Abstract
The tolerant state of rabbits tolerant to BSA was terminated following the injection of arsanil—sulfanil—BSA and native HSA. Although the injection of soluble arsanil—sulfanil—BSA usually resulted in the loss of tolerance to BSA, it was more effective if it was incorporated into Freund's adjuvant. The incorporation of mycobacteria into the adjuvant resulted in a further increase in the level of circulating anti-BSA. On the other hand, the incorporation of HSA into complete Freund's adjuvant had little enhancing effect on the termination of BSA tolerance following injection of HSA, although there was an enhancement in the production of circulating anti-HSA. Simultaneous injection of soluble BSA with HSA or arsanil—sulfanil—BSA interfered with the termination of BSA tolerance. It was possible to terminate the tolerant state of rabbits tolerant to BGG following injection of HGG but not following injection of aggregated BGG.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHRISTIAN C. L. Studies of aggregated gamma-globulin. I. Sedimentation, electrophoretic and anticomplementary properties. J Immunol. 1960 Jan;84:112–116. [PubMed] [Google Scholar]
- CSIZMAS L. Preparation of formalinized erythrocytes. Proc Soc Exp Biol Med. 1960 Jan;103:157–160. doi: 10.3181/00379727-103-25444. [DOI] [PubMed] [Google Scholar]
- FARR R. S. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J Infect Dis. 1958 Nov-Dec;103(3):239–262. doi: 10.1093/infdis/103.3.239. [DOI] [PubMed] [Google Scholar]
- OVARY Z. Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction. Prog Allergy. 1958;5:459–508. [PubMed] [Google Scholar]
- TAKATSY G. The use of spiral loops in serological and virological micro-methods. Acta Microbiol Acad Sci Hung. 1955;3(1-2):191–202. [PubMed] [Google Scholar]
- TALMAGE D. W., MAURER P. H. I131-Labelled antigen precipitation as a measure of quantity and quality of antibody. J Infect Dis. 1953 May-Jun;92(3):288–300. doi: 10.1093/infdis/92.3.288. [DOI] [PubMed] [Google Scholar]
- WEIGLE W. O., DIXON F. J. Elimination of heterologous proteins from blood of normal, x-radiated and tolerant rabbits. Proc Soc Exp Biol Med. 1958 Jun;98(2):213–215. doi: 10.3181/00379727-98-23994. [DOI] [PubMed] [Google Scholar]
- WEIGLE W. O., DIXON F. J. The antibody response of lymph node cells transferred to tolerant recipients. J Immunol. 1959 Jun;82(6):516–519. [PubMed] [Google Scholar]
- WEIGLE W. O. Elimination of I131 labelled homologous and heterologous serum proteins from blood of various species. Proc Soc Exp Biol Med. 1957 Feb;94(2):306–309. doi: 10.3181/00379727-94-22930. [DOI] [PubMed] [Google Scholar]
- WEIGLE W. O. Immunochemical properties of the cross-reactions between anti-BSA and heterologous albumins. J Immunol. 1961 Nov;87:599–607. [PubMed] [Google Scholar]
- WEIGLE W. O. Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens. J Exp Med. 1962 Dec 1;116:913–928. doi: 10.1084/jem.116.6.913. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEIGLE W. O. The immune response of rabbits tolerant to bovine serum albumin to the injection of other heterologous serum albumins. J Exp Med. 1961 Jul 1;114:111–125. doi: 10.1084/jem.114.1.111. [DOI] [PMC free article] [PubMed] [Google Scholar]