Abstract
Regeneration of follicular structures in the rabbit spleen after a single dose of 450 rads whole body X-irradiation was shown to be dependent upon the presence of the appendix.
Results obtained were in favour of a stream of cells—probably derived from appendix germinal centres—to follicular structures in the spleen, in particular to the lymphocyte corona and marginal zone but excluding germinal centres.
Recovery of the antibody forming potential following X-irradiation was equally shown to be dependent upon the presence of the appendix.
It was concluded that following 450 rads whole body X-irradiation the appendix contributes to the recovery of the antibody forming capacity of the spleen by the production of antibody-forming cell precursors; these latter cells are presumably identical with the follicle replenishing class of lymphocytes derived from appendix germinal centres.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COOPER M. D., PETERSON R. D., GOOD R. A. DELINEATION OF THE THYMIC AND BURSAL LYMPHOID SYSTEMS IN THE CHICKEN. Nature. 1965 Jan 9;205:143–146. doi: 10.1038/205143a0. [DOI] [PubMed] [Google Scholar]
- Cooper M. D., Perey D. Y., McKneally M. F., Gabrielsen A. E., Sutherland D. E., Good R. A. A mammalian equivalent of the avian bursa of Fabricius. Lancet. 1966 Jun 25;1(7452):1388–1391. doi: 10.1016/s0140-6736(66)90300-x. [DOI] [PubMed] [Google Scholar]
- DRAPER L. R., SUSSDORF D. H. The primary hemolysin response in rabbits following shielding from x rays of x irradiation of the spleen, appendix, liver or hind legs. J Infect Dis. 1956 Sep-Oct;99(2):129–142. doi: 10.1093/infdis/99.2.129. [DOI] [PubMed] [Google Scholar]
- NYGAARD O. F., POTTER R. L. Effect of x-radiation on DNA metabolism in various tissues of the rat. I. Incorporation of C14-thymidine into DNA during the first 24 hours postirradiation. Radiat Res. 1959 Apr;10(4):462–476. [PubMed] [Google Scholar]
- Nieuwenhuis P., Keuning F. J. Germinal centres and the origin of the B-cell system. II. Germinal centres in the rabbit spleen and popliteal lymph nodes. Immunology. 1974 Mar;26(3):509–519. [PMC free article] [PubMed] [Google Scholar]
- PELC S. R. The stripping-film technique of autoradiography. Int J Appl Radiat Isot. 1956 Nov;1(3):172–177. doi: 10.1016/0020-708x(56)90003-5. [DOI] [PubMed] [Google Scholar]
- SUSSDORF D. H. Repopulation of the spleen of x-irradiated rabbits by tritium-labeled lymphoid cells of the shielded appendix. J Infect Dis. 1960 Jul-Aug;107:108–114. doi: 10.1093/infdis/107.1.108. [DOI] [PubMed] [Google Scholar]