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. 1992 Jul;76(3):385–388.

Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.

J Marcinkiewicz 1, E Olszowska 1, S Olszowski 1, J M Zgliczynski 1
PMCID: PMC1421697  PMID: 1382040

Abstract

Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and affected mainly T-helper-cell activation. Since stimulated neutrophils chlorinate in vivo proteins, we propose that they take part in the induction phase of immune response by facilitation of antigen processing and/or presentation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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