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. 1973 Jan;24(1):135–145.

Studies on the terminal stages of complement lysis

P J Lachmann, D E Bowyer, Prudence Nicol, R M C Dawson, E A Munn
PMCID: PMC1422877  PMID: 4346598

Abstract

Experiments are described using the reactive lysis system on phospholipid dispersions to study the terminal phases of complement lysis. It has been found that, both on lecithin and on sphingomyelin-cholesterol liposomes, marker release and characteristic EM lesions can be found upon the sequential activity of C567 and C8 and C9 and that for both these parameters of lysis the action of C8 and C9 as well as of C567, are required.

Lysis of liposomes is accompanied by the appearance of traces of the products of phospholipase activity in the supernate but it is believed that these represent the activity of contaminating enzymes and are the consequence and not the cause of lysis. However the possibility that lysis could be due to lipolytic activity cannot be totally excluded because of the negligible hydrolysis theoretically needed to form lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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