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. 1974 May;26(5):943–955.

Studies on antigenic competition

III. Effect of antigenic competition on antibody affinity*

Young Tai Kim, Nancy Merrifield, T Zarchy, N I Brody, G W Siskind
PMCID: PMC1423252  PMID: 4854459

Abstract

The effect of antigenic competition on antibody affinity was studied using a haptenic system in guinea-pigs. A moderate depression in the amount of antibody formed, as a result of antigenic competition, had relatively little effect on affinity. Increasing the dose of the competing antigen resulted in a greater degree of competition. Under these conditions a large amount of low affinity antibody was produced by the animals while essentially no high affinity antibody was detectable. Thus, marked competition appeared to result in a failure to select for high affinity antibody synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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