Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1973 Jul;25(1):91–101.

Granulocyte-macrophage precursor cell responses in mice of different strain, sex and age

T A McNeill, W A Fleming, Sheena F McClure, M Killen
PMCID: PMC1422843  PMID: 4723005

Abstract

Mice inoculated with Freund's complete adjuvant show an increase in the number of granulocyte-macrophage precursor cells (colony-forming cells) in haemopoietic tissues. This effect is most marked in spleen and reaches a maximum 7 days after inoculation.

The magnitude of the cellular response was measured in five mouse strains (C57B1, CBA, VSBS, TO and HR) and some significant differences were found, although no differences in the level of serum regulating factors were apparent. Colony-forming cell responses were weaker in young adult males than in females and were also weaker in mice at extremes of age.

It was suggested that differences in the magnitude of cellular responses could reflect differences in the responsiveness of target cells to the same stimulus and that broad parallels may exist between myelopoietic and immunological responsiveness.

Full text

PDF
91

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bradley T. R., Metcalf D. The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci. 1966 Jun;44(3):287–299. doi: 10.1038/icb.1966.28. [DOI] [PubMed] [Google Scholar]
  2. Bradley T. R., Sumner M. A. Stimulation of mouse bone marrow colony growth in vitro by conditioned medium. Aust J Exp Biol Med Sci. 1968 Oct;46(5):607–618. doi: 10.1038/icb.1968.167. [DOI] [PubMed] [Google Scholar]
  3. Briganti G., Covelli V., Silini G., Srivastava P. N. The distribution of erythropoietic bone marrow in the mouse. Acta Haematol. 1970;44(6):355–361. doi: 10.1159/000208704. [DOI] [PubMed] [Google Scholar]
  4. Cudkowicz G., Shearer G. M., Ito T. Cellular differentiation of the immune system of mice. VI. Strain differences in class differentiation and other properties of marrow cells. J Exp Med. 1970 Oct 1;132(4):623–635. doi: 10.1084/jem.132.4.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FRIEDMAN H. DISTRIBUTION OF ANTIBODY PLAQUE FORMING CELLS IN VARIOUS TISSUES OF SEVERAL STRAINS OF MICE INJECTED WITH SHEEP ERYTHROCYTES. Proc Soc Exp Biol Med. 1964 Nov;117:526–530. doi: 10.3181/00379727-117-29628. [DOI] [PubMed] [Google Scholar]
  6. Foster R., Jr, Metcalf D., Robinson W. A., Bradley T. R. Bone marrow colony stimulating activity in human sera. Results of two independent surveys in Buffalo and Melbourne. Br J Haematol. 1968 Aug;15(2):147–159. doi: 10.1111/j.1365-2141.1968.tb01524.x. [DOI] [PubMed] [Google Scholar]
  7. Hulliger L., Blazkovec A. A. A simple and efficient method of separating peripheral-blood leucocytes for in-vitro studies. Lancet. 1967 Jun 17;1(7503):1304–1305. doi: 10.1016/s0140-6736(67)91596-6. [DOI] [PubMed] [Google Scholar]
  8. McNeill T. A. Antigenic stimulation of bone marrow colony forming cells. 3. Effect in vivo. Immunology. 1970 Jan;18(1):61–72. [PMC free article] [PubMed] [Google Scholar]
  9. McNeill T. A., Fleming W. A. The relationship between serum interferon and an inhibitor of mouse haemopoietic colonies in vitro. Immunology. 1971 Nov;21(5):761–766. [PMC free article] [PubMed] [Google Scholar]
  10. McNeill T. A., Killen M. Role of hemopoietic colony-forming cell responses in the pathogenesis of ectromelia. Infect Immun. 1971 Oct;4(4):331–336. doi: 10.1128/iai.4.4.331-336.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McNeill T. A., Killen M. The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vivo. Immunology. 1971 Nov;21(5):751–759. [PMC free article] [PubMed] [Google Scholar]
  12. McNeill T. A. The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vitro. Immunology. 1971 Nov;21(5):741–750. [PMC free article] [PubMed] [Google Scholar]
  13. Metcalf D. Antigen-induced proliferation in vitro of bone marrow precursors of granulocytes and macrophages. Immunology. 1971 May;20(5):727–738. [PMC free article] [PubMed] [Google Scholar]
  14. Metcalf D., Foster R. Bone marrow colony-stimulating activity of serum from mice with viral-induced leukemia. J Natl Cancer Inst. 1967 Dec;39(6):1235–1245. [PubMed] [Google Scholar]
  15. Metcalf D. Studies on colony formation in vitro by mouse bone marrow cells. II. Action of colony stimulating factor. J Cell Physiol. 1970 Aug;76(1):89–99. doi: 10.1002/jcp.1040760113. [DOI] [PubMed] [Google Scholar]
  16. Stanley E. R., Metcalf D. Partial purification and some properties of the factor in normal and leukaemic human urine stimulating mouse bone marrow colony growth in vitro. Aust J Exp Biol Med Sci. 1969 Aug;47(4):467–483. doi: 10.1038/icb.1969.51. [DOI] [PubMed] [Google Scholar]
  17. de Maeyer E., de Maeyer-Guignard J. Gene with quantitative effect on circulating interferon induced by Newcastle disease virus. J Virol. 1969 May;3(5):506–512. doi: 10.1128/jvi.3.5.506-512.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES