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. 1973 Mar;24(3):579–588.

Cross-reactions between erythrocytes at the T-cell level

J H L Playfair, S Marshall-Clarke
PMCID: PMC1422976  PMID: 4540957

Abstract

The response of bone marrow (B) cells to sheep red blood cells (SRBC) was measured in the presence of thymus-derived (T) cells that had been stimulated by SRBC or RBC from other species. It was found that other RBC, notably pig and rabbit, were much more effective in stimulating T cells for a cooperative response to SRBC than would have been predicted from the very slight cross-reaction between these RBC and SRBC at the antibody level. It is concluded that recognition of antigens at the T-cell level is different, and in this case less specific, than at the level of the B cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
  2. Chiller J. M., Habicht G. S., Weigle W. O. Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science. 1971 Feb 26;171(3973):813–815. doi: 10.1126/science.171.3973.813. [DOI] [PubMed] [Google Scholar]
  3. Ekpaha-Mensah A., Kennedy J. C. New indicator of histocompatibility differences in vitro. Nat New Biol. 1971 Oct 6;233(40):174–176. doi: 10.1038/newbio233174a0. [DOI] [PubMed] [Google Scholar]
  4. Falkoff R., Kettman J. Differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice. J Immunol. 1972 Jan;108(1):54–58. [PubMed] [Google Scholar]
  5. Hartmann K. U. Induction of a hemolysin response in vitro. Interaction of cells of bone marrow origin and thymic origin. J Exp Med. 1970 Dec 1;132(6):1267–1278. doi: 10.1084/jem.132.6.1267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hoffmann M., Kappler J. W. The antigen specificity of thymus-derived helper cells. J Immunol. 1972 Jan;108(1):261–263. [PubMed] [Google Scholar]
  7. Jones G. Lymphocyte activation. I. Expression of theta, H-2 and immunoglobulin determinants on lymphocytes stimulated by phytohaemagglutinin, pokeweed mitogen, concanavalin A or histocompatibility antigen. Clin Exp Immunol. 1972 Nov;12(3):391–402. [PMC free article] [PubMed] [Google Scholar]
  8. Kettman J., Dutton R. W. Radioresistance of the enhancing effect of cells from carrier-immunized mice in an in vitro primary immune response. Proc Natl Acad Sci U S A. 1971 Apr;68(4):699–703. doi: 10.1073/pnas.68.4.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lawrence W., Jr, Simonsen M. The property of "strength" of histocompatibility antigens, and their ability to produce antigenic competition. Transplantation. 1967 Sep 5;5(5):1304–1322. doi: 10.1097/00007890-196709000-00009. [DOI] [PubMed] [Google Scholar]
  10. Miller J. F., Mitchell G. F. Thymus and antigen-reactive cells. Transplant Rev. 1969;1:3–42. doi: 10.1111/j.1600-065x.1969.tb00135.x. [DOI] [PubMed] [Google Scholar]
  11. Mitchell G. F., Grumet F. C., McDevitt H. O. Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys. J Exp Med. 1972 Jan;135(1):126–135. doi: 10.1084/jem.135.1.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Paul W. E., Stupp Y., Siskind G. W., Benacerraf B. Structural control of immunogenicity. IV. Relative specificity of elicitation of cellular immune responses and of ligand binding to anti-hapten antibody after immunization with mono-epsilon-DNP-nona-L-lysine. Immunology. 1971 Oct;21(4):605–616. [PMC free article] [PubMed] [Google Scholar]
  13. Playfair J. H. Cell cooperation in the immune response. Clin Exp Immunol. 1971 Jun;8(6):839–856. [PMC free article] [PubMed] [Google Scholar]
  14. Playfair J. H., Purves E. C. Antibody formation by bone marrow cells in irradiated mice. I. Thymus-dependent and thymus-independent responses to sheep erythrocytes. Immunology. 1971 Jul;21(1):113–121. [PMC free article] [PubMed] [Google Scholar]
  15. Playfair J. H. Response of mouse T and B lymphocytes to sheep erythrocytes. Nat New Biol. 1972 Jan 26;235(56):115–118. doi: 10.1038/newbio235115a0. [DOI] [PubMed] [Google Scholar]
  16. Playfair J. H. Strain differences in the immune response of mice. II. Responses by neonatal cells in irradiated adult hosts. Immunology. 1968 Dec;15(6):815–826. [PMC free article] [PubMed] [Google Scholar]
  17. Tyan M. L. Genetically determined immune responses: in vitro studies. J Immunol. 1972 Jan;108(1):65–72. [PubMed] [Google Scholar]

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