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. 1993 Jul;79(3):509–511.

Adhesion of CD16+ K cells to antibody-coated targets is mediated by CD2 and CD18 receptors.

J C Voltarelli 1, G Gjerset 1, C Anasetti 1
PMCID: PMC1421975  PMID: 8104886

Abstract

In order to investigate the function of CD2 and CD18 receptors in antibody-dependent cellular cytotoxicity (ADCC), Fab' fragments of the monoclonal antibodies 9.6 (anti-CD2) and 60.3 (anti-CD18) were preincubated with the human natural killer (NK) clone EB4.19 and tested for conjugate formation and cytotoxic function against the human B-cell line KMS and the mouse thymoma line SL-2. We concluded that: (1) the FcR CD16 does not participate in conjugate formation; (2) adhesion between target and effector cells mediated by CD2 and CD18 is a prerequisite for subsequent activation of the lytic programme through the CD16 receptor.

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Selected References

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