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. 1964 Mar;7(2):118–126.

Interactions of macrophages and erythrocytes

R B Vaughan, S V Boyden
PMCID: PMC1423306  PMID: 14135428

Abstract

An in vitro technique is described which demonstrates a difference in the interaction of fresh and stored, effete, red cells with autologous macrophages. The stored erythrocytes adhere to macrophages whereas fresh erythrocytes do not.

The effects on this difference of the medium in which the red cells are stored, and of the storage temperature, are described. Results are presented which indicate that serum opsonic factors are not necessary for the adherence of the stored red cells to macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ESSNER E. An electron microscopic study of erythrophagocytosis. J Biophys Biochem Cytol. 1960 Apr;7:329–334. doi: 10.1083/jcb.7.2.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. HOWARD J. G., WARDLAW A. C. The opsonic effect of normal serum on the uptake of bacteria by the reticulo-endothelial system; perfusion studies with isolated rat liver. Immunology. 1958 Oct;1(4):338–352. [PMC free article] [PubMed] [Google Scholar]
  3. HUGHES JONES N. C. The use of 51Cr and 59Fe as red cell labels to determine the fate of normal erythrocytes in the rabbit. Clin Sci. 1961 Jun;20:315–321. [PubMed] [Google Scholar]
  4. JANDL J. H., TOMLINSON A. S. The destruction of red cells by antibodies in man. II. Pyrogenic, leukocytic and dermal responses to immune hemolysis. J Clin Invest. 1958 Aug;37(8):1202–1228. doi: 10.1172/JCI103710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. JENKIN C. R., ROWLEY D. The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system. J Exp Med. 1961 Sep 1;114:363–374. doi: 10.1084/jem.114.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MACKANESS G. B. The phagocytosis and inactivation of staphylococci by macrophages of normal rabbits. J Exp Med. 1960 Jul 1;112:35–53. doi: 10.1084/jem.112.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MURRAY I. M. The mechanism of blockade of the reticuloendothelial system. J Exp Med. 1963 Jan 1;117:139–147. doi: 10.1084/jem.117.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. NOYES W. D., BOTHWELL T. H., FINCH C. A. The role of the reticulo-endothelial cell in iron metabolism. Br J Haematol. 1960 Jan;6:43–55. doi: 10.1111/j.1365-2141.1960.tb06216.x. [DOI] [PubMed] [Google Scholar]
  9. Ross J. F., Finch C. A., Peacock W. C., Sammons M. E. THE IN VITRO PRESERVATION AND POST-TRANSFUSION SURVIVAL OF STORED BLOOD. J Clin Invest. 1947 Jul;26(4):687–703. doi: 10.1172/JCI101853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SMITH F. Erythrophagocytosis in human lymph-glands. J Pathol Bacteriol. 1958 Oct;76(2):383–392. doi: 10.1002/path.1700760207. [DOI] [PubMed] [Google Scholar]
  11. WHITBY J. L., ROWLEY D. The role of macrophages in the elimination of bacteria from the mouse peritoneum. Br J Exp Pathol. 1959 Aug;40:358–370. [PMC free article] [PubMed] [Google Scholar]
  12. von EHRENSTEIN, LOCKNER D. Physiological erythrocyte decomposition. Acta Haematol. 1959 Sep;22:129–139. doi: 10.1159/000205768. [DOI] [PubMed] [Google Scholar]

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