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. 1993 Jan;78(1):1–6.

Infection with feline immunodeficiency virus is followed by the rapid expansion of a CD8+ lymphocyte subset.

B J Willett 1, M J Hosie 1, J J Callanan 1, J C Neil 1, O Jarrett 1
PMCID: PMC1421779  PMID: 8094707

Abstract

Lymphocyte subset analysis was performed on specific pathogen-free cats infected with feline immunodeficiency virus (FIV). As early as 4 weeks post-infection a sharp rise in lymphocytes expressing the feline CD8 marker (fCD8) occurred. No changes were observed in feline CD4+ (fCD4+) cell number throughout this period. The expanded subset displayed reduced expression of the fCD8 marker (fCD8low) compared to the control population (fCD8high). Dual-labelling revealed increased levels of major histocompatibility complex (MHC) class II antigens on the fCD8low subset compared to the fCD8high subset. The fCD8low population appeared to persist as it was detected in cats which had been infected for a period of 18 months and which displayed significantly reduced numbers of fCD4+ lymphocytes. The data suggest that infection with FIV induces rapid alterations in the lymphocyte profile of the cat characterized by the expansion of a fCD8+ lymphocyte subset. The persistence of this population throughout the course of infection suggests that the early events in FIV infection may be of importance in the pathogenesis of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackley C. D., Hoover E. A., Cooper M. D. Identification of a CD4 homologue in the cat. Tissue Antigens. 1990 Feb;35(2):92–98. doi: 10.1111/j.1399-0039.1990.tb01762.x. [DOI] [PubMed] [Google Scholar]
  2. Ackley C. D., Yamamoto J. K., Levy N., Pedersen N. C., Cooper M. D. Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus. J Virol. 1990 Nov;64(11):5652–5655. doi: 10.1128/jvi.64.11.5652-5655.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hosie M. J., Jarrett O. Serological responses of cats to feline immunodeficiency virus. AIDS. 1990 Mar;4(3):215–220. doi: 10.1097/00002030-199003000-00006. [DOI] [PubMed] [Google Scholar]
  4. Klotz F. W., Cooper M. D. A feline thymocyte antigen defined by a monoclonal antibody (FT2) identifies a subpopulation of non-helper cells capable of specific cytotoxicity. J Immunol. 1986 Apr 1;136(7):2510–2514. [PubMed] [Google Scholar]
  5. Kundu S. K., Merigan T. C. Inverse relationship of CD8+CD11+ suppressor T cells with human immunodeficiency virus (HIV)-specific cellular cytotoxicity and natural killer cell activity in HIV infection. Immunology. 1991 Dec;74(4):567–571. [PMC free article] [PubMed] [Google Scholar]
  6. Novotney C., English R. V., Housman J., Davidson M. G., Nasisse M. P., Jeng C. R., Davis W. C., Tompkins M. B. Lymphocyte population changes in cats naturally infected with feline immunodeficiency virus. AIDS. 1990 Dec;4(12):1213–1218. doi: 10.1097/00002030-199012000-00005. [DOI] [PubMed] [Google Scholar]
  7. Rideout B. A., Moore P. F., Pedersen N. C. Distribution of MHC class II antigens in feline tissues and peripheral blood. Tissue Antigens. 1990 Nov;36(5):221–227. doi: 10.1111/j.1399-0039.1990.tb01832.x. [DOI] [PubMed] [Google Scholar]
  8. Schnizlein-Bick C. T., Magier M. R., Jones R. B., Fife K. H., Katz B. P., Walker E. B. Differences among mononuclear cell subpopulations in HIV seropositive or seronegative homosexual and heterosexual men as determined by four-color flow cytometry. J Acquir Immune Defic Syndr. 1990;3(8):747–756. [PubMed] [Google Scholar]
  9. Stites D. P., Casavant C. H., McHugh T. M., Moss A. R., Beal S. L., Ziegler J. L., Saunders A. M., Warner N. L. Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence. Clin Immunol Immunopathol. 1986 Feb;38(2):161–177. doi: 10.1016/0090-1229(86)90135-2. [DOI] [PubMed] [Google Scholar]
  10. Torten M., Franchini M., Barlough J. E., George J. W., Mozes E., Lutz H., Pedersen N. C. Progressive immune dysfunction in cats experimentally infected with feline immunodeficiency virus. J Virol. 1991 May;65(5):2225–2230. doi: 10.1128/jvi.65.5.2225-2230.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Willett B. J., Hosie M. J., Dunsford T. H., Neil J. C., Jarrett O. Productive infection of T-helper lymphocytes with feline immunodeficiency virus is accompanied by reduced expression of CD4. AIDS. 1991 Dec;5(12):1469–1475. doi: 10.1097/00002030-199112000-00009. [DOI] [PubMed] [Google Scholar]

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