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. 1993 Jun;79(2):255–262.

Effects of CD8 depletion on retinal soluble antigen induced experimental autoimmune uveoretinitis.

V L Calder 1, Z S Zhao 1, Y Wang 1, K Barton 1, S L Lightman 1
PMCID: PMC1421879  PMID: 8102121

Abstract

During the later stages of soluble-antigen (sAg)-induced experimental autoimmune uveoretinitis (EAU), an increase in the relative number of CD8+ lymphocytes has been observed at the site of inflammation in the retina. It has been suggested that these late-appearing CD8+ cells might down-regulate this acute disease process. To determine the role of the CD8+ cells in EAU, Lewis rats were depleted of CD8+ cells prior to and during disease and the enucleated eyes examined histologically. The spleen cells from CD8-depleted rats were also examined for their ability to respond to concanavalin A (Con A) and to allogeneic targets as determined by mixed lymphocyte reaction (MLR) and cytotoxicity assays. The results suggest that depleting CD8+ cells had no effect on the course of disease and that CD8+ cells do not play a crucial role in the immunoregulation of EAU.

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Selected References

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