Skip to main content
Gut logoLink to Gut
. 1980 Mar;21(3):249–262. doi: 10.1136/gut.21.3.249

Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.

A Allen, A Garner
PMCID: PMC1420360  PMID: 6995243

Full text

PDF
249

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen A., Pain R. H., Robson T. R. Model for the structure of the gastric mucous gel. Nature. 1976 Nov 4;264(5581):88–89. doi: 10.1038/264088a0. [DOI] [PubMed] [Google Scholar]
  2. Allen A., Snary D. The structure and function of gastric mucus. Gut. 1972 Aug;13(8):666–672. doi: 10.1136/gut.13.8.666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Allen A. Structure of gastrointestinal mucus glycoproteins and the viscous and gel-forming properties of mucus. Br Med Bull. 1978 Jan;34(1):28–33. [PubMed] [Google Scholar]
  4. Altamirano M., Requena, Pérez T. C. Interstitial fluid pressure and alkaline gastric secretion. Am J Physiol. 1975 Nov;229(5):1421–1426. doi: 10.1152/ajplegacy.1975.229.5.1421. [DOI] [PubMed] [Google Scholar]
  5. Andre C., Bruhiere J., Vagne M., Lambert R. Bicarbonate secretion in the human stomach. Acta Hepatogastroenterol (Stuttg) 1973 Jan-Feb;20(1):62–69. [PubMed] [Google Scholar]
  6. Bolton J. P., Cohen M. M. Stimulation of non-parietal cell secretion in canine Heidenhain pouches by 16,16-dimethyl prostaglandin E2. Digestion. 1978 Jul-Aug;17(4):291–299. doi: 10.1159/000198122. [DOI] [PubMed] [Google Scholar]
  7. Bolton J. P., Palmer D., Cohen M. M. Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins. Am J Dig Dis. 1978 Apr;23(4):359–364. doi: 10.1007/BF01072421. [DOI] [PubMed] [Google Scholar]
  8. Bugajski J., Code C. F., Schlegel J. F. Sodium-hydrogen ion exchange across canine resting gastric mucosa. Am J Physiol. 1972 Apr;222(4):858–863. doi: 10.1152/ajplegacy.1972.222.4.858. [DOI] [PubMed] [Google Scholar]
  9. Cheung L. Y., Newton W. T. Cyclic guanosine monophosphate response to acetylcholine stimulation of gastric alkaline secretion. Surgery. 1979 Jul;86(1):156–162. [PubMed] [Google Scholar]
  10. DAVENPORT H. W., CHAVRE V. J. Conditions affecting acid secretion by mouse stomachs in vitro. Gastroenterology. 1950 Jul;15(3):467–480. [PubMed] [Google Scholar]
  11. DAVENPORT H. W., WARNER H. A., CODE C. F. FUNCTIONAL SIGNIFICANCE OF GASTRIC MUCOSAL BARRIER TO SODIUM. Gastroenterology. 1964 Aug;47:142–152. [PubMed] [Google Scholar]
  12. Davenport H. W. Salicylate damage to the gastric mucosal barrier. N Engl J Med. 1967 Jun 8;276(23):1307–1312. doi: 10.1056/NEJM196706082762308. [DOI] [PubMed] [Google Scholar]
  13. Domschke W., Domschke S., Hornig D., Demling L. Prostaglandin-stimulated gastric mucus secretion in man. Acta Hepatogastroenterol (Stuttg) 1978 Aug;25(4):292–294. [PubMed] [Google Scholar]
  14. Dunstone J. R., Morgan W. T. Further observations on the glycoproteins in human ovarian cyst fluids. Biochim Biophys Acta. 1965 Nov 1;101(3):300–314. doi: 10.1016/0926-6534(65)90009-6. [DOI] [PubMed] [Google Scholar]
  15. FLOREY H. Mucin and the protection of the body. Proc R Soc Lond B Biol Sci. 1955 Jan 27;143(911):147–158. doi: 10.1098/rspb.1955.0001. [DOI] [PubMed] [Google Scholar]
  16. Fisher R. B., Hunt J. N. The inorganic components of gastric secretion. J Physiol. 1950 Apr 15;111(1-2):138–149. doi: 10.1113/jphysiol.1950.sp004469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Flemström G., Sachs T. G. Ion transport by amphibian antrum in vitro. I. General characteristics. Am J Physiol. 1975 Apr;228(4):1188–1198. doi: 10.1152/ajplegacy.1975.228.4.1188. [DOI] [PubMed] [Google Scholar]
  18. Forstner J. F., Jabbal I., Forstner G. G. Goblet cell mucin of rat small intestine. Chemical and physical characterization. Can J Biochem. 1973 Aug;51(8):1154–1166. doi: 10.1139/o73-152. [DOI] [PubMed] [Google Scholar]
  19. Fromm D., Schwartz J. H. Ion transport across isolated antral mucosa of the rabbit. Am J Physiol. 1976 Dec;231(6):1783–1789. doi: 10.1152/ajplegacy.1976.231.6.1783. [DOI] [PubMed] [Google Scholar]
  20. Gardham J. R., Hobsley M. The electrolytes of alkaline human gastric juice. Clin Sci. 1970 Jul;39(1):77–87. doi: 10.1042/cs0390077. [DOI] [PubMed] [Google Scholar]
  21. Garner A. Assessment of gastric mucosal damage: comparative effects of aspirin and fenclofenac on the gastric mucosa of the guinea pig. Toxicol Appl Pharmacol. 1977 Dec;42(3):477–486. doi: 10.1016/s0041-008x(77)80032-x. [DOI] [PubMed] [Google Scholar]
  22. Garner A. Effects of acetylsalicylate on alkalinization, acid secretion and electrogenic properties in the isolated gastric mucosa. Acta Physiol Scand. 1977 Mar;99(3):281–291. doi: 10.1111/j.1748-1716.1977.tb10381.x. [DOI] [PubMed] [Google Scholar]
  23. Garner A., Flemström G. Gastric HCO3--secretion in the guinea pig. Am J Physiol. 1978 Jun;234(6):E535–E541. doi: 10.1152/ajpendo.1978.234.6.E535. [DOI] [PubMed] [Google Scholar]
  24. Garner A., Flemström G., Heylings J. R. Effects of antiinflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa. Gastroenterology. 1979 Sep;77(3):451–457. [PubMed] [Google Scholar]
  25. Garner A., Heylings J. R. Stimulation of alkaline secretion in amphibian-isolated gastric mucosa by 16,16-dimethyl PGE2 and PGF2 alpha. A proposed explanation for some of the cytoprotective actions of prostaglandins. Gastroenterology. 1979 Mar;76(3):497–503. [PubMed] [Google Scholar]
  26. Glass G. B., Slomiany B. L. Derangements of biosynthesis, production and secretion of mucus in gastrointestinal injury and disease. Adv Exp Med Biol. 1977;89:311–347. doi: 10.1007/978-1-4613-4172-7_23. [DOI] [PubMed] [Google Scholar]
  27. HEATLEY N. G. Mucosubstance as a barrier to diffusion. Gastroenterology. 1959 Sep;37:313–317. [PubMed] [Google Scholar]
  28. HOLLANDER F. The two-component mucous barrier; its activity in protecting the gastroduodenal mucosa against peptic ulceration. AMA Arch Intern Med. 1954 Jan;93(1):107–120. doi: 10.1001/archinte.1954.00240250117009. [DOI] [PubMed] [Google Scholar]
  29. Hart F. D. Indomethacin and gastric ulcer. Br Med J. 1965 Oct 23;2(5468):1000–1001. doi: 10.1136/bmj.2.5468.1000-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Kauffman G. L., Jr, Grossman M. I. Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates. Gastroenterology. 1978 Dec;75(6):1099–1102. [PubMed] [Google Scholar]
  31. Kelly D. G., Code C. F., Lechago J., Bugajski J., Schlegel J. F. Physiological and morphological characteristics of progressive disruption of the canine gastric mucosal barrier. Dig Dis Sci. 1979 Jun;24(6):424–441. doi: 10.1007/BF01299824. [DOI] [PubMed] [Google Scholar]
  32. Kent P. W., Allen A. The biosynthesis of intestinal mucins. The effect of salicylate on glycoprotein biosynthesis by sheep colonic and human gastric mucosal tissues in vitro. Biochem J. 1968 Feb;106(3):645–658. doi: 10.1042/bj1060645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Kim Y. S., Horowitz M. I. Solubilization and chemical and immunochemical characterization of sparingly soluble canine gastric mucin. Biochim Biophys Acta. 1971 Jun 29;236(3):686–701. doi: 10.1016/0005-2795(71)90254-6. [DOI] [PubMed] [Google Scholar]
  34. Kivilaakso E., Barzilai A., Schiessel R., Crass R., Silen W. Ulceration of isolated amphibian gastric mucosa. Gastroenterology. 1979 Jul;77(1):31–37. [PubMed] [Google Scholar]
  35. Kumar P. J., Ferguson A., Lancaster-Smith M., Clark M. L. Food antibodies in patients with dermatitis herpetiformis and adult coeliac disease - relationship to jejunal morphology. Scand J Gastroenterol. 1976;11(1):5–9. [PubMed] [Google Scholar]
  36. Lönnerholm G. Carbonic anhydrase in the intestinal tract of the guinea-pig. Acta Physiol Scand. 1977 Jan;99(1):53–61. doi: 10.1111/j.1748-1716.1977.tb10352.x. [DOI] [PubMed] [Google Scholar]
  37. MENGUY R., MASTERS Y. F. EFFECTS OF ASPIRIN ON GASTRIC MUCOUS SECRETION. Surg Gynecol Obstet. 1965 Jan;120:92–98. [PubMed] [Google Scholar]
  38. Makhlouf G. M., McManus J. P., Card W. I. A quantitative statement of the two-component hypothesis of gastric secretion. Gastroenterology. 1966 Aug;51(2):149–171. [PubMed] [Google Scholar]
  39. Mantle M., Allen A. A colorimetric assay for glycoproteins based on the periodic acid/Schiff stain [proceedings]. Biochem Soc Trans. 1978;6(3):607–609. doi: 10.1042/bst0060607. [DOI] [PubMed] [Google Scholar]
  40. Okosdinossian E. T., el-Munshid H. A. Composition of the alkaline component of human gastric juice: effect of swallowed saliva and duodeno-gastric reflux. Scand J Gastroenterol. 1977;12(8):945–950. doi: 10.3109/00365527709181354. [DOI] [PubMed] [Google Scholar]
  41. Parke D. V. Pharmacology of mucus. Br Med Bull. 1978 Jan;34(1):89–94. doi: 10.1093/oxfordjournals.bmb.a071465. [DOI] [PubMed] [Google Scholar]
  42. Robert A. Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins. Adv Prostaglandin Thromboxane Res. 1976;2:507–520. [PubMed] [Google Scholar]
  43. Scawen M., Allen A. The action of proteolytic enzymes on the glycoprotein from pig gastric mucus. Biochem J. 1977 May 1;163(2):363–368. doi: 10.1042/bj1630363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Schrager J., Oates M. D. Relation of human gastrointestinal mucus to disease states. Br Med Bull. 1978 Jan;34(1):79–82. doi: 10.1093/oxfordjournals.bmb.a071463. [DOI] [PubMed] [Google Scholar]
  45. Schrager J. The composition and some structural features of the principal gastric glycoprotein. Digestion. 1969;2(2):73–89. doi: 10.1159/000196926. [DOI] [PubMed] [Google Scholar]
  46. Slomiany B. L., Meyer K. Isolation and structural studies of sulfated glycoproteins of hog gastric mucosa. J Biol Chem. 1972 Aug 25;247(16):5062–5070. [PubMed] [Google Scholar]
  47. Snary D., Allen A., Pain R. H. Structural studies on gastric mucoproteins: lowering of molecular weight after reduction with 2-mercaptoethanol. Biochem Biophys Res Commun. 1970 Aug 24;40(4):844–851. doi: 10.1016/0006-291x(70)90980-0. [DOI] [PubMed] [Google Scholar]
  48. Snary D., Allen A. Studies on gastric mucoproteins. The isolation and characterization of the mucoprotein of the water-soluble mucus from pig cardiac gastric mucosa. Biochem J. 1971 Aug;123(5):845–853. doi: 10.1042/bj1230845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Spenney J. G. Physical chemical and technical limitations to intragastric titration. Gastroenterology. 1979 May;76(5 Pt 1):1025–1034. [PubMed] [Google Scholar]
  50. Starkey B. J., Snary D., Allen A. Characterization of gastric mucoproteins isolated by equilibrium density-gradient centrifugation in caesium chloride. Biochem J. 1974 Sep;141(3):633–639. doi: 10.1042/bj1410633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Steer H. W., Colin-Jones D. G. Mucosal changes in gastric ulceration and their response to carbenoxolone sodium. Gut. 1975 Aug;16(8):590–597. doi: 10.1136/gut.16.8.590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Sung C. P., Wiebelhaus V. D., Jenkins B. C., Adlercreutz P., Hirschowitz B. I., Sachs G. Heterogeneity of 3',5'-phosphodiesterase of gastric mucosa. Am J Physiol. 1972 Sep;223(3):648–650. doi: 10.1152/ajplegacy.1972.223.3.648. [DOI] [PubMed] [Google Scholar]
  53. Thjodleifsson B., Wormsley K. G. Back-diffusion--fact or fiction? Digestion. 1977;15(1):53–72. doi: 10.1159/000197983. [DOI] [PubMed] [Google Scholar]
  54. WERTHER J. L., HOLLANDER F., ALTAMIRANO M. EFFECT OF ACETAZOLAMIDE ON GASTRIC MUCOSA IN CANINE VIVO-VITRO PREPARATIONS. Am J Physiol. 1965 Jul;209:127–133. doi: 10.1152/ajplegacy.1965.209.1.127. [DOI] [PubMed] [Google Scholar]
  55. Watkins W. M. Blood-group substances. Science. 1966 Apr 8;152(3719):172–181. doi: 10.1126/science.152.3719.172. [DOI] [PubMed] [Google Scholar]
  56. Whittle B. J. Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins. Eur J Pharmacol. 1976 Dec;40(2):233–239. doi: 10.1016/0014-2999(76)90057-1. [DOI] [PubMed] [Google Scholar]
  57. Zalewsky C. A., Moody F. G. Mechanisms of mucus release in exposed canine gastric mucosa. Gastroenterology. 1979 Oct;77(4 Pt 1):719–729. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES