Abstract
After immunization with group B or group C streptococcal vaccines, antiglobulins and cryoglobulins were found in the sera of rabbits producing homogeneous antibodies. The cryoglobulins contained antiglobulin activity and homogeneous streptococcal antibodies. The antiglobulins reacted with both rabbit and human IgG. Precipitating antibody activity to rabbit IgG lacking sialic acid was identified in one cryoglobulin.
A rabbit that produced two homogeneous antibodies to group B streptococci produced a third homogeneous immunoglobulin without anti-streptococcal antibody activity after deliberate immunization with rabbit IgG. The appearance of the new homogeneous immunoglobulin coincided with re-stimulation of antiglobulin formation. The possibility is discussed that antiglobulin antibodies may be responsible for the clonal proliferation of plasma cells that leads to homogeneous immunoglobulin production.
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- Abdou N. I., Abdou N. L. Anit-immunoglobulins in multiple myeloma. Clin Exp Immunol. 1972 May;11(1):57–65. [PMC free article] [PubMed] [Google Scholar]
- Bokisch V. A., Bernstein D., Krause R. M. Occurrence of 19S and 7S anti-IgGs during hyperimmunization of rabbits with streptococci. J Exp Med. 1972 Oct 1;136(4):799–815. doi: 10.1084/jem.136.4.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brenneman L., Singer S. J. On homogeneous antigens and antibodies. 3. The preparation and properties of the univalent hapten-protein conjugate papain-S-DNPL. Ann N Y Acad Sci. 1970 Feb 13;169(1):72–92. doi: 10.1111/j.1749-6632.1970.tb55972.x. [DOI] [PubMed] [Google Scholar]
- Goldberg L. S., Fudenberg H. H. Antiglobulins and human disease. Vox Sang. 1971 Jan;20(1):1–6. doi: 10.1111/j.1423-0410.1971.tb01794.x. [DOI] [PubMed] [Google Scholar]
- Haber E. Immunochemistry. Annu Rev Biochem. 1968;37:497–520. doi: 10.1146/annurev.bi.37.070168.002433. [DOI] [PubMed] [Google Scholar]
- Herd Z. L., Spragg J. The occurrence of homogeneous antibodies and antigenic selection of kappa light chains to streptococcal carbohydrates in Monash rabbits. Aust J Exp Biol Med Sci. 1972 Apr;50(2):225–243. doi: 10.1038/icb.1972.19. [DOI] [PubMed] [Google Scholar]
- Kimball J. W., Pappenheimer A. M., Jr, Jaton J. C. The response in rabbits to prolonged immunization with type 3 pneumococci. J Immunol. 1971 May;106(5):1177–1184. [PubMed] [Google Scholar]
- Krause R. M. The search for antibodies with molecular uniformity. Adv Immunol. 1970;12:1–56. doi: 10.1016/s0065-2776(08)60167-4. [DOI] [PubMed] [Google Scholar]
- McIntosh R. M., Kaufman D. B., McIntosh J. R., Griswold W. Glomerular lesions produced by autologous serum and autologous IgG modified by treatment with a culture of a -haemolytic streptooccus. J Med Microbiol. 1972 Feb;5(1):1–7. doi: 10.1099/00222615-5-1-1. [DOI] [PubMed] [Google Scholar]
- WILLIAMS R. C., Jr, KUNKEL H. G. Antibodies to rabbit gamma-globulin after immunizing with various preparations of autologous gamma-globulin. Proc Soc Exp Biol Med. 1963 Mar;112:554–561. doi: 10.3181/00379727-112-28104. [DOI] [PubMed] [Google Scholar]
- Williams R. C., Jr, Mellbye O. J., Kronvall G. Anti-gamma globulins and chronic infection: comparative studies of the immune response to various bacteria and gamma globulin preparations. Infect Immun. 1972 Sep;6(3):316–323. doi: 10.1128/iai.6.3.316-323.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinneman H. H., Levi D., Seal U. S. On the nature of cryoglobulins. J Immunol. 1968 Mar;100(3):594–603. [PubMed] [Google Scholar]