut. 1980 Sep;21(9):750–752. doi: 10.1136/gut.21.9.750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wallin L. The influence of cimetidine on the acid gastro-oesophageal reflux in duodenal ulcer patients. Scand J Gastroenterol. 1980;15(2):157–163. doi: 10.3109/00365528009181448. [DOI] [PubMed] [Google Scholar]

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