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. 1974 Feb;26(2):375–382.

A homeostatic mechanism for the removal of antigen from the portal circulation*

H C Thomas, F Vaez-Zadeh
PMCID: PMC1423088  PMID: 4850212

Abstract

Immunogenic molecules are being absorbed continually from the alimentary tract and a substantial proportion of normal people have detectable levels of circulating antibody against soluble food proteins and intestinal bacteria.

In our view antibodies to soluble proteins form part of a physiological mechanism for preventing these proteins from entering the systemic circulation. In the absence of antibody the liver failed to remove significant quantities of soluble protein antigen from the portal circulation, but in the animal with sufficient circulating antibody to combine with antigen in optimal proportions, the liver retained 80 per cent of the injected protein. The liver became progressively less efficient for the removal of injected complexes which had been prepared in vitro and contained increasing amounts of antigen in excess of optimal proportions.

The consequences of antigen excess, as they relate to inflammatory bowel disease, are discussed. The theoretical consequences of antibody excess are also discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpers D. H., Isselbacher K. J. Protein synthesis by rat intestinal mucosa. The role of ribonuclease. J Biol Chem. 1967 Dec 10;242(23):5617–5622. [PubMed] [Google Scholar]
  2. Bernstein I. D., Ovary Z. Absorption of antigens from the gastrointestinal tract. Int Arch Allergy Appl Immunol. 1968;33(6):521–527. doi: 10.1159/000230068. [DOI] [PubMed] [Google Scholar]
  3. Bjorneboe M., Prytz H., Orskov F. Antibodies to intestinal microbes in serum of patients with cirrhosis of the liver. Lancet. 1972 Jan 8;1(7741):58–60. doi: 10.1016/s0140-6736(72)90060-8. [DOI] [PubMed] [Google Scholar]
  4. Cornell R., Walker W. A., Isselbacher K. J. Small intestinal absorption of horseradish peroxidase. A cytochemical study. Lab Invest. 1971 Jul;25(1):42–48. [PubMed] [Google Scholar]
  5. Doe W. F., Booth C. C., Brown D. L. Evidence for complement-binding immune complexes in adult coeliac disease, Crohn's disease, and ulcerative colitis. Lancet. 1973 Feb 24;1(7800):402–403. doi: 10.1016/s0140-6736(73)90254-7. [DOI] [PubMed] [Google Scholar]
  6. FARR R. S. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J Infect Dis. 1958 Nov-Dec;103(3):239–262. doi: 10.1093/infdis/103.3.239. [DOI] [PubMed] [Google Scholar]
  7. Jewell D. P., Truelove S. C. Circulating antibodies to cow's milk proteins in ulcerative colitis. Gut. 1972 Oct;13(10):796–801. [PMC free article] [PubMed] [Google Scholar]
  8. McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
  9. Mowbray J. F., Hoffbrand A. V., Holborow E. J., Seah P. P., Fry L. Circulating immune complexes in dermatitis herpetiformis. Lancet. 1973 Feb 24;1(7800):400–402. doi: 10.1016/s0140-6736(73)90253-5. [DOI] [PubMed] [Google Scholar]
  10. ROWLEY D. A. The effect of splenectomy on the formation of circulating antibody in the adult male albino rat. J Immunol. 1950 Apr;64(4):289–295. [PubMed] [Google Scholar]
  11. ROWLEY D. A. The formation of circulating antibody in the splenectomized human being following intravenous injection of heterologous erythrocytes. J Immunol. 1950 Nov;65(5):515–521. [PubMed] [Google Scholar]
  12. SELL S., FAHEY J. L. RELATIONSHIP BETWEEN GAMMA-GLOBULIN METABOLISM AND LOW SERUM GAMMA-GLOBULIN IN GERMFREE MICE. J Immunol. 1964 Jul;93:81–87. [PubMed] [Google Scholar]
  13. Thomas H. C., McSween R. N., White R. G. Role of the liver in controlling the immunogenicity of commensal bacteria in the gut. Lancet. 1973 Jun 9;1(7815):1288–1291. doi: 10.1016/s0140-6736(73)91300-7. [DOI] [PubMed] [Google Scholar]
  14. Triger D. R., Alp M. H., Wright R. Bacterial and dietary antibodies in liver disease. Lancet. 1972 Jan 8;1(7741):60–63. doi: 10.1016/s0140-6736(72)90061-x. [DOI] [PubMed] [Google Scholar]
  15. Warshaw A. L., Walker W. A., Cornell R., Isselbacher K. J. Small intestinal permeability to macromolecules. Transmission of horseradish peroxidase into mesenteric lymph and portal blood. Lab Invest. 1971 Dec;25(6):675–684. [PubMed] [Google Scholar]

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