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. 1973 Mar;24(3):455–465.

The effect of antilymphocytic antibody on the humoral immune response in different strains of mice

II. The response to sheep erythrocytes

A Ghaffar, K James
PMCID: PMC1422968  PMID: 4574575

Abstract

The effect of an horse anti-mouse thymocyte globulin (ALG) preparation on the primary and secondary immune responses to sheep erythrocytes (RBC) was studied in 2–3-month-old male A/HeJ, C57B1, BALB/c, DBA/1, CBA and C3H mice. A wide variation in the primary and secondary responses of the individual strains was noticed but in all cases these were significantly suppressed by ALG pretreatment. The capacity of the ALG to suppress the primary immune response was not overcome by increasing the antigen dose from 3 × 107 to 3 × 109 sheep RBC.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson H. R., Dresser D. W., Iverson G. M., Lance E. M., Wortis H. H., Zebra J. The effects of ALG on the murine immune response to sheep erythrocytes. Immunology. 1972 Feb;22(2):277–289. [PMC free article] [PubMed] [Google Scholar]
  2. Argyris B. F., Plotkin D. H. Effects of antimacrophage, antithymocyte, antilymphocyte and antispleen serum on the immune response in mice. Clin Exp Immunol. 1970 Oct;7(4):551–564. [PMC free article] [PubMed] [Google Scholar]
  3. Baker P. J., Barth R. F., Stashak P. W., Amsbaugh D. F. Enhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum. J Immunol. 1970 May;104(5):1313–1315. [PubMed] [Google Scholar]
  4. Barth R. F., Southworth J. Studies on heterologous antilymphocyte and antithymocyte sera. II. Effects on cellular antibody production during the early primary and secondary immune response of mice to sheep erythrocytes. J Immunol. 1968 Dec;101(6):1283–1290. [PubMed] [Google Scholar]
  5. Baum J., Liebermann G., Frenkel E. P. The effect of immunologically induced lymphopenia on antibody formation. J Immunol. 1969 Jan;102(1):187–193. [PubMed] [Google Scholar]
  6. Braley H. C., Freeman M. J. Strain differences in the antibody plaque-forming cell responses of inbred mice to pneumococcal polysaccharide. Cell Immunol. 1971 Feb;2(1):73–81. doi: 10.1016/0008-8749(71)90026-8. [DOI] [PubMed] [Google Scholar]
  7. Cerottini J. C., Lambert P. H., Dixon F. J. Comparison of the immune responsiveness of NZB and NZB X NZW F1 hybrid mice with that of other strains of mice. J Exp Med. 1969 Nov 1;130(5):1093–1105. doi: 10.1084/jem.130.5.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FRIEDMAN H. DISTRIBUTION OF ANTIBODY PLAQUE FORMING CELLS IN VARIOUS TISSUES OF SEVERAL STRAINS OF MICE INJECTED WITH SHEEP ERYTHROCYTES. Proc Soc Exp Biol Med. 1964 Nov;117:526–530. doi: 10.3181/00379727-117-29628. [DOI] [PubMed] [Google Scholar]
  9. James K., Milne I. The effect of antilymphocytic antibody on the primary immune response of mice to sheep erythrocytes, bovine serum albumin, and type 3 pneumococcus polysaccharide. Transplantation. 1971 Aug;12(2):109–113. doi: 10.1097/00007890-197108000-00002. [DOI] [PubMed] [Google Scholar]
  10. Kerbel R. S., Eidinger D. Variable effects of anti-lymphocyte serum on humoral antibody formation: role of thymus dependency of antigen. J Immunol. 1971 Apr;106(4):917–926. [PubMed] [Google Scholar]
  11. Lance E. M. The effect of heterologous antilymphocyte serum (ALS) on the humoral antibody response to Salmonella typhi "H" antigen and bovine serum albumin. J Immunol. 1970 Jul;105(1):108–117. [PubMed] [Google Scholar]
  12. McDevitt H. O., Chinitz A. Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type. Science. 1969 Mar 14;163(3872):1207–1208. doi: 10.1126/science.163.3872.1207. [DOI] [PubMed] [Google Scholar]
  13. Playfair J. H. Strain differences in the immune response of mice. I. The neonatal response to sheep red cells. Immunology. 1968 Jul;15(1):35–50. [PMC free article] [PubMed] [Google Scholar]
  14. Torrigiani G. Quantitative estimation of antibodies in the immunoglobulin classes of the mouse. I. Effect of adjuvants on the antibody response to human serum albumin and keyhole limpet haemocyanin. Clin Exp Immunol. 1972 May;11(1):125–135. [PMC free article] [PubMed] [Google Scholar]
  15. Vaz N. M., Vaz E. M., Levine B. B. Relationship between histocompatibility (H-2) genotype and immune responsiveness to low doses of ovalbumin in the mouse. J Immunol. 1970 Jun;104(6):1572–1574. [PubMed] [Google Scholar]
  16. Wortis H. H., Dresser D. W., Anderson H. R. Antibody production studied by means of the localized haemolysis in gel (LHG) assay. 3. Mouse cells producing five different classes of antibody. Immunology. 1969 Jul;17(1):93–110. [PMC free article] [PubMed] [Google Scholar]

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