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. 1973 Apr;24(4):607–616.

Lack of correlation between the effects of cortisone on mouse spleen plaque-forming cells and circulating anti-sheep red blood cell haemolysins

A Ferreira, C Moreno, G Hoecker
PMCID: PMC1422902  PMID: 4574796

Abstract

The effect of 5.5 mg of cortisone acetate given to adult mice 1 day prior to the injection of 4 × 108 sheep erythrocytes was studied. This drug is able to suppress more than 95 per cent of splenic plaque-forming cells (PFC) compared with immunized animals not treated with cortisone. However, the anti-sheep red cell haemolytic titre in the blood was not affected. Several hypotheses to explain this paradox were tested experimentally.

Plaque-forming cells in the bone-marrow of cortisone-treated mice, instead of being suppressed, increased to more than ten times their number compared with the controlled animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett M. Hemopoietic environment necessary for an early stage in differentiation of antibody-forming cells: effect of cortisol. J Cell Physiol. 1970 Oct;76(2):197–205. doi: 10.1002/jcp.1040760210. [DOI] [PubMed] [Google Scholar]
  2. DOUGHERTY T. F. Effect of hormones on lympatic tissue. Physiol Rev. 1952 Oct;32(4):379–401. doi: 10.1152/physrev.1952.32.4.379. [DOI] [PubMed] [Google Scholar]
  3. Dietrich F. M. The immune response to heterologous red cells in mice. Immunology. 1966 Apr;10(4):365–376. [PMC free article] [PubMed] [Google Scholar]
  4. Eisenberg R. A., Weissman I. L. Antibody inhibition of the immune response: experimental analysis of the site of action in vivo. J Immunol. 1971 Jan;106(1):143–149. [PubMed] [Google Scholar]
  5. Elliott E. V., Sinclair N. R. Effect of cortisone acetate on 19S and 7S haemolysin antibody. A time course study. Immunology. 1968 Nov;15(5):643–652. [PMC free article] [PubMed] [Google Scholar]
  6. INGRAHAM J. S., BUSSARD A. APPLICATION OF A LOCALIZED HEMOLYSIN REACTION FOR SPECIFIC DETECTION OF INDIVIDUAL ANTIBODY-FORMING CELLS. J Exp Med. 1964 Apr 1;119:667–684. doi: 10.1084/jem.119.4.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Levine M. A., Claman H. N. Bone marrow and spleen: dissociation of immunologic properties by cortisone. Science. 1970 Mar 13;167(3924):1515–1517. doi: 10.1126/science.167.3924.1515. [DOI] [PubMed] [Google Scholar]
  8. MOLLER G., WIGZELL H. ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE. J Exp Med. 1965 Jun 1;121:969–989. doi: 10.1084/jem.121.6.969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Merchant B., Petersen B. Comparative sensitivities of the hemolytic plaque-in-agar and microchamber assays for detection of rabbit immune cells. J Immunol. 1968 Nov;101(5):860–867. [PubMed] [Google Scholar]
  10. Möller G. Regulation of cellular antibody synthesis. Selective suppression by antibody of the immune response induced by a high antigen dose. Immunology. 1969 Aug;17(2):227–235. [PMC free article] [PubMed] [Google Scholar]
  11. Pantelouris E. M., Flisch P. A. Estimation of PFC and serum haemolysin response to SRBC in 'nude' mice. Immunology. 1972 Jan;22(1):159–164. [PMC free article] [PubMed] [Google Scholar]
  12. Petrányi G., Jr, Benczúr M., Alföldy P. The effect of single large dose hydrocortisone treatment on IgM and IgG antibody production, morphological distribution of antibody producing cells and immunological memory. Immunology. 1971 Jul;21(1):151–158. [PMC free article] [PubMed] [Google Scholar]
  13. Ryder R. J., Schwartz R. S. Immunosuppression by antibody: localization of site of action. J Immunol. 1969 Nov;103(5):970–978. [PubMed] [Google Scholar]
  14. Sinclair N. R., Chan P. L. Relationship between antibody-mediated immunosuppression and tolerance induction. Nature. 1971 Nov 12;234(5324):104–105. doi: 10.1038/234104a0. [DOI] [PubMed] [Google Scholar]
  15. Sterzl J., Ríha I. Detection of cells producing 7S antibodies by the plaque technique. Nature. 1965 Nov 27;208(5013):858–859. doi: 10.1038/208858a0. [DOI] [PubMed] [Google Scholar]
  16. Stevens W., Bedke C., Dougherty T. F. Effects of cortisol acetate on various aspects of cellular metabolism in mouse lymphatic tissue. J Reticuloendothel Soc. 1967 Jul;4(4):254–283. [PubMed] [Google Scholar]
  17. UHR J. W., FINKELSTEIN M. S. Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunological memory to bacteriophage phi-X 174. J Exp Med. 1963 Mar 1;117:457–477. doi: 10.1084/jem.117.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. WASSERMAN E., LEVINE L. Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition. J Immunol. 1961 Sep;87:290–295. [PubMed] [Google Scholar]
  19. Weyer J., Bourgarit J. J., Bussard A. E. Kinetics of antibody production by single cells. I. Automatic recording of plaque production in the local haemolysis system. Immunology. 1972 Mar;22(3):347–359. [PMC free article] [PubMed] [Google Scholar]
  20. Wigzell H., Möller G., Andersson B. Studies at the cellular level of the 19S immune response. Acta Pathol Microbiol Scand. 1966;66(4):530–540. doi: 10.1111/apm.1966.66.4.530. [DOI] [PubMed] [Google Scholar]
  21. Wlodarski K., Zaleski M. Effect of cortisone acetate on plaque-forming cell formation in mice. Folia Biol (Praha) 1970;16(6):427–430. [PubMed] [Google Scholar]

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