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. 1973 Jul;25(1):123–130.

The structural basis of cell-mediated immunological reactions of collagen

The species specificity of the cutaneous delayed hypersensitivity reaction

B C Adelmann, J Kirrane
PMCID: PMC1422839  PMID: 4579115

Abstract

Guinea-pigs were sensitized for delayed hypersensitivity skin reactions with native rat, rabbit, fish, or human collagen or with (L-Pro-Gly-L-Pro)n, mixed with Freund's complete adjuvant (FCA). Mammalian collagens were more immunogenic than fish collagen and the synthetic, collagen-like polymer. The terminal, non-helical portions of calf and rat collagen were not required for expression of species specific cell-mediated reactions of these collagens. Although the animals could readily distinguish between mammalian collagens on one hand and fish collagen and (L-Pro-Gly-L-Pro)n on the other, the discriminatory capacity was best expressed among each of the two groups of antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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