Abstract
Tritiated thymidine autoradiographs prepared from sections of guinea-pig thymus were compared with sections from animals treated with the mitotic arresting drug Colcemid. Autoradiography demonstrated the existence of two synthesizing zones, the previously described subcapsular cortex and a new zone of activity, the corticomedullary junction. The existence of these zones was confirmed quantitatively in the Colcemid-treated animals.
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- Blau J. N. The dynamic behaviour of Hassall's corpuscles and the transport of particulate matter in the thymus of the guinea-pig. Immunology. 1967 Sep;13(3):281–292. [PMC free article] [PubMed] [Google Scholar]
- Borum K. Pattern of cell production and cell migration in mouse thymus studied by autoradiography. Scand J Haematol. 1968;5(5):339–352. doi: 10.1111/j.1600-0609.1968.tb01758.x. [DOI] [PubMed] [Google Scholar]
- Clark S. L., Jr Incorporation of sulfate by the mouse thymus: its relation to secretion by medullary epithelial cells and to thymic lymphopoiesis. J Exp Med. 1968 Nov 1;128(5):927–957. doi: 10.1084/jem.128.5.927. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ernström U., Hedbäck A. L. Mitotic studies in thyroxin-stimulated thymo-lymphatic tissue. An investigation in guinea-pigs with the colchicine technique. Acta Pathol Microbiol Scand. 1965;65(2):215–220. doi: 10.1111/apm.1965.65.2.215. [DOI] [PubMed] [Google Scholar]
- HINRICHSEN K. AUTORADIOGRAPHISCHE UNTERSUCHUNGEN UEBER AUFNAHME UND VERTEILUNG VON TRITIUM-THYMIDIN IM THYMUS DER MAUS. Verh Anat Ges. 1964;59:122–130. [PubMed] [Google Scholar]
- Hinrichsen K. Zellteilungen und Zellwanderungen im Thymus der erwachsenen Maus. Z Zellforsch Mikrosk Anat. 1965 Oct 28;68(3):427–444. [PubMed] [Google Scholar]
- Morris W. T. In vivo studies on the optimum time for the action of colchicine on mouse lymphoid tissue. Exp Cell Res. 1967 Oct;48(1):209–212. doi: 10.1016/0014-4827(67)90303-5. [DOI] [PubMed] [Google Scholar]
- Nagaya H., Sieker H. O. Effects of antithymus serum on thymic lymphopoiesis: a radioautographic study. J Immunol. 1969 Oct;103(4):778–786. [PubMed] [Google Scholar]
- Olson I. A., Hunt A. C. Allograft rejection and thymic activity in the pig. J Anat. 1969 May;104(Pt 3):583–584. [PubMed] [Google Scholar]
- SAINTE-MARIE G., LEBLOND C. P. Tentative pattern for renewal of lymphocytes in cortex of the rat thymus. Proc Soc Exp Biol Med. 1958 Feb;97(2):263–270. doi: 10.3181/00379727-97-23710. [DOI] [PubMed] [Google Scholar]
- Sainte-Marie G., Messier B. Labelling of the rat thymus by intramediastinal injection of tritiated thymidine. Rev Can Biol. 1969 Sep;28(3):205–208. [PubMed] [Google Scholar]
- Sainte-Marie G., Messier B. Thymus and node labelling by intramediastinal injection of tritiated tracers and its bearing on present concepts of lymphocyte cytokinetics. Scand J Haematol. 1970;7(3):163–176. doi: 10.1111/j.1600-0609.1970.tb01884.x. [DOI] [PubMed] [Google Scholar]
- von Gaudecker B. Elektronenmikroskopische Autoradiographie mit H3-Thymidin an der Thymusrinde der Maus. Z Zellforsch Mikrosk Anat. 1966;72(3):281–294. [PubMed] [Google Scholar]

