Abstract
The transformation of cultured lymphocytes in response to stimulation by phytohaemagglutinin (PHA) and purified protein derivative (PPD) in nineteen patients with chronic renal failure and four normal controls was studied. This was significantly lower in the patients than in the controls in response to both stimulants. Among the patients those with blood urea level higher than 200 mg/ml showed a transformation rate significantly higher than those with lower levels of blood urea in response to PHA. Mean values of transformation rate were lower in patients of the older age group (>50 years) and in the more chronic cases (>5 years) but the differences were not statistically significant.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Carstairs K. C., Breckenridge A., Dollery C. T., Worlledge S. M. Incidence of a positive direct coombs test in patients on alpha-methyldopa. Lancet. 1966 Jul 16;2(7455):133–135. doi: 10.1016/s0140-6736(66)92422-6. [DOI] [PubMed] [Google Scholar]
- Coulson A. S., Chalmers D. G. Response of human blood lymphocytes to tuberculin PPD in tissue culture. Immunology. 1967 Apr;12(4):417–429. [PMC free article] [PubMed] [Google Scholar]
- DAMMIN G. J., COUCH N. P., MURRAY J. E. Prolonged survival of skin homografts in uremic patients. Ann N Y Acad Sci. 1957 Mar 22;64(5):967–976. doi: 10.1111/j.1749-6632.1957.tb52488.x. [DOI] [PubMed] [Google Scholar]
- HUME D. M., MERRILL J. P., MILLER B. F., THORN G. W. Experiences with renal homotransplantation in the human: report of nine cases. J Clin Invest. 1955 Feb;34(2):327–382. doi: 10.1172/JCI103085. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RIIS P., STOUGAARD J. The peripheral blood leukocytes in chronic renal insufficiency. Dan Med Bull. 1959 May;6(3):85–90. [PubMed] [Google Scholar]
- ROBBINS J. H. TISSUE CULTURE STUDIES OF THE HUMAN LYMPHOCYTE. Science. 1964 Dec 25;146(3652):1648–1654. doi: 10.1126/science.146.3652.1648. [DOI] [PubMed] [Google Scholar]
- Robinson M. R., Nakhla L. S., Whitaker R. H. Lymphocyte transformation inb carcinoma of the prostate. Br J Urol. 1971 Aug;43(4):480–486. doi: 10.1111/j.1464-410x.1971.tb12072.x. [DOI] [PubMed] [Google Scholar]
- Silk M. R. The effect of uremic plasma on lymphocyte transformation. Invest Urol. 1967 Sep;5(2):195–199. [PubMed] [Google Scholar]
- Wolstencroft R. A., Dumonde D. C. In vitro studies of cell-mediated immunity. I. Induction of lymphocyte transformation by a soluble "mitogenic" factor derived from interaction of sensitized guinea-pig lymphoid cells with specific antigen. Immunology. 1970 Apr;18(4):599–610. [PMC free article] [PubMed] [Google Scholar]
- Worlledge S. M., Carstairs K. C., Dacie J. V. Autoimmune haemolytic anaemia associated with alpha-methyldopa therapy. Lancet. 1966 Jul 16;2(7455):135–139. doi: 10.1016/s0140-6736(66)92423-8. [DOI] [PubMed] [Google Scholar]